2,6-diethyl-heptanedioic acid | 34833-00-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,6-diethyl-heptanedioic acid
• 英文别名: 2,6-Diaethyl-heptandisaeure；α,α'-Diethylpimelinsaeure；2,6-Diethylheptanedioic acid
• CAS: 34833-00-6
• 化学式: C₁₁H₂₀O₄
• 分子量: 216.277
• InChiKey: NBPMKYKTGSYOPL-UHFFFAOYSA-N

物化性质

• 沸点：
  378.4±25.0 °C(Predicted)
• 密度：
  1.080±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,6-diethyl-heptanedioic acid 在 barium dihydroxide 作用下， 生成 2,6-二乙基环己酮
  参考文献：
  名称：

  Conformational Analysis in Symmetrically Substituted Cyclohexanones. The Alkyl Ketone Effects

  摘要：

  DOI：

  10.1021/ja00871a028
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 2,6-diethyl-heptanedioic acid
  参考文献：
  名称：

  Perkin; Prentice, Journal of the Chemical Society, 1891, vol. 59, p. 834

  摘要：

  DOI：

文献信息

• [EN] NITROGEN-CONTAINING HETEROCYCLIC COMPOUND<br/>[FR] COMPOSÉ HÉTÉROCYCLIQUE CONTENANT DE L'AZOTE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2013018929A1

  公开（公告）日：2013-02-07

  The present invention provides a novel compound having a superior activity as an ERR-α modulator and useful as an agent for the prophylaxis or treatment of ERR-α associated diseases. The present invention relates to a compound represented by the formula (1) wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种新型的化合物，作为一种ERR-α调节剂具有优越的活性，并可作为预防或治疗与ERR-α相关疾病的药物。本发明涉及一种由公式(1)表示的化合物，其中每个符号如说明书中所定义，或其盐。
• [EN] ARGINASE INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS D'ARGINASE ET PROCÉDÉS D'UTILISATION
  申请人：MERCK SHARP & DOHME

  公开号：WO2019245890A1

  公开（公告）日：2019-12-26

  Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula (I) act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.

  本文描述了式（I）的化合物或其药用盐。式（I）的化合物作为精氨酸酶抑制剂，可用于预防、治疗或作为精氨酸酶相关疾病的治疗剂。
• REUSABLE PRINT MEDIUM AND METHOD OF MANUFACTURING THEREOF
  申请人：OCE TECHNOLOGIES B.V.

  公开号：US20130137805A1

  公开（公告）日：2013-05-30

  The present invention relates to a reusable print medium comprising a substrate and a sacrificial layer. The sacrificial layer contains a hotmelt composition at least comprising an amorphous material. The amorphous material is a resin being a reaction product of a first monomer A, said first monomer A being a polyhydroxyl alcohol comprising X hydroxyl functional groups, wherein X≧2, monomer A optionally comprises a primary or secondary amine functionality; a second monomer B, being an aromatic monocarboxylic acid; a third monomer C, said third monomer C being able to form an ester linkage with an alcohol and/or an amide linkage with a primary or secondary amine; and optionally, a fourth monomer D, being an aromatic monocarboxylic acid different from the second monomer B. The sacrificial layer including the printed image may be removed from the substrate by applying heat. A new sacrificial layer may be applied such that the reusable print medium is ready to be reused. The present invention also relates to a method of manufacturing a reusable print medium according to the present invention, a method of printing and recycling such a print medium and an apparatus for printing and recycling such a print medium.

  本发明涉及一种可重复使用的印刷介质，包括基底和牺牲层。牺牲层含有至少包括非晶态材料的热熔组合物。该非晶态材料是一种树脂，是第一单体A的反应产物，第一单体A是一种聚羟基醇，包括X个羟基官能团，其中X≥2，单体A可选包括一种主链或侧链氨基官能团；第二单体B是一种芳香单羧酸；第三单体C能够与醇形成酯键和/或与一种主链或侧链氨基形成酰胺键；可选地，第四单体D是一种与第二单体B不同的芳香单羧酸。可以通过施加热量从基底中去除包括印刷图像的牺牲层。可以应用新的牺牲层，使可重复使用的印刷介质准备好被重用。本发明还涉及一种制造可重复使用的印刷介质的方法，一种印刷和回收这样的印刷介质的方法，以及一种印刷和回收这样的印刷介质的装置。
• Reusable print medium and method of manufacturing thereof
  申请人：Océ-Technologies B.V.

  公开号：EP2596960A2

  公开（公告）日：2013-05-29

  The present invention relates to a reusable print medium (200) comprising a substrate (201) and a sacrificial layer (202). The sacrificial layer contains a hotmelt composition at least comprising an amorphous material. The amorphous material is a resin being a reaction product of a first monomer A, said first monomer A being a polyhydroxyl alcohol comprising X hydroxyl functional groups, wherein X ≥ 2, monomer A optionally comprises a primary or secondary amine functionality; a second monomer B, being an aromatic monocarboxylic acid; a third monomer C, said third monomer C being able to form an ester linkage with an alcohol and/or an amide linkage with a primary or secondary amine; and optionally, a fourth monomer D, being an aromatic monocarboxylic acid different from the second monomer B. The sacrificial layer including the printed image may be removed from the substrate by applying heat. A new sacrificial layer may be applied such that the reusable print medium is ready to be reused. The present invention also relates to a method of manufacturing a reusable print medium according to the present invention and a method of printing and recycling such a print medium.

  本发明涉及一种可重复使用的打印介质（200），它包括一个基底（201）和一个牺牲层（202）。牺牲层包含一种热熔胶组合物，至少包括一种非晶材料。无定形材料是一种树脂，是第一单体 A 的反应产物，所述第一单体 A 是一种多羟基醇，包含 X 个羟基官能团，其中 X ≥ 2，单体 A 可选择包含伯胺或仲胺官能团；第二单体 B，为芳香族单羧酸； 第三单体 C，所述第三单体 C 能与醇形成酯连接和/或与伯胺或仲胺形成酰胺连接；以及 第四单体 D，为不同于第二单体 B 的芳香族单羧酸。可通过加热将包括印刷图像的牺牲层从基底上去除。然后再涂上一层新的牺牲层，这样可重复使用的打印介质就可以重复使用了。 本发明还涉及根据本发明制造可重复使用打印介质的方法，以及打印和回收这种打印介质的方法。
• HOT MELT INK COMPOSITION COMPRISING A COPOLYESTER AND PROCESS FOR PREPARING A COPOLYESTER
  申请人：OCE-Technologies B.V.

  公开号：EP2726564A2

  公开（公告）日：2014-05-07