N-biphenyl-2-yl-octanamide | 111065-92-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-biphenyl-2-yl-octanamide
• 英文别名: N-Biphenyl-2-yl-octanamid；Octanoic acid biphenyl-2-ylamide；N-(2-phenylphenyl)octanamide
• CAS: 111065-92-0
• 化学式: C₂₀H₂₅NO
• 分子量: 295.425
• InChiKey: CLTPDJWVYAJEKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-biphenyl-2-yl-octanamide 在 三氯氧磷 作用下， 生成 6-heptylphenanthridine
  参考文献：
  名称：

  Buu-Hoi et al., Journal of the Chemical Society, 1957, p. 505,507

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基联苯 、 辛酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以70%的产率得到N-biphenyl-2-yl-octanamide
  参考文献：
  名称：

  Biphenyl versus Phenylpyridazine Derivatives: The Role of the Heterocycle in a Series of Acyl-CoA:Cholesterol Acyl Transferase Inhibitors

  摘要：

  A series of alkylamido- (1) and alkylaminobiphenyl (2) derivatives were synthesized as possible bioisosters of the reported ACAT inhibitors phenylpyridazine analogues (I). Both 1 and 2 were tested on the human ACAT-1 and ACAT-2 isoforms. The amino derivatives 2 were found to be inactive, contrary to the related pyridazine derivatives. By contrast, the ortho-substituted amides 1a and 1d showed an interesting activity. These results support the essential role of the pyridazine nucleus. Modeling studies were also performed.

  DOI：

  10.1021/jm701474c

文献信息

• METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Trustees of Dartmouth College

  公开号：US20140044757A1

  公开（公告）日：2014-02-13

  The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
• METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Trustees of Dartmouth College

  公开号：US20140308340A1

  公开（公告）日：2014-10-16

  The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
• METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF OBESITY, METABOLIC SYNDROME, AND ATHEROSCLEROSIS
  申请人：Trustees of Dartmouth College

  公开号：US20160355824A1

  公开（公告）日：2016-12-08

  The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone or in combination by inhibiting Acyl-CoA: Cholesterol Acyltransferase 1 (ACATI) activity or expression in myeloid cells.
• US9149492B2
  申请人：——

  公开号：US9149492B2

  公开（公告）日：2015-10-06
• US9388413B2
  申请人：——

  公开号：US9388413B2

  公开（公告）日：2016-07-12