5-n-propyl-2,2-dimethyl-1,3benzodioxol | 115328-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 5-n-propyl-2,2-dimethyl-1,3benzodioxol
• 英文别名: 5-n-Propyl-2,2-dimethyl-1,3-benzodioxol；2,2-dimethyl-5-propyl-1,3-benzodioxole
• CAS: 115328-34-2
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: GJLRDKBCXUEYRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-丙基苯-1,2-二醇 在 对甲苯磺酸一水合物 作用下， 以 丙酮 、 苯 为溶剂， 生成 n-Propyl-2,2-dimethyl-1,3-benzodioxol 、 5-n-propyl-2,2-dimethyl-1,3benzodioxol
  参考文献：
  名称：

  Catechol diacetate derivatives for inducing the production of nerve

  摘要：

  一种用于治疗中枢神经系统退行性疾病的药物组合物，可通过诱导神经生长因子的产生和分泌进行治疗，包含一种活性成分，即具有以下结构式的儿茶酚衍生物##STR1##其中R.sub.6是具有2至5个碳原子的较低的烷基基团。这些儿茶酚衍生物对中枢神经系统的退行性疾病，包括老年型阿尔茨海默病的预防和治疗效果。

  公开号：

  US04985458A1

文献信息

• [EN] BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY<br/>[FR] ACTIVATEURS BIO-INSPIRÉS DES PROTÉASOMES AYANT UNE ACTIVITÉ ANTI-ÂGE
  申请人：NATIONAL HELLENIC RES FOUNDATION

  公开号：WO2019171088A1

  公开（公告）日：2019-09-12

  The present invention relates to novel bio-inspired hybrid compounds of formula I which act as proteasome activators and exhibit anti-ageing activity, as well as methods for their synthesis. These hybrid compounds combine the structural features of hydroxytyrosol and the natural antioxidant vitamin E or its bioisosteres in one molecular scaffold. The compounds of formula I, which include structural proteasome activators (activation by stereochemical interaction), can be used in the production of anti-ageing products, such as cosmetic preparations. Additionally, they can be used in conditions and diseases where the proteasome is down-regulated, as well as proteasome-activation control compounds.

  本发明涉及新型生物启发的混合化合物，其化学式为I，作为蛋白酶体激活剂并具有抗衰老活性，以及其合成方法。这些混合化合物将羟基酪醇和天然抗氧化维生素E或其生物同系物的结构特征结合在一个分子支架中。化合物I的结构包括结构蛋白酶体激活剂（通过立体化学相互作用激活），可用于生产抗衰老产品，如化妆品制剂。此外，它们可以在蛋白酶体被下调的情况和疾病中使用，以及用作蛋白酶体激活控制化合物。
• Catechol derivatives, and preventive and remedial preparations for
  申请人：Mitsui Toatsu Chemicals, Incorporated

  公开号：US05214034A1

  公开（公告）日：1993-05-25

  Catechol derivatives which relate to the production of nerve growth factor in particular tissues of brain are disclosed. Methods for the synthesis, data on the physiological activity, and data on the toxicity of these derivatives as well as examples of preparation for their administration are also disclosed. The disclosed derivatives provide preventive and remedial effect for regressive disorders in the central nervous system including senile dementia of Alzheimer type.

  本文披露了与大脑特定组织中神经生长因子生产相关的邻苯二酚衍生物。披露了合成方法、生理活性数据、毒性数据以及其治疗剂量制备的示例。这些衍生物具有预防和治疗中枢神经系统退行性疾病，包括阿尔茨海默病的效果。
• Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0261977A2

  公开（公告）日：1988-03-30

  Catechol derivatives which relate to the production of group. nerve growth factor in particular tissues of the brain are disclosed, as are methods for their synthesis, data on their physiological activity, and data on the toxicity of these derivatives. Examples of preparation for their administration are also disclosed. The disclosed derivatives provide preventive and remedial effects for regressive disorders in the central nervous system including senile dementia of Alzheimer type: a preparation for this purpose includes a catechol derivative having the formula: wherein R is two hydrogen atoms, two acyl groups, a -CO-group. -CO•CO- group, or -C(CH3)2- group, and wherein R1 and R2 are each independently a hydrogen atom or lower alkyl

  公开了与在大脑特定组织中产生神经生长因子有关的儿茶酚衍生物，以及它们的合成方法、有关其生理活性的数据和有关这些衍生物毒性的数据。 还公开了用于给药的制剂实例。 公开的衍生物对包括阿尔茨海默型老年痴呆症在内的中枢神经系统退行性疾病具有预防和治疗作用：用于此目的的制剂包括具有以下式子的儿茶酚衍生物： 其中R为两个氢原子、两个酰基、一个-CO-基团、-CO-CO-基团或-C(CH3)2-基团，且R1和R2各自独立地为氢原子或低级烷基。
• Method of forming inorganic nanocages
  申请人：Research Foundation of the City University of New York

  公开号：US10688556B2

  公开（公告）日：2020-06-23

  Nanocages are formed by etching nancubes. The nanocubes are added to an aqueous system having an amphiphilic lipid dissolved in an organic solvent (e.g. a hydrophobic alcohol) to form reverse micelles. As the water evaporates the micelles shrink as etching of the flat surface of the nanocubes occurs. In this fashion hollow nanocages are produced. In one embodiment, the nanocage is covalently attached to a polymer shell (e.g. a dextran shell).

  纳米笼是通过蚀刻纳米立方体形成的。 将纳米立方体添加到具有溶解在有机溶剂（如疏水性酒精）中的两性脂质的水体系中，形成反向胶束。 当水蒸发时，胶束收缩，纳米管的扁平表面发生蚀刻。 这样就产生了空心纳米笼。 在一个实施方案中，纳米笼与聚合物外壳（如葡聚糖外壳）共价连接。
• METHOD OF FORMING INORGANIC NANOCAGES
  申请人：Research Foundation of the City University of New York

  公开号：US20170282252A1

  公开（公告）日：2017-10-05

  Nanocages are formed by etching nancubes. The nanocubes are added to an aqueous system having an amphiphilic lipid dissolved in an organic solvent (e.g. a hydrophobic alcohol) to form reverse micelles. As the water evaporates the micelles shrink as etching of the flat surface of the nanocubes occurs. In this fashion hollow nanocages are produced. In one embodiment, the nanocage is covalently attached to a polymer shell (e.g. a dextran shell).