NCGC00010428-03 | 959489-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: NCGC00010428-03
• 英文别名: 6-(benzo[d][1,3]dioxol-5-yl)-N-(furan-2-ylmethyl)-N-methylquinazolin-4-amine；6-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine；6-(1,3-benzodioxol-5-yl)-N-(furan-2-ylmethyl)-N-methylquinazolin-4-amine
• CAS: 959489-38-4
• 化学式: C₂₁H₁₇N₃O₃
• 分子量: 359.384
• InChiKey: PBJIOVQCYBRCRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-溴-4-羟基喹唑啉 在 四(三苯基膦)钯 、 sodium carbonate 、 N,N-二甲基苯胺 、 N,N-二异丙基乙胺 、 三氯氧磷 作用下， 以 乙二醇二甲醚 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 3.5h， 生成 NCGC00010428-03
  参考文献：
  名称：

  Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)

  摘要：

  Continued examination of substituted 6-arylquinazolin-4-amines as Clk4 inhibitors resulted in selective inhibitors of Clk1, Clk4, Dyrk1A and Dyrk1B. Several of the most potent inhibitors were validated as being highly selective within a comprehensive kinome scan. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2011.02.114

文献信息

• [EN] QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE<br/>[FR] DÉRIVÉS DE LA QUINAZOLIN-4-AMINE; ET MÉTHODES D'UTILISATION
  申请人：US HEALTH

  公开号：WO2011041655A1

  公开（公告）日：2011-04-07

  Disclosed herein are novel quinazolin-4-amine derivatives that are inhibitors of Clk1, Clk2, Clk3, Clk4, or Dyrk1A. Also disclosed are quinazolin-4-amine derivatives as potent and selective inhibitors of Clk1, Clk4, and Dyrk1A. These agents provide useful tools for the study of Clk1, Clk4 and Dyrk1A and their respective roles in pre-mRNA splicing. Methods of treating Clk1, Clk2, Clk4, or Dyrk1A kinase mediated disorders with certain quinazolin-4-amine derivatives are also disclosed.

  本文公开了新型的喹唑啉-4-胺衍生物，它们是Clk1、Clk2、Clk3、Clk4或Dyrk1A的抑制剂。还公开了喹唑啉-4-胺衍生物作为Clk1、Clk4和Dyrk1A的有效和选择性抑制剂。这些药剂为研究Clk1、Clk4和Dyrk1A及其在前mRNA剪接中的作用提供了有用的工具。本文还公开了使用某些喹唑啉-4-胺衍生物治疗Clk1、Clk2、Clk4或Dyrk1A激酶介导的疾病的方法。
• Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)
  作者：Andrew S. Rosenthal、Cordelle Tanega、Min Shen、Bryan T. Mott、James M. Bougie、Dac-Trung Nguyen、Tom Misteli、Douglas S. Auld、David J. Maloney、Craig J. Thomas

  DOI：10.1016/j.bmcl.2011.02.114

  日期：2011.5

  Continued examination of substituted 6-arylquinazolin-4-amines as Clk4 inhibitors resulted in selective inhibitors of Clk1, Clk4, Dyrk1A and Dyrk1B. Several of the most potent inhibitors were validated as being highly selective within a comprehensive kinome scan. Published by Elsevier Ltd.