2-Morpholin-4-ylethanethioamide;hydrochloride | 82586-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-Morpholin-4-ylethanethioamide;hydrochloride
• CAS: 82586-63-8
• 化学式: C6H13ClN2OS
• 分子量: 196.7
• InChiKey: NHWRJTSQLUXDLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.03
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  70.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Thiazole derivatives as H2-receptor antagonists
  申请人：ELI LILLY AND COMPANY

  公开号：EP0083186A2

  公开（公告）日：1983-07-06

  and their pharmaceutically-acceptable salts are effective anti-ulcer agents.

  及其药学上可接受的盐类是有效的抗溃疡剂。
• Thiazole derivatives, process for their preparation and pharmaceutical compositions containing them
  申请人：ELI LILLY AND COMPANY

  公开号：EP0091220A2

  公开（公告）日：1983-10-12

  N-alkenyl (or N-alkynyl)-N'-[2-(aminoalkyl)-4-thiazolyl- methylthioalkyl]guanidines, thioureas, ethenediamines and related compounds of the following formula wherein each of R' and R2 are individually H or (C1-C4)-alkyl, one of R' and R2 can be benzyl or benzoyl, and when taken together with the nitrogen to which they are attached, form a saturated heterocyclic ring containing from 5 to 7 ring atoms including 1 or 2 heteroatoms; except that only one of R' and R2 can be H when Z is CH2; R3 is H or (C1-C3)alkyl; Z is 0, S or CH2; n is 2 or 3 when Z is S or 0 and is 1, 2 or 3 when Z is CH2; m is 1. 2 or 3; R6 is H or CH3; wherein A is N-CN, N-NO2, CH-NO2, S, 0, NH, N-(C1-C4)alkyl, N-SO2-aryl, N-SO2-(C1-C4)alkyl, N-CO-NH2, N-CO-(C1-C4)alkyl, N-C02(C,-C4)alkyl, CH-S02-aryl or CH-SO2-(C1-C4)alkyl, wherein aryl is phenyl, halophenyl, (C1-C4)alkylphenyl or (C1-C4)alkyloxy- phenyl; and R is (C2-C4)alkenyl or (C2-C4)alkynyl; and R8 and R9 are individually H, CH3 or C2H5, with the proviso that the total number of carbon atoms in the group CR8R9R be less than 7; or a pharmaceutically-acceptable salt thereof. The compounds are H2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.

  N-烯基（或 N-炔基）-N'-[2-(氨基烷基)-4-噻唑基-甲硫基烷基]胍类、硫脲类、乙烯二胺类及下式的相关化合物 其中，R'和 R2 分别为 H 或（C1-C4）-烷基，R'和 R2 中的一个可以是苄基或苯甲酰基，当它们与所连接的氮结合在一起时，形成一个含有 5 至 7 个环原子（包括 1 或 2 个杂原子）的饱和杂环；但当 Z 为 CH2 时，R'和 R2 中只有一个可以是 H； R3 是 H 或 (C1-C3) 烷基； Z 是 0、S 或 CH2； 当 Z 为 S 或 0 时，n 为 2 或 3；当 Z 为 CH2 时，n 为 1、2 或 3； m 是 1、2 或 3； R6 是 H 或 CH3； 其中 A 是 N-CN、N-NO2、CH-NO2、S、0、NH、N-(C1-C4)烷基、N-SO2-芳基、N-SO2-(C1-C4)烷基、N-CO-NH2、N-CO-(C1-C4)烷基、N-C02(C,-C4)烷基、CH-S02-芳基或 CH-SO2-(C1-C4)烷基，其中芳基是苯基、卤代苯基、(C1-C4)烷基苯基或(C1-C4)烷氧基苯基；R为(C2-C4)烯基或(C2-C4)炔基；R8和R9分别为H、CH3或C2H5，但CR8R9R基团中的碳原子总数应少于7；或其药学上可接受的盐。这些化合物是 H2 受体拮抗剂，可用于抑制哺乳动物的胃酸分泌。
• Improvements in or relating to 2,4-disubstituted thiazole derivatives
  申请人：ELI LILLY AND COMPANY

  公开号：EP0049618B1

  公开（公告）日：1985-08-14
• US4382090A
  申请人：——

  公开号：US4382090A

  公开（公告）日：1983-05-03
• US4375547A
  申请人：——

  公开号：US4375547A

  公开（公告）日：1983-03-01