1-benzo[b]thiophen-3-yl-3-[1-(4-nitro-2-trifluoromethylphenyl)-(S)-pyrrolidin-3-ylamino]propan-1-one | 1291057-79-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-benzo[b]thiophen-3-yl-3-[1-(4-nitro-2-trifluoromethylphenyl)-(S)-pyrrolidin-3-ylamino]propan-1-one
• 英文别名: 1-(1-benzothiophen-3-yl)-3-[[(3S)-1-[4-nitro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl]amino]propan-1-one
• CAS: 1291057-79-8
• 化学式: C₂₂H₂₀F₃N₃O₃S
• 分子量: 463.48
• InChiKey: QUZXJJNRZJWDOO-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1-benzo[b]thiophen-3-yl-3-[1-(4-nitro-2-trifluoromethylphenyl)-(S)-pyrrolidin-3-ylamino]propan-1-one 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以18%的产率得到1-(benzo[b]thiophen-3-yl)-3-[1-(4-nitro-2-trifluoromethylphenyl)-(S)-pyrrolidin-3-ylamino]propan-1-ol
  参考文献：
  名称：

  New 1-Aryl-3-Substituted Propanol Derivatives as Antimalarial Agents

  摘要：

  本文描述了一些新型1-芳基-3-取代丙醇衍生物的合成及其对P. falciparum 3D7株的体外抗疟活性。测试的十二种化合物中，有的显示出IC50低于1 μM。这些化合物还在小鼠J774巨噬细胞中进行了细胞毒性测试。最活跃的化合物在对P. berghei进行的4天抑制测试中进行了评估。化合物12在50 mg/kg/day的剂量下抑制了超过50%的寄生虫生长。此外，进行了FBIT测试以测量抑制铁卟啉生物结晶的能力。这些数据表明，1-芳基-3-取代丙醇衍生物作为抗疟疾的新治疗选择具有良好的前景。

  DOI：

  10.3390/molecules14104120
• 作为产物：
  描述：

  2-氟-5-硝基三氟甲苯 在 盐酸 、 potassium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 122.0h， 生成 1-benzo[b]thiophen-3-yl-3-[1-(4-nitro-2-trifluoromethylphenyl)-(S)-pyrrolidin-3-ylamino]propan-1-one
  参考文献：
  名称：

  Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

  摘要：

  We report benzo[b]thiophene derivatives synthesized according 10 a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT(7)R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results slowed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

  DOI：

  10.1021/jm2000773

文献信息

• Novel Benzo[<i>b</i>]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action
  作者：Luis Berrade、Bárbara Aisa、María J. Ramirez、Silvia Galiano、Salvatore Guccione、Lise Román Moltzau、Finn Olav Levy、Ferdinando Nicoletti、Giuseppe Battaglia、Gemma Molinaro、Ignacio Aldana、Antonio Monge、Silvia Perez-Silanes

  DOI：10.1021/jm2000773

  日期：2011.4.28

  We report benzo[b]thiophene derivatives synthesized according 10 a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT(7)R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results slowed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.
• New 1-Aryl-3-Substituted Propanol Derivatives as Antimalarial Agents
  作者：Silvia Pérez-Silanes、Luis Berrade、Rory García–Sánchez、Adela Mendoza、Silvia Galiano、Berta Pérez-Solórzano、Juan Nogal-Ruiz、Antonio Martínez-Fernández、Ignacio Aldana、Antonio Monge

  DOI：10.3390/molecules14104120

  日期：——

  This paper describes the synthesis and in vitro antimalarial activity against a P. falciparum 3D7 strain of some new 1-aryl-3-substituted propanol derivatives. Twelve of the tested compounds showed an IC50 lower than 1 μM. These compounds were also tested for cytotoxicity in murine J774 macrophages. The most active compounds were evaluated for in vivo activity against P. berghei in a 4-day suppressive test. Compound 12 inhibited more than 50% of parasite growth at a dose of 50 mg/kg/day. In addition, an FBIT test was performed to measure the ability to inhibit ferriprotoporphyrin biocrystallization. This data indicates that 1-aryl-3-substituted propanol derivatives hold promise as a new therapeutic option for the treatment of malaria.

  本文描述了一些新型1-芳基-3-取代丙醇衍生物的合成及其对P. falciparum 3D7株的体外抗疟活性。测试的十二种化合物中，有的显示出IC50低于1 μM。这些化合物还在小鼠J774巨噬细胞中进行了细胞毒性测试。最活跃的化合物在对P. berghei进行的4天抑制测试中进行了评估。化合物12在50 mg/kg/day的剂量下抑制了超过50%的寄生虫生长。此外，进行了FBIT测试以测量抑制铁卟啉生物结晶的能力。这些数据表明，1-芳基-3-取代丙醇衍生物作为抗疟疾的新治疗选择具有良好的前景。