α-(3,5-Dinitrophenyl)-acetyl chloride | 408527-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-(3,5-Dinitrophenyl)-acetyl chloride
• 英文别名: α-(3,5-Dinitrophenyl)acetyl chloride；alpha-(3,5-Dinitrophenyl)acetyl chloride；2-(3,5-dinitrophenyl)acetyl chloride
• CAS: 408527-33-3
• 化学式: C₈H₅ClN₂O₅
• 分子量: 244.591
• InChiKey: VBOZFGKQYUPJLJ-UHFFFAOYSA-N

物化性质

• 沸点：
  405.0±35.0 °C(Predicted)
• 密度：
  1.583±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  α-(3,5-Dinitrophenyl)-acetyl chloride 、 5-(2-hydroxy-4-methoxybenzoyl)-1-o-tolylphenylpyridin-2(1H)-one 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 2-(3,5-dinitrophenyl)acetate
  参考文献：
  名称：

  Design and synthesis of novel 2′-hydroxy group substituted 2-pyridone derivatives as anticancer agents

  摘要：

  We have synthesized a series of novel 2-pyridone derivatives with 1,2,3-triazole and evaluated their antitumor activities in vitro. The bioassays showed that the majority of the resultant compounds exerted inhibitory effects on six human cancer cell lines to various extents. In particular, compound 10k showed the best anti-tumor activities (IC50 values of A549, HeLa and SW480 cancer cell lines were 0.86 +/- 0.17 mu M, 0.54 +/- 0.23 mu M and 0.21 +/- 0.13 mu M, respectively). (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.06.046

文献信息

• 1-Thiadiazolyl-6-acyloxytetrahydropyrimidinone herbicides
  申请人：Velsicol Chemical Corporation

  公开号：US04006009A1

  公开（公告）日：1977-02-01

  Disclosed are new compounds of the formula ##STR1## wherein R.sup.1 is selected from the group consisting of alkyl, alkenyl, haloalkyl, alkoxy, alkylthio, alkylsulfonyl and alkylsulfinyl; R.sup.2 is selected from the group consisting of alkyl, alkenyl, haloalkyl and ##STR2## wherein R.sup.3 and R.sup.4 are each selected from the group consisting of hydrogen and alkyl; and R.sup.5 is selected from the group consisting of alkyl, haloalkyl, alkenyl, alkynyl, alkoxyalkyl, cycloalkyl and ##STR3## WHEREIN X is selected from the group consisting of alkyl, halogen, haloalkyl, nitro, cyano and alkoxy, and m and n are each integers from 0 to 3. The subject compounds are useful as herbicides.

  揭示了新的化合物，其化学式为##STR1##其中R.sup.1选自由烷基、烯基、卤代烷基、烷氧基、烷基硫醚、烷基磺酰基和烷基亚磺酰基组成的群体；R.sup.2选自由烷基、烯基、卤代烷基和##STR2##其中R.sup.3和R.sup.4各自选自氢和烷基的群体；R.sup.5选自由烷基、卤代烷基、烯基、炔基、烷氧基烷基、环烷基和##STR3##其中X选自由烷基、卤素、卤代烷基、硝基、氰基和烷氧基，m和n分别为0到3的整数。这些化合物可用作除草剂。
• US4004912A
  申请人：——

  公开号：US4004912A

  公开（公告）日：1977-01-25
• US4006009A
  申请人：——

  公开号：US4006009A

  公开（公告）日：1977-02-01
• Design and synthesis of novel 2′-hydroxy group substituted 2-pyridone derivatives as anticancer agents
  作者：Zhiliang Lv、Yikai Zhang、Mingfeng Zhang、Huan Chen、Zhenliang Sun、Dongping Geng、Chunjuan Niu、Ke Li

  DOI：10.1016/j.ejmech.2013.06.046

  日期：2013.9

  We have synthesized a series of novel 2-pyridone derivatives with 1,2,3-triazole and evaluated their antitumor activities in vitro. The bioassays showed that the majority of the resultant compounds exerted inhibitory effects on six human cancer cell lines to various extents. In particular, compound 10k showed the best anti-tumor activities (IC50 values of A549, HeLa and SW480 cancer cell lines were 0.86 +/- 0.17 mu M, 0.54 +/- 0.23 mu M and 0.21 +/- 0.13 mu M, respectively). (C) 2013 Elsevier Masson SAS. All rights reserved.