4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]benzenesulfonamide | 922711-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]benzenesulfonamide
• 英文别名: 4-Chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]benzene-1-sulfonamide
• CAS: 922711-38-4
• 化学式: C₁₃H₁₁Cl₂NO₃S
• 分子量: 332.207
• InChiKey: PXTPLILUPXXCNE-UHFFFAOYSA-N

物化性质

• 沸点：
  495.3±55.0 °C(Predicted)
• 密度：
  1.536±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]benzenesulfonamide 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 生成 4-chloro-N-[5-chloro-2-(chloromethyl)phenyl]benzenesulfonamide
  参考文献：
  名称：

  WO2007/14054

  摘要：

  公开号：
• 作为产物：
  描述：

  C₁₄H₁₁Cl₂NO₄S 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以77%的产率得到4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]benzenesulfonamide
  参考文献：
  名称：

  Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase

  摘要：

  The synthesis and gamma-secretase inhibition data for a series of nitrogen-appended N-alkylsulfonamides (11-47) are described. Inhibition of brain A beta in transgenic mice was demonstrated by two of these compounds (23 and 44). (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.105

文献信息

• NOVEL SULFONAMIDE COMPOUNDS AND USES THEREOF
  申请人：MERCK & CO., INC.

  公开号：EP1159263A1

  公开（公告）日：2001-12-05
• [EN] NOVEL SULFONAMIDE COMPOUNDS AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSES DE SULFONAMIDE ET UTILISATIONS CORRESPONDANTES
  申请人：MERCK & CO INC

  公开号：WO2000050391A1

  公开（公告）日：2000-08-31

  In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid β protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.
• [EN] BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR<br/>[FR] INHIBITEUR BENZENESULFONAMIDE DE RECEPTEUR DE CHIMIOKINE CCR2
  申请人：GLAXO GROUP LIMTED

  公开号：WO2007014054A2

  公开（公告）日：2007-02-01

  [EN] Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a combination thereof, as well as compositions of methods of use of the compound, wherein R¹, R², R³, and m are described herein.
  [FR] L'invention concerne des composés de formule (I): ou un sel acceptable sur le plan pharmaceutique, un solvate ou une combinaison de ceux-ci, ainsi que des compositions de procédés d'utilisation de ces composés, R¹, R², R³ et m y étant décrits.
• WO2007/14054
  申请人：——

  公开号：——

  公开（公告）日：——
• Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase
  作者：Carl P. Bergstrom、Charles P. Sloan、Henry H. Wang、Michael F. Parker、David W. Smith、Ming Zheng、Steven B. Hansel、Craig T. Polson、Lauren E. Barber、Isia Bursuker、Valerie L. Guss、Jason A. Corsa、Donna M. Barten、Kevin M. Felsenstein、Susan B. Roberts

  DOI：10.1016/j.bmcl.2007.10.105

  日期：2008.1

  The synthesis and gamma-secretase inhibition data for a series of nitrogen-appended N-alkylsulfonamides (11-47) are described. Inhibition of brain A beta in transgenic mice was demonstrated by two of these compounds (23 and 44). (C) 2007 Elsevier Ltd. All rights reserved.