2-甲基-4-苄氧基羰基丁酸 | 64624-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-甲基-4-苄氧基羰基丁酸
• 英文名称: 2-methyl-4-benzyloxycarbonylbutyric acid
• 英文别名: 2-Methyl-5-oxo-5-phenylmethoxypentanoic acid
• CAS: 64624-16-4
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: UJOPBFSFUMVDJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-甲基-4-苄氧基羰基丁酸 在 palladium-carbon 氢气 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 4-methoxycarbonylpentanoic acid
  参考文献：
  名称：

  Hydroxycarbamoylalkylacylpipecolic acid compounds

  摘要：

  新的羟基氨基甲酰烷基酰基吡啶甲酸衍生物具有一般公式##STR1##，可用作血管紧张素转换酶抑制剂。

  公开号：

  US04154937A1

文献信息

• METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY
  申请人：VOHRA Rahul

  公开号：US20090082368A1

  公开（公告）日：2009-03-26

  Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.

  揭示了一种调节神经生长因子及其前体与神经营养受体相互作用的组合物。还揭示了使用该发明的组合物的方法，包括给药方法。
• Carboxyacylproline derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04052511A1

  公开（公告）日：1977-10-04

  New carboxyalkylacylamino acids which are derivatives of proline, pipecolic acid and azetidine-2-carboxylic acid and have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

  新的羧基烷基酰胺酸是脯氨酸、吡啶甲酸和氮杂环戊二酸的衍生物，其通式为##STR1##，可用作肾素转化酶抑制剂。
• Synthesis and GGCT Inhibitory Activity of <i>N</i>-Glutaryl-L-alanine Analogues
  作者：Hiromi Ii、Tatsuhiro Yoshiki、Naoyuki Hoshiya、Jun’ichi Uenishi

  DOI：10.1248/cpb.c16-00167

  日期：——

  cycle to release 5-oxoproline and amino acid. Eighteen N-acyl-L-alanine analogues including eleven new compounds have been synthesized and examined for their inhibitory activity against recombinant human GGCT protein. Simple N-glutaryl-L-alanine was found to be the most potent inhibitor for GGCT. Other N-glutaryl-L-alanine analogues having methyl and dimethyl substituents at the 2-position were moderately

  γ-谷氨酰环转移酶（GGCT）是一种重要的酶，可在γ-谷氨酰循环中裂解γ-谷氨酰氨基酸，从而释放出5-氧代脯氨酸和氨基酸。已合成了包括11种新化合物在内的18种N-酰基-L-丙氨酸类似物，并研究了其对重组人GGCT蛋白的抑制活性。发现简单的N-谷氨酰-L-丙氨酸是GGCT最有效的抑制剂。其他在2位具有甲基和二甲基取代基的N-戊二烯基-L-丙氨酸类似物是中等有效的，而N-（3R-氨基戊二烯基）-L-丙氨酸是在3-位具有（R）-氨基的底物。相反，在3-氮杂戊二烯基碳上具有N-甲基取代基的底物或N-（N-甲基-3-氮杂戊二烯基）-L-丙氨酸反过来表现出优异的抑制性能。
• PROCESS FOR MANUFACTURING EXTREMELY PURE BENZAZEPINE DERIVATIVES
  申请人：GERDES Klaus

  公开号：US20090326219A1

  公开（公告）日：2009-12-31

  A process for the production of extremely pure galanthamine or extremely pure galanthamine derivatives, a start is made from racemic bromine narwedine, which is debrominated under palladium catalysis. In this case, the working-up of the reaction mixture, which is carried out in the presence of oxygen or peroxides so that the palladium catalyst in an insoluble form is converted into an easily separable form, is essential. The further reaction is carried out by reduction of enantiomer-pure narwedine to form enantiomer-pure galanthamine, whereby it is then alkylated or dealkylated so that a corresponding substitution on the ring-nitrogen atom is achieved. By further purification, such as recrystallization, residual portions of palladium of below 5 ppm are achieved, so that direct use as a pharmaceutical raw material is made possible.

  一种生产极纯的风信子碱或其衍生物的方法，首先从外消旋溴化纳尔维丁开始，通过钯催化去溴化。在这种情况下，反应混合物的处理必须在氧气或过氧化物的存在下进行，以便将钯催化剂转化为易于分离的不溶形式。进一步的反应是将对映纯的纳尔维丁还原成对映纯的风信子碱，然后通过烷基化或去烷基化使环氮原子上发生相应的取代。通过进一步的纯化，如重结晶，可以实现钯的残留量低于5 ppm，从而使其可以直接用作药用原料。
• A LARGE SCALE PROCESS FOR PREPARING POLY (GLUTAMYL-GLUTAMATE) CONJUGATES
  申请人：NITTO DENKO CORPORATION

  公开号：US20160074524A1

  公开（公告）日：2016-03-17

  Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.

  本文描述了制造生物相容性水溶性聚合物共轭物的过程。具体而言，描述了制造可以用于各种药物传递应用的大规模制造聚（L-γ-谷氨酰-谷氨酸）共轭物的过程。