2-ethylhexanoic acid hydrazide | 41632-11-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-ethylhexanoic acid hydrazide
• 英文别名: 2-Ethylhexanohydrazide；2-ethylhexanehydrazide
• CAS: 41632-11-5
• 化学式: C₈H₁₈N₂O
• 分子量: 158.244
• InChiKey: WOTFFLFEMKUWOF-UHFFFAOYSA-N

物化性质

• 熔点：
  91-93 °C
• 沸点：
  294.5±9.0 °C(Predicted)
• 密度：
  0.927±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2-ethylhexanoic acid hydrazide 在 盐酸 、 sodium nitrite 作用下， 以 水 、 甲苯 为溶剂， 反应 0.03h， 生成 3-heptyl isocyanate
  参考文献：
  名称：

  [EN] FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES
  [FR] SYNTHÈSE CHIMIQUE EN FLUX D'ISOCYANATES

  摘要：

  该披露提供了诸如流动化学等安全环保的方法，用于合成异氰酸酯，例如亚甲基二苯基二异氰酸酯、甲苯二异氰酸酯、己二胺二异氰酸酯、异佛尔酮二异氰酸酯和四甲基二异氰酸酯。

  公开号：

  WO2021119606A1
• 作为产物：
  描述：

  2-乙基-己酸稀土盐 在 盐酸 、 肼 作用下， 以 甲醇 为溶剂， 反应 8.0h， 生成 2-ethylhexanoic acid hydrazide
  参考文献：
  名称：

  [EN] FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES
  [FR] SYNTHÈSE CHIMIQUE EN FLUX D'ISOCYANATES

  摘要：

  该披露提供了诸如流动化学等安全环保的方法，用于合成异氰酸酯，例如亚甲基二苯基二异氰酸酯、甲苯二异氰酸酯、己二胺二异氰酸酯、异佛尔酮二异氰酸酯和四甲基二异氰酸酯。

  公开号：

  WO2021119606A1

文献信息

• Synthesis of acylhydrazones from lupane and 19β,28-epoxy-18α-oleanane 2,3-seco-aldehydonitriles
  作者：I. A. Tolmacheva、N. V. Galaiko、V. V. Grishko

  DOI：10.1007/s10600-010-9520-x

  日期：2010.3

  2,3-seco-Triterpene acylhydrazones, which are interesting as new biologically active compounds, were prepared by reaction of lupane and 19β,28-epoxy-18α-oleanane 2,3-seco-aldehydonitriles with acylated hydrazines.

  通过将羽扇豆和 19β,28-环氧-18α-齐墩果烷 2,3-seco-aldehydonitriles 与酰化肼反应，制备了 2,3-seco-三萜酰肼，这是一种具有生物活性的新化合物。
• METHOD FOR MANUFACTURING RUBBER COMPOSITION, AND RUBBER COMPOSITION
  申请人：Bridgestone Corporation

  公开号：EP3196232A1

  公开（公告）日：2017-07-26

  Provided is a method for producing a rubber composition that includes a rubber component (A) including natural rubber, at least one filler (B) selected from an inorganic filler and carbon black, and a monohydrazide compound (C) supported on a solid. The monohydrazide compound (C) is represented by general formula (I): R-CONHNH2, where R represents an alkyl group having from 1 to 30 carbon atoms, a cycloalkyl group having from 3 to 30 carbon atoms, or an aryl group. The method comprises compounding in an optional preliminary compounding stage and a plurality of compounding stages, and adding the monohydrazide compound (C) supported on the solid and kneading in the preliminary compounding stage and/or a first compounding stage. Also provided is a rubber composition produced with this method.

  本发明提供了一种生产橡胶组合物的方法，该组合物包括天然橡胶在内的橡胶成分（A）、至少一种选自无机填料和炭黑的填料（B）以及支撑在固体上的单酰肼化合物（C）。单酰肼化合物 (C) 由通式 (I) 表示：R-CONHNH2，其中 R 代表具有 1 至 30 个碳原子的烷基、具有 3 至 30 个碳原子的环烷基或芳基。该方法包括在任选的初步混炼阶段和多个混炼阶段中进行混炼，并在初步混炼阶段和/或第一混炼阶段中加入支撑在固体上的单酰肼化合物（C）并进行捏合。此外，还提供了一种用该方法生产的橡胶组合物。
• Method for producing rubber composition, and rubber composition
  申请人：BRIDGESTONE CORPORATION

  公开号：US10087292B2

  公开（公告）日：2018-10-02

  Provided is a method for producing a rubber composition that includes a rubber component (A) including natural rubber, at least one filler (B) selected from an inorganic filler and carbon black, and a monohydrazide compound (C) supported on a solid. The monohydrazide compound (C) is represented by general formula (I): R—CONHNH2, where R represents an alkyl group having from 1 to 30 carbon atoms, a cycloalkyl group having from 3 to 30 carbon atoms, or an aryl group. The method comprises compounding in an optional preliminary compounding stage and a plurality of compounding stages, and adding the monohydrazide compound (C) supported on the solid and kneading in the preliminary compounding stage and/or a first compounding stage. Also provided is a rubber composition produced with this method.

  本发明提供了一种生产橡胶组合物的方法，该组合物包括天然橡胶在内的橡胶成分（A）、至少一种选自无机填料和炭黑的填料（B）以及支撑在固体上的单酰肼化合物（C）。单酰肼化合物 (C) 由通式 (I) 表示：R-CONHNH2，其中 R 代表具有 1 至 30 个碳原子的烷基、具有 3 至 30 个碳原子的环烷基或芳基。该方法包括在任选的初步混炼阶段和多个混炼阶段中进行混炼，并在初步混炼阶段和/或第一混炼阶段中加入支撑在固体上的单酰肼化合物（C）并进行捏合。此外，还提供了一种用该方法生产的橡胶组合物。
• N′, N′-dialkylhydrazides as inhibitors of acid corrosion of steel
  作者：M. G. Shcherban’、T. D. Batueva、A. V. Radushev

  DOI：10.1134/s1070427209010121

  日期：2009.1

  The effect of N', N'-dialkylhydrazides of aliphatic carboxylic acids of the general formula C(4)H(9)CH(C(2)H(5)) C(O)NHN(R)(2) on the corrosion behavior of St. 20 steel in 0.1 and 1 M HCl was studied by electrochemical and gravimetric methods.
• Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives
  作者：Fabrizio Carta、Alessio Innocenti、Rebecca A. Hall、Fritz A. Mühlschlegel、Andrea Scozzafava、Claudiu T. Supuran

  DOI：10.1016/j.bmcl.2011.02.057

  日期：2011.4

  The inhibition of the beta-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) and Candida albicans (Nce103) with a series of 25 branched aliphatic and aromatic carboxylates has been investigated. Human isoforms hCA I and II were also included in the study for comparison. Aliphatic carboxylates were generally millimolar hCA I and II inhibitors and low micromolar/submicromolar beta-CA inhibitors. Aromatic carboxylates were micromolar inhibitors of the four enzymes but some of them showed low nanomolar activity against the fungal pathogenic enzymes. 4-Hydroxy-and 4-methoxy-benzoate inhibited Can2 with K(I)s of 9.5-9.9 nM. The methyl esters, hydroxamates, hydrazides and carboxamides of some of these derivatives were also effective inhibitors of the alpha- and beta-CAs investigated here. (C) 2011 Elsevier Ltd. All rights reserved.