2,8-bis(4-chlorophenyl)-4-(4-methoxyphenyl)-1,7-naphthyridine | 1258539-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,8-bis(4-chlorophenyl)-4-(4-methoxyphenyl)-1,7-naphthyridine
• 英文别名: 2,8-Bis(4-chlorophenyl)-4-(4-methoxyphenyl)-1,7-naphthyridine
• CAS: 1258539-06-8
• 化学式: C₂₇H₁₈Cl₂N₂O
• 分子量: 457.359
• InChiKey: JAFNOFTTZWSEDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-isocyano-4-[(E)-2-methoxy-1-(4-methoxyphenyl)ethenyl]pyridine 、 4-chlorophenyl lithium 以 乙二醇二甲醚 为溶剂， 反应 3.0h， 以46%的产率得到2,8-bis(4-chlorophenyl)-4-(4-methoxyphenyl)-1,7-naphthyridine
  参考文献：
  名称：

  Synthesis of 2,4,8-Trisubstituted 1,7-Naphthyridines by the Reaction of 4-(1-Aryl-2-methoxyethenyl)-3-isocyanopyridines with Excess Organolithiums

  摘要：

  AbstractA convenient method for the synthesis of 2,4,8‐trisubstituted 1,7‐naphthyridines 6 by the reaction of (E)‐4‐(1‐aryl‐2‐methoxyethenyl)‐3‐isocyanopyridines 4, which could be easily prepared from commercially available 3‐aminopyridine via aroylation of lithium (4‐lithiopyridin‐3‐yl)pivalamide with N‐methoxy‐N‐methylbenzamides, with excess organolithiums has been developed.

  DOI：

  10.1002/hlca.201000214

文献信息

• Synthesis of 2,4,8-Trisubstituted 1,7-Naphthyridines by the Reaction of 4-(1-Aryl-2-methoxyethenyl)-3-isocyanopyridines with Excess Organolithiums
  作者：Kazuhiro Kobayashi、Taketoshi Kozuki、Shuhei Fukamachi、Hisatoshi Konishi

  DOI：10.1002/hlca.201000214

  日期：2010.10

  AbstractA convenient method for the synthesis of 2,4,8‐trisubstituted 1,7‐naphthyridines 6 by the reaction of (E)‐4‐(1‐aryl‐2‐methoxyethenyl)‐3‐isocyanopyridines 4, which could be easily prepared from commercially available 3‐aminopyridine via aroylation of lithium (4‐lithiopyridin‐3‐yl)pivalamide with N‐methoxy‐N‐methylbenzamides, with excess organolithiums has been developed.