4-Hydroxybuttersaeure-isopropylester | 6092-92-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Hydroxybuttersaeure-isopropylester
• 英文别名: Isopropyl 4-hydroxybutanoate；propan-2-yl 4-hydroxybutanoate
• CAS: 6092-92-8
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: YBELLQGHZRJPKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三(4-硝基苯基)磷酸酯 、 4-Hydroxybuttersaeure-isopropylester 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  [EN] CYCLIC PHOSPHATE SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  [FR] COMPOSÉS NUCLÉOSIDES CYCLIQUES À SUBSTITUTION PHOSPHATE ET LEURS PROCÉDÉS D'UTILISATION POUR LE TRAITEMENT DE MALADIES VIRALES

  摘要：

  本发明涉及具有式（I）的环磷酸酯取代核苷化合物及其药用可接受的盐，其中A、B、R1、R2、R3、Q和V如本文所定义。本发明还涉及包含环磷酸酯取代核苷化合物的组合物，以及使用环磷酸酯取代核苷化合物治疗或预防患者HCV感染的方法。

  公开号：

  WO2017223012A1
• 作为产物：
  描述：

  di-i-propyl 2-oxo-pentandioate 在 baker's yeast 作用下， 以14%的产率得到4-Hydroxybuttersaeure-isopropylester
  参考文献：
  名称：

  Enantiomerically pure tetrahydro-5-oxo-2-furancarboxylic esters from dialkyl 2-oxoglutarates

  摘要：

  Enantiomerically pure tetrahydro-5-oxo-2-furancarboxylic esters can be prepared either by enzymatic resolution of the racemic gamma-lactones themselves or by bioreduction with baker's yeast of dialkyl 2-oxoglutarates and subsequent cyclization of the resulting dialkyl 2-hydroxyglutarates. The best results were obtained by the former route, by which the desired compounds were isolated in high enantiomeric excess. Bioreductions were less satisfactory. In fact the hydroxyester intermediates were initially formed as racemic mixtures and their final enantiomeric enrichment was reached by asymmetric destruction, occurring in the bioreaction medium, however at the same time large amounts of alkyl 4-hydroxybutanoates were formed as side products. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00286-4

文献信息

• [EN] THE RING OPENING OF LACTONES AND LACTAMS<br/>[FR] OUVERTURE DE CYCLE DE LACTONES ET DE LACTAMES
  申请人：NOVARTIS AG

  公开号：WO2011019789A1

  公开（公告）日：2011-02-17

  The present invention provides a novel process for opening a lactone and/or a lactam ring. More particularly, the present invention provides a process that employs a novel catalyst in the opening of a lactone ring and/or a lactam ring. Additionally, the present invention also provides a novel deprotection process of any protecting group present in either the lactone ring-containing and/or lactam ring-containing compound and/or in the ring-opened product thereof.

  本发明提供了一种新颖的打开内酯和/或内酰胺环的方法。更具体地说，本发明提供了一种在打开内酯环和/或内酰胺环中使用新型催化剂的方法。此外，本发明还提供了一种新颖的去保护过程，用于去除内含内酯环和/或内酰胺环的化合物中任何保护基，以及去除其环打开产物中的保护基。
• 3',5'-CYCLIC PHOSPHATE PRODRUGS FOR HCV INFECTION
  申请人：Idenix Pharmaceuticals Inc.

  公开号：US20130315867A1

  公开（公告）日：2013-11-28

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗黄病毒科感染，包括HCV感染的化合物、组合物和方法。在某些实施例中，披露了核苷类衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• Substituted Tetrahydropyrrolopyrazine Compounds
  申请人：REICH Melanie

  公开号：US20120058999A1

  公开（公告）日：2012-03-08

  Tetrahydropyrrolopyrazine compounds, methods for their preparation, pharmaceutical compositions containing such compounds, and a method of using such compounds for the treatment of pain and other conditions mediated at least partially by Bradykinin 1 receptors (B1R).

  四氢吡咯吡嗪化合物，其制备方法，含有这种化合物的药物组合物，以及利用这种化合物治疗至少部分由激肽酶1受体（B1R）介导的疼痛和其他病症的方法。
• [EN] SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE DERIVATIVES<br/>[FR] DÉRIVÉS DE TÉTRAHYDROPYRROLOPYRAZINES SUBSTITUÉES
  申请人：GRUENENTHAL GMBH

  公开号：WO2012028331A1

  公开（公告）日：2012-03-08

  The present invention relates to tetrahydropyrrolopyrazines, methods for the preparation thereof, medicaments containing these compounds and compounds for the use of treating, amongst other things, pain.

  这项发明涉及四氢吡咯吡嘧啶，其制备方法，含有这些化合物的药物以及用于治疗疼痛等疾病的化合物。
• 3-Arylisothiazoles and their use as herbicides
  申请人：——

  公开号：US20040023807A1

  公开（公告）日：2004-02-05

  3-Arylisothiazoles of the formula I 1 in which the variables X, Q, R 1 , R 2 , R 3 , R 4 , R 5 are as defined in claim 1, and salts thereof, and their use for controlling harmful plants, are described.

  描述了具有以下公式I1的3-芳基异噻唑，其中变量X、Q、R1、R2、R3、R4、R5如权利要求1中定义的，并且其盐及其用于控制有害植物的用途。