1-pyrenebutyric acid N-hydroxysuccinimide ester | 192432-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 1-pyrenebutyric acid N-hydroxysuccinimide ester
• 英文别名: succinimido 1-pyrenebutyrate；1-(4-(Pyren-1-yl)butanoyl)pyrrolidine-2,5-dione；1-(4-pyren-1-ylbutanoyl)pyrrolidine-2,5-dione
• CAS: 192432-85-2
• 化学式: C₂₄H₁₉NO₃
• 分子量: 369.42
• InChiKey: XYJNTRZBYNRQEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-氨基苯硼酸 、 1-pyrenebutyric acid N-hydroxysuccinimide ester 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 [3-(4-Pyren-1-ylbutanoylamino)phenyl]boronic acid
  参考文献：
  名称：

  Fluorescence detection of ATP based on the ATP-mediated aggregation of pyrene-appended boronic acid on a polycationElectronic supplementary information (ESI) available: experimental details. See http://www.rsc.org/suppdata/cc/b4/b400644e/

  摘要：

  利用聚阳离子上连接的硼酸衍生的芘在ATP介导的聚集过程中的机制，研发出一种新型的ATP荧光传感体系。

  DOI：

  10.1039/b400644e

文献信息

• Characterization of daptomycin oligomerization with perylene excimer fluorescence: Stoichiometric binding of phosphatidylglycerol triggers oligomer formation
  作者：Jawad K. Muraih、Jesse Harris、Scott D. Taylor、Michael Palmer

  DOI：10.1016/j.bbamem.2011.10.027

  日期：2012.3

  phosphatidylglycerol in the target membrane. Daptomycin has been shown to form oligomers on liposome membranes. We here use perylene excimer fluorescence to further characterize the membrane-associated oligomer. To this end, the N-terminal fatty acyl chain was replaced with perylene-butanoic acid. The perylene derivative retains one third of the antibacterial activity of native daptomycin. On liposomes containing phosphatidylcholine

  达托霉素是一种脂肽抗生素，可与细菌细胞膜结合并使其去极化。它的抗菌活性需要钙，并且与靶膜中的磷脂酰甘油含量有关。已经证明达托霉素在脂质体膜上形成寡聚物。我们在这里使用per准分子荧光来进一步表征膜相关的低聚物。为此，将N-末端脂肪酰基链替换为per-丁酸。ylene衍生物保留了天然达托霉素的三分之一的抗菌活性。在含有磷脂酰胆碱和磷脂酰甘油的脂质体上，以及在枯草芽孢杆菌细胞上，per标记的达托霉素形成受激准分子，这表明相邻低聚物亚基的N末端酰基链彼此直接接触。在脂质比塞勒系统中，可以用化学计量的磷脂酰甘油滴定低聚物的形成。因此，达托霉素与单分子磷脂酰甘油的相互作用足以触发达托霉素寡聚。
• High-Density Noncovalent Functionalization of DNA by Electrostatic Interactions
  作者：Wei Chen、Jennifer Y. Gerasimov、Pei Zhao、Kai Liu、Andreas Herrmann

  DOI：10.1021/jacs.5b05432

  日期：2015.10.14

  Preserving DNA hybridization in organic solvents could someday serve to significantly extend the applicability of DNA-based technologies. Here, we present a method that can be used to solubilize double-stranded DNA at high concentrations in organic media. This method requires first precipitating a DNA molecule from the aqueous environment with an anilinium derivative and subsequently exchanging this moiety with an amine-containing surfactant in organic solvent. We demonstrate that this method yields complete exchange of the surfactant and allows for the modification of DNA with hydrophobic primary, secondary, and tertiary alkylamines and ordered functional lcsystems. Using this approach, we fabricate a multichromophoric light harvesting system that would be unattainable by traditional methods. Additionally, this method makes it possible to use small, hydrophilic molecules to solubilize DNA in organic solvents, which reduces the shielding around the macromolecule more accessible for further chemical modification. We believe that this approach will prove beneficial in expanding the scope of DNA-based nano- and biotechnologies. DNA and makes the tremendously
• TELSER, JOSHUA;CRUICKSHANK, KENNETH A.;MORRISON, LARRY E.;NETZEL, THOMAS +, J. AMER. CHEM. SOC., 111,(1989) N8, C. 6966-6976
  作者：TELSER, JOSHUA、CRUICKSHANK, KENNETH A.、MORRISON, LARRY E.、NETZEL, THOMAS +

  DOI：——

  日期：——