N-ornithyl-L-taurine | 98349-67-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-ornithyl-L-taurine
• 英文别名: L-ornithyltaurine；Ornithyltaurine；2-[[(2S)-2,5-diaminopentanoyl]amino]ethanesulfonic acid
• CAS: 98349-67-8
• 化学式: C₇H₁₇N₃O₄S
• 分子量: 239.296
• InChiKey: JALOHEZOHSEEMS-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  144
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2S)-2,5-双[(叔丁氧羰基)氨基]戊酸 在 盐酸 、 三乙胺 、 sodium hydroxide 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 6.0h， 生成 N-ornithyl-L-taurine
  参考文献：
  名称：

  一种咸味肽鸟氨酰牛磺酸的合成方法

  摘要：

  本发明公开了一种咸味肽鸟氨酰牛磺酸的合成方法，属于多肽合成技术领域。该合成方法为：双氨基保护的鸟氨酸与氯甲酸乙酯或氯甲酸异丁酯在低温碱性条件下反应，生成活泼酯，再与牛磺酸反应得到保护的鸟氨酰牛磺酸，最后脱保护得到咸味肽鸟氨酰牛磺酸。本发明合成步骤短，原料廉价易得，副产物少，质量稳定可控，收率高，扩大其应用研究及规模化提供新的解决思路。且得到的产品可直接用作咸味剂。

  公开号：

  CN108794356A

文献信息

• Age Inhibitors
  申请人：Potier Pierre

  公开号：US20080249030A1

  公开（公告）日：2008-10-09

  The invention relates to a compound having general formula I, wherein: X represents CH 2 , C═O, C═S or CHOH, X represents CH 2 , C═O, C═S or CHOH, R 1 represents an amino acid which is optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF 3 groups and n=0.1 or 2, or X represents CH 2 , C═O, C═S, CHOH, R 1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF 3 groups and n=0 or 1, or XR 1 represent PO 3 H or SO 3 H and n=0.1 or 2; R 2 represents H, XR 1 , an alkyl group at C 1 -C 6 , an aralkyl group at C 1 -C 6 or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH 2 , a carboxylic group COOH, one or more halogen atoms, preferably fluorine, or one or more CF 3 groups; or the pharmaceutically-acceptable addition salts, isomers, enantiomers and diastereoisomers of said compound, mixtures thereof, and pharmaceutical or cosmetic compositions comprising same and the use thereof as an AGE-inhibitor drug that traps reactive carbonyl compounds.

  该发明涉及一种具有一般式I的化合物，其中：X代表CH2、C═O、C═S或CHOH，X代表CH2、C═O、C═S或CHOH，R1代表一种氨基酸，该氨基酸可以选择性地被一个或多个卤素原子（优选为氟）或一个或多个CF3基团取代，n=0.1或2，或者X代表CH2、C═O、C═S、CHOH，R1代表含有两个氨基酸的肽，每个氨基酸可以选择性地被一个或多个卤素原子（优选为氟）或一个或多个CF3基团取代，n=0或1，或者XR1代表PO3H或SO3H，n=0.1或2；R2代表H、XR1、C1-C6的烷基、C1-C6的芳基烷基或芳基，其中烷基、芳基烷基和芳基可以被氨基NH2、羧基COOH、一个或多个卤素原子（优选为氟）或一个或多个CF3基团取代；或者所述化合物的药学上可接受的加合盐、异构体、对映体和二对映异构体，其混合物，以及包含其的制药或化妆品组合物及其作为捕捉反应性羰基化合物的AGE抑制剂药物的用途。
• Convenient Synthesis of <scp>l</scp>-Ornithyltaurine·HCl and the Effect on Saltiness in a Food Material
  作者：Kozo Nakamura、Rie Kuramitu、Shirou Kataoka、Daisuke Segawa、Kouji Tahara、Masahiro Tamura、Hideo Okai

  DOI：10.1021/jf950711u

  日期：1996.1.1

  A new convenient synthesis of a salty peptide, ornithyltaurine (Orn-Tau), was designed. Compared with a conventional synthesis, the process was shortened by two steps and the purification was made much easier in the new one. Consequently, Orn-Tau was easily obtained and subjected to a further series of experiments. The product produced a good saltiness without Na+ in the presence of HCl, and the saltiness became stronger as the amount of added HCl increased. The best quality of saltiness was obtained by adding 1.2 equiv of HCl to the Orn-Tau solutions. The Orn-Tau . 1.2HCl was equally salty to NaCl on a molar basis and also had an enhancing effect on saltiness of NaCl. The intake of Na+ could be cut by 95% in a model system and by 50% in a food material (soy sauce) by using Orn-Tau . 1.2HCl, which have the most excellent saltiness and Naf dietary effect of our NaCl substitutes at the present time.
• AGNES, GIOVANNI;ALTAMURA, MARIA
  作者：AGNES, GIOVANNI、ALTAMURA, MARIA

  DOI：——

  日期：——
• SPECIFIC EATABLE TASTE MODIFIERS
  申请人：BIORESEARCH, INC.

  公开号：EP0661932A1

  公开（公告）日：1995-07-12
• EP0661932A4
  申请人：——

  公开号：EP0661932A4

  公开（公告）日：1996-06-05