NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS
申请人:MetCalf, III Chester A.
公开号:US20100184649A1
公开(公告)日:2010-07-22
The present invention relates to novel lipopeptide compounds, pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The compounds of the invention are particularly useful against a variety of bacteria, including resistant strains. The compounds are useful as antibacterial agents against
Clostridium difficile.
[EN] NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS<br/>[FR] NOUVEAUX AGENTS ANTIBACTÉRIENS POUR LE TRAITEMENT D'INFECTIONS GRAM POSITIVES
申请人:CUBIST PHARM INC
公开号:WO2010075215A1
公开(公告)日:2010-07-01
The present invention relates to novel lipopeptide compounds, pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The compounds of the invention are particularly useful against a variety of bacteria, including resistant strains. The compounds are useful as antibacterial agents against Clostridium difficile.
A compound represented by the general formula:
or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C
6-14
aryl group or the like, L is —NR
e
CO— or the like (wherein R
e
is a hydrogen atom or the like), Ring B is a C
6-14
aryl group or the like, X is a C
1-3
alkylene group or the like, Y is a single bond or the like, Z is a C
1-3
alkylene group or the like, R
1
and R
2
are each independently a hydrogen atom or the like, and R
3
, R
4
, R
5
and R
6
are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
Antibacterial agents for the treatment of gram positive infections
申请人:Metcalf, III Chester A.
公开号:US08507647B2
公开(公告)日:2013-08-13
The present invention relates to novel lipopeptide compounds, pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The compounds of the invention are particularly useful against a variety of bacteria, including resistant strains. The compounds are useful as antibacterial agents against Clostridium difficile.
Indole and indoline derivatives of the formula:
wherein indicates a double bond or a single bond between carbon atoms, R1 represents an alkyl group containing 1 to 6 carbon atoms (which may be substituted by one or more than one of the same type of substituents selected from the hydroxy group, alkenyl groups containing 2 to 5 carbon atoms, and alkanoyloxy groups containing 2 to 7 carbon atoms) or a hydrogen atom, and one of the symbols R2 represents an alkyl group containing 6 to 24 carbon atoms and the other symbol R2 represents an alkyl group containing 1 to 24 carbon atoms, or a hydrogen atom, and R3 reptesents an alkyl group containing 1 to 6 carbon atoms or a hydrogen atom, are new compounds possessing useful pharmacological properties. They are of use in the treatment of diabetes mellitus, hyperlipoproteinaemic states, of atherosclerosis, and of associated disorders. Pharmaceutical compositions containing the compounds are described and so are numerous processes for oreparing the compounds.