3-<<2-<2,5-bis(benzyloxy)benzamido>ethyl>amino>-1-phenoxypropan-2-ol | 53673-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-<<2-<2,5-bis(benzyloxy)benzamido>ethyl>amino>-1-phenoxypropan-2-ol
• 英文别名: 1-Phenoxy-3-beta-(2,5-dibenzyloxybenzamido)ethylamino-2-propanol；N-[2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl]-2,5-bis(phenylmethoxy)benzamide
• CAS: 53673-62-4
• 化学式: C₃₂H₃₄N₂O₅
• 分子量: 526.632
• InChiKey: GNEQEQPUJLKTBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  89
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-<<2-<2,5-bis(benzyloxy)benzamido>ethyl>amino>-1-phenoxypropan-2-ol 在 palladium on activated charcoal 氢气 作用下， 以 溶剂黄146 为溶剂， 以42%的产率得到3-<<2-(2,5-dihydroxybenzamido)ethyl>amino>-1-phenoxypropan-2-ol oxalate
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents. 22. 1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols

  摘要：

  The synthesis of a series of 1-phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols is described. Many of the compounds are more potent than propanolol as beta blockers, while having cardioselectivity comparable to that of practolol, when given intravenously to anesthetized cats. The structure-activity relationships shown by this series of compounds provide further evidence that the addition of substituents to the alkylamino moeity of a beta blocker can confer cardioselectivity and that amidic substituents are remarkably effective.

  DOI：

  10.1021/jm00353a004
• 作为产物：
  描述：

  苯基缩水甘油醚 、 2-[2,5-bis-(benzyloxy)benzoyl-amino]ethylamine 在 sodium hydroxide 作用下， 以 丙醇 为溶剂， 反应 18.0h， 生成 3-<<2-<2,5-bis(benzyloxy)benzamido>ethyl>amino>-1-phenoxypropan-2-ol
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents. 22. 1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols

  摘要：

  The synthesis of a series of 1-phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols is described. Many of the compounds are more potent than propanolol as beta blockers, while having cardioselectivity comparable to that of practolol, when given intravenously to anesthetized cats. The structure-activity relationships shown by this series of compounds provide further evidence that the addition of substituents to the alkylamino moeity of a beta blocker can confer cardioselectivity and that amidic substituents are remarkably effective.

  DOI：

  10.1021/jm00353a004

文献信息

• Pharmaceutical compositions and uses of alkanolamine derivatives
  申请人：Imperial Chemical Industries Limited

  公开号：US04131685A1

  公开（公告）日：1978-12-26

  1-Aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-phenoxy-3-.beta.-isobutyramidoethylamino-2-propanol.

  1-芳氧基-3-酰胺基烷基氨基-2-丙醇衍生物，其制造过程，含有它们的制药组合物以及在治疗心脏疾病中使用它们的方法。这些化合物具有β-肾上腺素能阻滞活性，其中一些还具有心脏兴奋剂活性。其中一种化合物是1-苯氧基-3-β-异丁酰胺乙基氨基-2-丙醇。
• US4131685A
  申请人：——

  公开号：US4131685A

  公开（公告）日：1978-12-26
• US4167581A
  申请人：——

  公开号：US4167581A

  公开（公告）日：1979-09-11
• .beta.-Adrenergic blocking agents. 22. 1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols
  作者：M. S. Large、L. H. Smith

  DOI：10.1021/jm00353a004

  日期：1982.11

  The synthesis of a series of 1-phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols is described. Many of the compounds are more potent than propanolol as beta blockers, while having cardioselectivity comparable to that of practolol, when given intravenously to anesthetized cats. The structure-activity relationships shown by this series of compounds provide further evidence that the addition of substituents to the alkylamino moeity of a beta blocker can confer cardioselectivity and that amidic substituents are remarkably effective.