tert-butyl 1,3-dihydroxy-3-methylbutan-2-ylcarbamate | 1353743-61-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl 1,3-dihydroxy-3-methylbutan-2-ylcarbamate
• 英文别名: Tert-butyl (1,3-dihydroxy-3-methylbutan-2-YL)carbamate；tert-butyl N-(1,3-dihydroxy-3-methylbutan-2-yl)carbamate
• CAS: 1353743-61-9
• 化学式: C₁₀H₂₁NO₄
• 分子量: 219.281
• InChiKey: ZCNIHVVSMKRMGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-羟基氨基甲酸叔丁酯 在 potassium osmate(VI) dihydrate 、 水 、 三乙胺 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 生成 tert-butyl 1,3-dihydroxy-3-methylbutan-2-ylcarbamate
  参考文献：
  名称：

  N-（4-甲苯磺酰氧基）氨基甲酸酯对烯烃的V催化邻位氧化

  摘要：

  在一系列单，二和三取代烯烃的分子间催化的氧化胺化反应中，基于一系列常见胺保护基的N-（4-甲苯磺酰氧基）氨基甲酸酯用作预制的氮源。该反应以低的催化剂负载量和良好的收率进行，并且对于不对称取代的烯烃提供高的区域选择性。

  DOI：

  10.1021/jo301372y

文献信息

• Regioselective Base-Free Intermolecular Aminohydroxylations of Hindered and Functionalized Alkenes
  作者：Zhiwei Ma、Bradley C. Naylor、Brad M. Loertscher、Danny D. Hafen、Jasmine M. Li、Steven L. Castle

  DOI：10.1021/jo202375a

  日期：2012.1.20

  Regioselective base-free intermolecular aminohydroxylations of functionalized trisubstituted and 1,1-disubstituted alkenes employing benzoyloxycarbamate 3a and catalytic OsO4 are described. In all cases, the more substituted alcohol isomer is favored. Sluggish reactions could be promoted by gentle heating, the use of amine ligands, or increased catalyst loadings. A competitive rearrangement was observed with a secondary allylic alcohol substrate. The adducts serve as useful precursors to dehydroamino acids.
• N-1 BRANCHED ALKYL ETHER SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20210323962A1

  公开（公告）日：2021-10-21

  Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N−1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.