(1-Methyl-allyloxy)-acetic acid butyl ester | 85428-61-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1-Methyl-allyloxy)-acetic acid butyl ester
• 英文别名: Butyl 2-but-3-en-2-yloxyacetate
• CAS: 85428-61-1
• 化学式: C₁₀H₁₈O₃
• 分子量: 186.251
• InChiKey: CSOBMYSMZNWLAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  butyl diazoacetate 、 3-丁烯-2-醇 、 二聚醋酸铑 以68%的产率得到
  参考文献：
  名称：

  NOELS, A. F.;DEMONCEAU, A.;PETINIOT, N.;HUBERT, A. J.;TEYSSIE, PH., TETRAHEDRON, 1982, 38, N 17, 2733-2739

  摘要：

  DOI：

文献信息

• [EN] FUSED AMINODIHYDROTHIAZINE DERIVATIVES<br/>[FR] DÉRIVÉS D'AMINODIHYDROTHIAZINE FUSIONNÉS
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2012093148A1

  公开（公告）日：2012-07-12

  The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein R is hydrogen or C1 -6 alkyl,optionally substituted by one to five halogen atoms; n is 0,1,2 or 3; Ar is phenyl or a 5-or 6-membered heteroaromatic group containing 1,2 or 3 N atoms,which Ar is optionally substituted by one to three substituents selected from hal, hydroxyl,-CN,C1-6alkyl,C2-3alkenyl,C2-3alkynyl,C-6alkoxy,C3-6cycloalkoxy and pyrazine,where C1-6alkyl and C1-6alkoxy are optionally substituted by one to three halogen atoms; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease1 caused by Aβ and typified by Alzheimer-type dementia.

  本发明涉及一种公式（I）的融合氨基二氢噻唑衍生物：其中R是氢或C1-6烷基，可选地被一个至五个卤素原子取代；n是0、1、2或3；Ar是苯基或含1、2或3个N原子的5或6元杂芳基族，该Ar可选地被一个至三个选自卤素、羟基、-CN、C1-6烷基、C2-3烯基、C2-3炔基、C-6烷氧基、C3-6环烷氧基和吡嗪的取代基取代，其中C1-6烷基和C1-6烷氧基可选地被一个至三个卤素原子取代；以及药用可接受的盐；该化合物具有Aβ生成抑制效果或BACE1抑制效果，并且用作预防或治疗由Aβ引起的神经退行性疾病1的预防或治疗剂，该疾病以阿尔茨海默症型痴呆为典型。
• Transition-metal-catalyzed reaction of diazocompounds, efficient synthesis of functionalized ethers by carbene insertion into the hydroxylic bond of alcohols
  作者：A.F. Noels、A. Demonceau、N. Petiniot、A.J. Hubert、Ph. Teyssié

  DOI：10.1016/0040-4020(82)80031-8

  日期：——

  An Efficient catalytic synthesis of unsaturated ethers by carbene insertion (with diazoesters as carbene precursors) into the OH bond of unsaturated alcohols is reported. The regioselectivity for the OH insertion is high. However, depending on the catalyst counter-ions and the diazoester alkoxy group, addition to the unsaturated centre can be promoted to some extent, yielding then cyclopropyl and cyclopropenyl

  据报道，通过将卡宾（以重氮酸酯作为卡宾的前体）插入不饱和醇的OH键，可以有效地催化合成不饱和醚。OH插入的区域选择性高。然而，取决于催化剂的抗衡离子和重氮酯烷氧基，可以在一定程度上促进向不饱和中心的加成，然后得到环丙基和环丙烯基甲醇。讨论了反应的机理。
• FUSED AMINODIHYDROTHIAZINE DERIVATIVES
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2661267A1

  公开（公告）日：2013-11-13
• NOELS, A. F.;DEMONCEAU, A.;PETINIOT, N.;HUBERT, A. J.;TEYSSIE, PH., TETRAHEDRON, 1982, 38, N 17, 2733-2739
  作者：NOELS, A. F.、DEMONCEAU, A.、PETINIOT, N.、HUBERT, A. J.、TEYSSIE, PH.

  DOI：——

  日期：——