8-ethylthio-3H-imidazo[4,5-g]quinazoline | 1262431-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-ethylthio-3H-imidazo[4,5-g]quinazoline
• 英文别名: 8-ethylsulfanyl-1H-imidazo[4,5-g]quinazoline
• CAS: 1262431-75-3
• 化学式: C₁₁H₁₀N₄S
• 分子量: 230.293
• InChiKey: RQHUNLPKXHJUCA-UHFFFAOYSA-N

物化性质

• 沸点：
  549.2±30.0 °C(Predicted)
• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-ethylthio-3H-imidazo[4,5-g]quinazoline 在 N,O-双三甲硅基乙酰胺 、 对甲苯磺酸 作用下， 以 氯苯 、 乙腈 为溶剂， 反应 4.83h， 生成 8-ethylthio-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-3H-imidazo[4,5-g]quinazoline
  参考文献：
  名称：

  The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides

  摘要：

  The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.

  DOI：

  10.1021/ol102915f
• 作为产物：
  描述：

  8-mercaptoimidazo<4,5-g>quinazoline 、 碘乙烷 、 potassium hydroxide 以 甲醇 、 水 为溶剂， 反应 0.33h， 以60%的产率得到8-ethylthio-3H-imidazo[4,5-g]quinazoline
  参考文献：
  名称：

  The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides

  摘要：

  The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.

  DOI：

  10.1021/ol102915f

文献信息

• The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides
  作者：Armando R. Hernández、Eric T. Kool

  DOI：10.1021/ol102915f

  日期：2011.2.18

  The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.