2'-deoxycytidine-5'-tetraphosphate | 116664-99-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 2'-deoxycytidine-5'-tetraphosphate
• 英文别名: [[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate
• CAS: 116664-99-4
• 化学式: C₉H₁₇N₃O₁₆P₄
• 分子量: 547.14
• InChiKey: HCMGQTBXNMTYAB-SHYZEUOFSA-N

物化性质

• 沸点：
  889.7±75.0 °C(Predicted)
• 密度：
  2.52±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.7
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  295
• 氢给体数：
  7
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  2'-脱氧胞嘧啶核苷 在 磷酸三甲酯 、 三正丁胺 、 tris[tributylammonium] triphosphate 、 三氯氧磷 作用下， 以 乙腈 为溶剂， 生成 2'-deoxycytidine-5'-tetraphosphate
  参考文献：
  名称：

  A new, facile, and protection-free one-pot chemical synthesis of 2′-deoxynucleoside-5′-tetraphosphates

  摘要：

  A new straight forward, reliable, and an efficient method for the chemical synthesis of 2'-deoxynucleoside-5'-tetraphosphate is reported. The present 'one-pot, three step' synthetic strategy involves the monophosphorylation of nucleoside followed by reaction with tris-(tri-n-butylammonium) triphosphate and hydrolysis of the putative cyclic tetrametaphosphate intermediate to provide the corresponding 2'-deoxynucleoside-5'-tetraphosphate in moderate yield with high purity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.08.071

文献信息

• Composition and method for inhibiting platelet aggregation
  申请人：——

  公开号：US20040220133A1

  公开（公告）日：2004-11-04

  This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis. The method comprises administering to a subject a pharmaceutical composition comprising a therapeutic effective amount of P2Y 12 receptor antagonist compound, wherein said amount is effective to bind the P2Y 12 receptors on platelets and inhibit ADP-induced platelet aggregation. The P2Y 12 receptor antagonist compounds useful for this invention include mononucleoside 5′-monophosphates, mononucleoside polyphosphates, and dinucleoside polyphosphates of general Formula I, or salts thereof. The present invention also provides novel compounds of mononucleoside 5′-monophosphates, mononucleoside polyphosphates, and dinucleoside polyphosphates. The present invention further provides pharmaceutical formulations comprising mononucleoside 5′-monophosphates, mononucleoside polyphosphates, or dinucleoside polyphosphates.

  本发明涉及一种预防或治疗与血小板聚集相关的疾病或症状的方法。该方法还涉及一种治疗血栓形成的方法。该方法包括向受试者施用含有治疗有效量的P2Y12受体拮抗剂化合物的制剂，其中该量足以结合血小板上的P2Y12受体并抑制ADP诱导的血小板聚集。本发明中有用于此的P2Y12受体拮抗剂化合物包括通式I的单核苷酸5'-单磷酸盐、单核苷酸多磷酸盐和二核苷酸多磷酸盐。本发明还提供了单核苷酸5'-单磷酸盐、单核苷酸多磷酸盐和二核苷酸多磷酸盐的新化合物。本发明还提供了含有单核苷酸5'-单磷酸盐、单核苷酸多磷酸盐或二核苷酸多磷酸盐的制药配方。
• LARGE STOKES SHIFT DYES
  申请人：Life Technologies Corporation

  公开号：EP2396318A2

  公开（公告）日：2011-12-21
• Use of UTP for the diagnosis of stenoses and other conditions of restricted blood flow
  申请人：Rosenmeier Jaya Brigitte

  公开号：US20110085977A1

  公开（公告）日：2011-04-14

  The present invention relates to methods for determining whether blood flow is restricted in a blood vessel of an individual suspected of compromised blood flow in the vessel, the method comprising the steps of delivering UTP, a derivative thereof, or a salt thereof to the vessel, assessing blood flow quantitatively in the vessel by obtaining a value that correlates to blood flow in said vessel, comparing the obtained value with a reference value, and determining whether the individual has compromised blood flow based on the results of the comparison. The invention also provides for methods of diagnosing atherosclerotic and ischemic heart diseases using UTP, a derivative thereof, or a salt thereof, as well as methods for inducing maximal hyperemia for diagnostic purposes.
• COMPOSITIONS AND METHODS FOR IMPROVING THE THERMAL STABILITY OF NUCLEIC ACID AMPLIFICATION REAGENTS
  申请人：Roche Molecular Systems, Inc.

  公开号：US20180363044A1

  公开（公告）日：2018-12-20

  The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises nucleoside polyphosphates having four or more phosphates. The present invention also provides for methods for using the nucleoside polyphosphates having four or more phosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.
• METHODS OF SYNTHESIZING OLIGONUCLEOTIDES USING TETHERED NUCLEOTIDES
  申请人：Twist Bioscience Corporation

  公开号：US20220145289A1

  公开（公告）日：2022-05-12

  Disclosed herein are methods and compositions comprising a polymerase and a phosphorylated nucleoside, wherein the polymerase and the nucleoside are covalently linked by a cleavable linker at the terminal phosphate group. Further disclosed herein are enzymatic polynucleotide synthesis using polymerase and nucleotide conjugation strategies.