α-Methylphenylalanineamide | 117466-13-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-Methylphenylalanineamide
• 英文别名: 2-Amino-2-methyl-3-phenylpropanamide
• CAS: 117466-13-4
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: LEBDCRNSLNAHHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-Methylphenylalanineamide 生成 2-甲基-L-苯丙氨酸一水物
  参考文献：
  名称：

  Enzymatic resolution of α,α-disubstituted α-amino acid esters and amides

  摘要：

  The scope and limitations of the enzymatic resolution of alpha,alpha-disubstituted alpha-amino acid amides by an amino acid amidase from Mycobacterium neoaurum and of the corresponding ethyl esters with Pig liver esterase (PLE) have been studied. Moderate enantiomeric excesses were obtained with PLE, with only a narrow substrate specificity. Mycobacterium neoaurum on the contrary yields a broad range of S-alpha,alpha-disubstituted alpha-amino acids 1 and the corresponding R-amides 2.

  DOI：

  10.1016/s0957-4166(00)80217-7
• 作为产物：
  描述：

  2-氨基-2-甲基-3-苯基丙腈 生成 α-Methylphenylalanineamide
  参考文献：
  名称：

  EHNOMIYA, TAKUDZU;SIRAISI, YASUSI

  摘要：

  DOI：

文献信息

• MOLECULES HAVEING PESTICIDAL UTILIY AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO
  申请人：Dow AgroSciences LLC

  公开号：US20180098541A1

  公开（公告）日：2018-04-12

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫有用的杀虫性的分子领域，用于生产这种分子的过程，用于这种过程的中间体，含有这种分子的杀虫组合物，以及使用这种杀虫组合物对这些害虫进行处理的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。
• Synthesis of dipeptides containing α-substituted amino acids; their use as chiral ligands in Lewis-acid-catalyzed reactions
  作者：Bernard Kaptein、Vania Monaco、Quirinus B. Broxterman、Hans E. Schoemaker、Johan Kamphuis

  DOI：10.1002/recl.19951140417

  日期：——

  Ochrobactrum anthropi NCIMB 40321, was used in the synthesis of dipeptides containing α-substituted amino acids. The 2-hydroxynaphthalene-1-carboxaldehyde Schiff bases of the dipeptides (1 and 2) were tested as Ti(IV) and Al(III) complexes in asymmetric Lewis-acid-catalyzed reactions. Only the Al(III) complex of 2 showed moderate enantioselectivity in the cyanation reaction of benzaldehyde with TMS-CN.

  L-α-甲基苯基丙氨酸，是通过用拟南芥（Ochrobactrum anthropi NCIMB 40321）的酰胺酶酶解相应的外消旋酰胺而制得的，用于合成含α-取代氨基酸的二肽。在不对称路易斯酸催化的反应中，对二肽（1和2）的2-羟基萘-1-甲醛Schiff碱作为Ti（IV）和Al（III）配合物进行了测试。仅在Al（III）络合物的2显示中等的对映选择性的苯甲醛与TMS-CN氰化反应。
• Synthesis of α,α-disubstituted α-amino acid amides by phase-transfer catalyzed alkylation
  作者：Bernard Kaptein、Wilhelmus H.J. Boesten、Quirinus B. Broxterman、Hans E. Schoemaker、Johan Kamphuis

  DOI：10.1016/s0040-4039(00)61112-7

  日期：1992.9

  α,α-Disubstituted α-amino acid amides were prepared in 17–86% chemical yield by the phase-transfer catalyzed alkylation of N-benzylidene α-H amino acid amides, followed by weak acidic hydrolysis of the Schiff bases.

  通过相转移催化N-亚苄基α-H氨基酸酰胺的烷基化反应，然后对席夫碱进行弱酸性水解，可以制备出化学产率为17-86％的α，α-二取代的α-氨基酸酰胺。
• (S)-2H-2-oxo-5,5-dimethyl-4(R)-phenyl-1,3,2-dioxaphosphorinane, a new reagent for the enantiomeric excess determination of unprotected amino acids using 31P NMR
  作者：Ron Hulst、Robert W.J. Zijlstra、N.Koen de Vries、Ben L. Feringa

  DOI：10.1016/0957-4166(94)80081-2

  日期：1994.9

  Diastereomeric amide derivatives of title phosphorinane 2 and unprotected amino acids are easily prepared in aqueous solutions, showing well separated signals in the 31P NMR spectra allowing accurate e.e. determination.

  在水溶液中可以轻松制备标题膦烷2和非保护氨基酸的非对映异构酰胺衍生物，在31 P NMR光谱中显示出分离良好的信号，从而可以准确测定ee。
• c-MET MODULATORS AND METHOD OF USE
  申请人：BANNEN CANNE LYNNE

  公开号：US20070244116A1

  公开（公告）日：2007-10-18

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  本发明提供了用于调节蛋白激酶酶活性，以调节细胞活动，如增殖、分化、程序性细胞死亡、迁移和化学侵袭的化合物。更具体地，本发明提供了喹唑啉和喹啉，这些化合物抑制、调节和/或调节激酶受体，特别是c-Met、KDF、c-Kit、flt-3和flt-4，与上述细胞活动变化相关的信号转导途径，包含这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病况的方法。本发明还提供制备上述化合物的方法和包含这些化合物的组合物。