8-phenyl-octanoic acid benzyloxy-amide | 880089-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-phenyl-octanoic acid benzyloxy-amide
• 英文别名: 8-phenyl-N-phenylmethoxyoctanamide
• CAS: 880089-32-7
• 化学式: C₂₁H₂₇NO₂
• 分子量: 325.451
• InChiKey: WZJNXYHLCBMKRR-UHFFFAOYSA-N

物化性质

• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-phenyl-octanoic acid benzyloxy-amide 在 5% Pd/SiO2 氢气 作用下， 以 甲醇 为溶剂， 反应 120.0h， 以95%的产率得到8-phenyl-octanoic acid hydroxyamide
  参考文献：
  名称：

  [EN] COSMETIC COMPOSITIONS CONTAINING AN HYDROXAMIC ACID COMPOUND OPTIONALLY IN COMBINATION WITH A RETINOID
  [FR] NOUVELLES COMPOSITIONS COSMETIQUES

  摘要：

  公开号：

  WO2006029818A3
• 作为产物：
  描述：

  苄氧基胺盐酸盐 、 8-phenyloctanoyl chloride 以 吡啶 、 二氯甲烷 为溶剂， 以92%的产率得到8-phenyl-octanoic acid benzyloxy-amide
  参考文献：
  名称：

  [EN] COSMETIC COMPOSITIONS CONTAINING AN HYDROXAMIC ACID COMPOUND OPTIONALLY IN COMBINATION WITH A RETINOID
  [FR] NOUVELLES COMPOSITIONS COSMETIQUES

  摘要：

  公开号：

  WO2006029818A3

文献信息

• [EN] NOVEL COSMETIC COMPOSITIONS<br/>[FR] NOUVELLES COMPOSITIONS COSMETIQUES
  申请人：DSM IP ASSETS BV

  公开号：WO2006029818A2

  公开（公告）日：2006-03-23

  The present invention is directed to cosmetic compositions comprising a compound of the general formula (I) wherein L is hydrogen, branched alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, hy­droxyl, OR, HO-(CH2-CH2-O)n, HO-(CH2-O)n, HO-(CH2-CH2-CH2-O)n, HO­(CH2-CH(CH3)-O)n, HO-(CH(CH3)-CH2-O)n, NR4R5, C(O)NR6R7, with R being C1-4-alkyl or C2-18-alkanoyl; n being an integer from 1 to 8; R4, R5, R6 and R7 being independently from each other hydrogen or C1-18-alkyl; R1 is alkylene, alkenylene or alkinylene, optionally substituted with one or more methyl or ethyl groups; R2 is hydrogen or alkyl; and R3 is hydrogen, alkyl, or a cosmetically acceptable cation; and a carrier conventionally used in cosmetic compositions. The compositions preferably comprise additionally a retinoid. The present invention concerns further inter alia the use of such compositions for the treatment or prevention of any symptoms caused by negative developments of the physiological homeostasis of healthy skin, as wel as for the promotion of hair growth and protection from hair loss.
• [EN] COSMETIC COMPOSITIONS CONTAINING AN HYDROXAMIC ACID COMPOUND OPTIONALLY IN COMBINATION WITH A RETINOID<br/>[FR] NOUVELLES COMPOSITIONS COSMETIQUES
  申请人：DSM IP ASSETS BV

  公开号：WO2006029818A3

  公开（公告）日：2006-05-11