2-(3-Phenylpropoxy)-1-(2-pyridyl)ethanol | 115462-41-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3-Phenylpropoxy)-1-(2-pyridyl)ethanol
• 英文别名: 2-(3-Phenylpropoxy)-1-pyridin-2-ylethanol
• CAS: 115462-41-4
• 化学式: C₁₆H₁₉NO₂
• 分子量: 257.332
• InChiKey: DQDXWSVRYUUWBV-UHFFFAOYSA-N

物化性质

• 沸点：
  200-220 °C(Press: 0.5 Torr)
• 密度：
  1.117±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-Phenylpropoxy)-1-(2-pyridyl)ethanol 在 platinum(IV) oxide 盐酸 、 氢氧化钾 、 sodium hydroxide 、 氢气 作用下， 以 乙醇 、 氯仿 为溶剂， 生成 (1S)-2-(3-phenylpropoxy)-1-[(2S)-piperidin-2-yl]ethanol
  参考文献：
  名称：

  Synthesis and .beta.-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols

  摘要：

  A series of erythro- and threo-2-(aryloxy)-1-(2-piperidyl)ethanol derivatives (3) was synthesized from 2-(2-oxiranyl)pyridine for evaluation as beta-antagonists. Most compounds displayed high competitive beta-blocking potency, but they lacked significant beta 1/beta 2 selectivity. The 1-naphthoxy derivative erythro-3b was 17 (beta 1) and 33 (beta 2) times more potent than its open-chain analogue, propranolol. Within the whole series, erythro-3 diastereomers were more potent beta-blockers than the threo-3 isomers, and the potency of the latter seems to be rather insensitive to structural modification. The effect of N-methylation and of interposition of an alkyl chain between the aromatic ring and the side chain, while being detrimental to beta-blocking activity, was less marked than in the classic (aryloxy)propanolamine blockers.

  DOI：

  10.1021/jm00119a011
• 作为产物：
  描述：

  2-乙烯基吡啶 在 N-溴代丁二酰亚胺(NBS) 、 三氟化硼乙醚 、 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 2-(3-Phenylpropoxy)-1-(2-pyridyl)ethanol
  参考文献：
  名称：

  Synthesis and .beta.-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols

  摘要：

  A series of erythro- and threo-2-(aryloxy)-1-(2-piperidyl)ethanol derivatives (3) was synthesized from 2-(2-oxiranyl)pyridine for evaluation as beta-antagonists. Most compounds displayed high competitive beta-blocking potency, but they lacked significant beta 1/beta 2 selectivity. The 1-naphthoxy derivative erythro-3b was 17 (beta 1) and 33 (beta 2) times more potent than its open-chain analogue, propranolol. Within the whole series, erythro-3 diastereomers were more potent beta-blockers than the threo-3 isomers, and the potency of the latter seems to be rather insensitive to structural modification. The effect of N-methylation and of interposition of an alkyl chain between the aromatic ring and the side chain, while being detrimental to beta-blocking activity, was less marked than in the classic (aryloxy)propanolamine blockers.

  DOI：

  10.1021/jm00119a011

文献信息

• Syntheis of 2-aryloxy- and 2-arylalkoxy-1-(2-piperidyl)ethanols
  作者：David Mauleón、M. Dolors Pujol、Cristina Minguillón、Jaume Miquel

  DOI：10.1002/jhet.5570260331

  日期：1989.5

  The preparation and separation of diastereomeric pairs of a series of 2-aryloxy- and 2-arylalkoxy-1-(2-piperidyl)ethanols is reported. The erythro aminoalcohols were converted into threo isomers by thionyl chloride treatment of their N-acetyl derivatives and alkaline hydrolysis.

  报道了一系列2-芳氧基-和2-芳基烷氧基-1-（2-哌啶基）乙醇的非对映体对的制备和分离。通过亚硫酰氯的N-乙酰基衍生物的亚硫酰氯处理和碱水解，将赤型氨基醇转化为苏式异构体。
• MAULEON, DAVID;PUJOL, M. DOLORS;MINGUILLON, CRISTINA;MIQUEL, JAUME, J. HETEROCYCL. CHEM., 26,(1989) N, C. 693-699
  作者：MAULEON, DAVID、PUJOL, M. DOLORS、MINGUILLON, CRISTINA、MIQUEL, JAUME

  DOI：——

  日期：——
• MAULEON, DAVID;PUJOL, MARIA DOLORS;ROSELL, GLORIA, J. MED. CHEM., 31,(1988) N 11, C. 2122-2126
  作者：MAULEON, DAVID、PUJOL, MARIA DOLORS、ROSELL, GLORIA

  DOI：——

  日期：——
• Synthesis and .beta.-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols
  作者：David Mauleon、Maria Dolors Pujol、Gloria Rosell

  DOI：10.1021/jm00119a011

  日期：1988.11

  A series of erythro- and threo-2-(aryloxy)-1-(2-piperidyl)ethanol derivatives (3) was synthesized from 2-(2-oxiranyl)pyridine for evaluation as beta-antagonists. Most compounds displayed high competitive beta-blocking potency, but they lacked significant beta 1/beta 2 selectivity. The 1-naphthoxy derivative erythro-3b was 17 (beta 1) and 33 (beta 2) times more potent than its open-chain analogue, propranolol. Within the whole series, erythro-3 diastereomers were more potent beta-blockers than the threo-3 isomers, and the potency of the latter seems to be rather insensitive to structural modification. The effect of N-methylation and of interposition of an alkyl chain between the aromatic ring and the side chain, while being detrimental to beta-blocking activity, was less marked than in the classic (aryloxy)propanolamine blockers.