2-[di(benzyloxy)phosphoryloxy]ethyl 4-nitrophenyl carbonate | 393785-25-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[di(benzyloxy)phosphoryloxy]ethyl 4-nitrophenyl carbonate
• 英文别名: 2-bis(phenylmethoxy)phosphoryloxyethyl (4-nitrophenyl) carbonate
• CAS: 393785-25-6
• 化学式: C₂₃H₂₂NO₉P
• 分子量: 487.403
• InChiKey: BJRMYKJXGQOKIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  126
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-[di(benzyloxy)phosphoryloxy]ethyl 4-nitrophenyl carbonate 在 4-二甲氨基吡啶 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 9.0h， 生成
  参考文献：
  名称：

  [EN] PHOSPHATE PRODRUGS OF CANNABINOIDS
  [FR] PROMÉDICAMENTS CANNABINOÏDES À BASE DE PHOSPHATE

  摘要：

  Phosphate prodrugs of cannabinoids are disclosed herein as are pharmaceutical compositions comprising one or more of the same. Such compounds and compositions are useful for the treatment of diseases, disorders, and/or conditions, including neurological disorders and neuropathic pain.

  公开号：

  WO2023009817A2
• 作为产物：
  描述：

  二苯基N,N'-二异丙基亚磷酰胺 在 5-甲基四氮唑 、 水 、 双氧水 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 4.0h， 生成 2-[di(benzyloxy)phosphoryloxy]ethyl 4-nitrophenyl carbonate
  参考文献：
  名称：

  [EN] PHOSPHATE PRODRUGS OF CANNABINOIDS
  [FR] PROMÉDICAMENTS CANNABINOÏDES À BASE DE PHOSPHATE

  摘要：

  Phosphate prodrugs of cannabinoids are disclosed herein as are pharmaceutical compositions comprising one or more of the same. Such compounds and compositions are useful for the treatment of diseases, disorders, and/or conditions, including neurological disorders and neuropathic pain.

  公开号：

  WO2023009817A2

文献信息

• Colchinol derivatives as angiogenesis inhibitors
  申请人：——

  公开号：US20030195173A1

  公开（公告）日：2003-10-16

  The invention related to colchinol derivatives of the formula (I): Wherein: R 1 , R 2 and R 3 are each independently hydroxy, phosphoryloxy (—OPO 3 H 2 ), C 1-4 alkoxy or an in vivo hydrolysable ester of hydroxy, with the proviso that at least 2 of R 1 , R 2 and R 3 are C 1-4 alkoxy; A is —CO—, —C(O)O—, —CON(R 8 )— (wherein R 8 is hydrogen, C 1-4 alkyl, C 1-3 alkoxyC 1-3 alkyl, aminoC 1-3 alkyl or hydroxyC 1-3 alkyl); a is an integer from 1 to 4 inclusive; R a and R b are independently selected from hydrogen, hydroxy and amino; B is —O—, —CO—, N(R 9 )CO—, —CON(R 9 )—, —N(R 9 )C(O)O—, —N(R 9 )CON(R 10 )—, —N(R 9 )SO 2 —, —SO 2 N(R 9 )— or a direct single blond (wherein R 9 and R 10 are independently selected from hydrogen, C 1-4 alkyl, C 1-3 alkoxyC 1-3 alkyl,aminoC 1-3 alkyl and hydroxyC 1-3 alkyl); b is O or an integer from 1 to 4 inclusive, (provided that when bis O, B is a single direct bond); D is carboxy, sulpho, tetrazolyl, imidazolyl, phosphoryloxy, hydroxy, amino, N-(C 1-4 alkyl)amino, N,N-di(C 1-3 alkyl)amino, or of the formula-Y 1 (CH 2 ) 0 R 11 or —NHCH(R 12 )COOH;[wherein Y 1 is a direct single bond, —O—, —C(O)—, —N(R 13 )C(O)— or —C(O)N(R 13 )— (wherein R 13 is hydrogen, C 1-4 alkyl,C 1-3 alkoxyC 2-3 alkyl, aminoC 2-3 alkyl or hydroxyC 2-3 alkyl); e is O or an integer from 1 to 4 inclusive.

  与化学相关的发明，涉及公式(I)的秋水仙碱衍生物：其中：R1、R2和R3分别独立地为羟基、磷酸酯基（—OPO3H2）、C1-4烷氧基或羟基的体内可水解酯，但至少其中2个为C1-4烷氧基；A为—CO—、—C(O)O—、—CON(R8)—（其中R8为氢、C1-4烷基、C1-3烷氧基烷基、氨基烷基或羟基烷基）；a为1到4的整数；Ra和Rb分别独立地选自氢、羟基和氨基；B为—O—、—CO—、N(R9)CO—、—CON(R9)—、—N(R9)C(O)O—、—N(R9)CON(R10)—、—N(R9)SO2—、—SO2N(R9)—或直接单键（其中R9和R10分别独立地选自氢、C1-4烷基、C1-3烷氧基烷基、氨基烷基和羟基烷基）；b为O或1到4的整数，（当b为O时，B为单一直接键）；D为羧基、磺酸基、四唑基、咪唑基、磷酸酯基、羟基、氨基、N-(C1-4烷基)氨基、N,N-二(C1-3烷基)氨基，或公式-Y1(CH2)0R11或—NHCH(R12)COOH；[其中Y1为直接单键、—O—、—C(O)—、—N(R13)C(O)—或—C(O)N(R13)—（其中R13为氢、C1-4烷基、C1-3烷氧基烷基、氨基烷基或羟基烷基）；e为O或1到4的整数。
• COLCHINOL DERIVATIVES AS ANGIOGENESIS INHIBITORS
  申请人：Angiogene Pharmaceuticals Limited

  公开号：EP1301498A1

  公开（公告）日：2003-04-16
• US6720323B2
  申请人：——

  公开号：US6720323B2

  公开（公告）日：2004-04-13
• US6846925B2
  申请人：——

  公开号：US6846925B2

  公开（公告）日：2005-01-25
• [EN] COLCHINOL DERIVATIVES AS ANGIOGENESIS INHIBITORS<br/>[FR] DERIVES DE COLCHINOL UTILES COMME INHIBITEURS DE L'ANGIOGENESE
  申请人：ANGIOGENE PHARM LTD

  公开号：WO2002008213A1

  公开（公告）日：2002-01-31

  The invention related to colchinol derivatives of the formula (I): Wherein: R?1, R2 and R3¿ are each independently hydroxy, phosphoryloxy (-OPO¿3?H2), C1-4alkoxy or an in vivo hydrolysable ester of hydroxy, with the proviso that at least 2 of R?1, R2 and R3¿ are C¿1-4?alkoxy; A is -CO-, -C(O)O-, -CON(R?8¿)- (wherein R8 is hydrogen, C¿1-4?alkyl, C1-3alkoxyC1-3alkyl, aminoC1-3alkyl or hydroxyC1-3alkyl); a is an integer from 1 to 4 inclusive; R?a and Rb¿ are independently selected from hydrogen, hydroxy and amino; B is -O-, -CO-, N(R9)CO-, -CON(R9)-, -N(R9)C(O)O-, -N(R?9)CON(R10¿)-, -N(R9)SO2-, -SO2N(R9)- or a direct single blond (wherein R?9 and R10¿ are independently selected from hydrogen, C¿1-4?alkyl, C1-3alkoxyC1-3alkyl,aminoC1-3alkyl and hydroxyC1-3alkyl); b is O or an integer from 1 to 4 inclusive, (provided that when bis O, B is a single direct bond); D is carboxy, sulpho, tetrazolyl, imidazolyl, phosphoryloxy, hydroxy, amino, N-(C1-4alkyl)amino, N,N-di(C1-3alkyl)amino, or of the formula-Y?1(CH¿2)0R11 or -NHCH(R12)COOH;[wherein Y1 is a direct single bond, -O-, -C(O)-, -N(R13)C(O)- or -C(O)N(R13)- (wherein R13 is hydrogen, C¿1-4?alkyl,C1-3alkoxyC2-3alkyl, aminoC2-3alkyl or hydroxyC2-3alkyl); e is O or an integer from 1 to 4 inclusive.