(E)-1-(2-fluorovinyl)-3-nitrobenzene | 1262431-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(2-fluorovinyl)-3-nitrobenzene
• 英文别名: 1-[(e)-2-Fluorovinyl]-3-nitrobenzene；1-[(E)-2-fluoroethenyl]-3-nitrobenzene
• CAS: 1262431-33-3
• 化学式: C₈H₆FNO₂
• 分子量: 167.14
• InChiKey: LUBQYSNDXACHKY-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  E-2 fluorovinyl 4-methylbenzenesulfonate 、 3-硝基苯硼酸 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 potassium phosphate 、 三环己基膦 作用下， 以 1,4-二氧六环 为溶剂， 反应 14.0h， 以99%的产率得到(E)-1-(2-fluorovinyl)-3-nitrobenzene
  参考文献：
  名称：

  Monofluorovinyl Tosylate: A Useful Building Block for the Synthesis of Terminal Vinyl Monofluorides via Suzuki−Miyaura Coupling

  摘要：

  Monofluorovinyl tosylate was developed as a practical vinyl fluoride building block to couple with a variety of arylboronic acids in the presence of a palladium catalyst. The high stereoselectivity of 2-aryl-1-fluoroethene derivatives was achieved. This approach is also applicable to the synthesis of 2,2-diaryl-1-fluoroethenes in good yields.

  DOI：

  10.1021/ol102645g

文献信息

• LEVY, J. B.;STERLING, D. M., J. ORG. CHEM., 1985, 50, N 26, 5615-5619
  作者：LEVY, J. B.、STERLING, D. M.

  DOI：——

  日期：——
• Monofluorovinyl Tosylate: A Useful Building Block for the Synthesis of Terminal Vinyl Monofluorides via Suzuki−Miyaura Coupling
  作者：He Zhang、Chang-Bing Zhou、Qing-Yun Chen、Ji-Chang Xiao、Ran Hong

  DOI：10.1021/ol102645g

  日期：2011.2.18

  Monofluorovinyl tosylate was developed as a practical vinyl fluoride building block to couple with a variety of arylboronic acids in the presence of a palladium catalyst. The high stereoselectivity of 2-aryl-1-fluoroethene derivatives was achieved. This approach is also applicable to the synthesis of 2,2-diaryl-1-fluoroethenes in good yields.