3-methyl-3'-nitrobiphenyl-2-carbaldehyde O-methyl oxime | 1201946-21-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-3'-nitrobiphenyl-2-carbaldehyde O-methyl oxime
• 英文别名: (E)-N-methoxy-1-[2-methyl-6-(3-nitrophenyl)phenyl]methanimine
• CAS: 1201946-21-5
• 化学式: C₁₅H₁₄N₂O₃
• 分子量: 270.288
• InChiKey: DKFDADHLAYJRSC-MHWRWJLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-methylbenzaldehyde O-methyl oxime 、 3-硝基苯硼酸 在 2,6-二甲氧基吡啶 、 palladium diacetate 、 copper(II) bis(trifluoromethanesulfonate) 、 对苯醌 作用下， 以 1,4-二氧六环 为溶剂， 以81%的产率得到3-methyl-3'-nitrobiphenyl-2-carbaldehyde O-methyl oxime
  参考文献：
  名称：

  Pd-Catalyzed C−H Functionalizations of O-Methyl Oximes with Arylboronic Acids

  摘要：

  Useful methods have been developed to construct ortho-arylated aryl aldoximes, aryl ketoximes, and fluorenones via Pd(II)-catalyzed direct C-H arylation by using arylboronic acids as arylating reagents based on the analysis of the pathways of direct functionalization of aryl aldoximes.

  DOI：

  10.1021/ol902552v

文献信息

• Pd-Catalyzed C−H Functionalizations of <i>O</i>-Methyl Oximes with Arylboronic Acids
  作者：Chang-Liang Sun、Na Liu、Bi-Jie Li、Da-Gang Yu、Yang Wang、Zhang-Jie Shi

  DOI：10.1021/ol902552v

  日期：2010.1.1

  Useful methods have been developed to construct ortho-arylated aryl aldoximes, aryl ketoximes, and fluorenones via Pd(II)-catalyzed direct C-H arylation by using arylboronic acids as arylating reagents based on the analysis of the pathways of direct functionalization of aryl aldoximes.