N-(4-methylbenzyl)acrylamide | 66005-03-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-methylbenzyl)acrylamide
• 英文别名: N-(4-methylphenylmethyl)propenamide；N-[(4-methylphenyl)methyl]prop-2-enamide
• CAS: 66005-03-6
• 化学式: C₁₁H₁₃NO
• 分子量: 175.23
• InChiKey: KMVFXRUAQUPAJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(4-methylbenzyl)acrylamide 、 4-氨甲基苯甲酸甲酯盐酸盐 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以84%的产率得到methyl 4-(((3-((4-methylbenzyl)amino)-3-oxopropyl)amino)methyl)benzoate hydrochloride
  参考文献：
  名称：

  具有抗神经母细胞瘤和抗胶质母细胞瘤活性的β肽样HDAC抑制剂的设计，合成和生物学评估†

  摘要：

  组蛋白脱乙酰基酶（HDAC）已被确定为治疗神经母细胞瘤和胶质母细胞瘤的有前途的表观遗传药物靶标。在这项工作中，我们合理地设计了一类新型的类肽基组蛋白脱乙酰基酶抑制剂（HDACi）。使用四步方案合成了β-类肽封端的HDACi的微型文库。在生化分析中筛选所有化合物对HDAC1和HDAC6的抑制作用，并进行对接研究以合理化所观察到的选择性。进一步检查合成的化合物对一组神经母细胞瘤和胶质母细胞瘤细胞系的肿瘤细胞抑制活性。特别是，对HDAC1和HDAC6具有有效活性的非选择性化合物表现出强大的抗增殖作用。最有前途的HDACi，化合物6i，对所研究的所有五个癌细胞系均表现出亚微摩尔肿瘤细胞抑制潜力（IC 50：0.21-0.67μM），并超过了FDA批准的HDACi伏立诺他活性。

  DOI：

  10.1039/c8md00454d
• 作为产物：
  描述：

  (4-甲基苯基)甲醇 、 丙烯腈 在 Nafion-H 作用下， 反应 24.0h， 以75%的产率得到N-(4-methylbenzyl)acrylamide
  参考文献：
  名称：

  全氟磺酸树脂 (Nafion-H) 催化苯甲醇的 Ritter 反应

  摘要：

  发现全氟磺酸树脂 (Nafion-H) 催化剂可有效促进苯甲醇与腈（如乙腈、丙烯腈和苯甲腈）的 Ritter 反应，生成相应的 N-苄基酰胺。

  DOI：

  10.3184/030823407x262436

文献信息

• Process for the preparation of pigment dispersion, pigment dispersion obtained by the same, ink jet recording ink comprising the same, and recording method and recorded material using the same
  申请人：SEIKO EPSON CORPORATION

  公开号：US20020075369A1

  公开（公告）日：2002-06-20

  Provided is a process for the preparation of a pigment dispersion which comprises a pigment surface treatment step of introducing at least one hydrophilic dispersibility-providing group onto the surface of a pigment directly and/or with the interposition of a polyvalent group, and a dispersion step of dispersing a surface-treated pigment obtained at the surface treatment step in an aqueous medium, characterized in that the dispersion step involves the dispersion of the surface-treated pigment in admixture with a wetting agent and water and a resin for providing dispersibility and/or fixability is added during and/or after the dispersion step.

  提供了一种颜料分散制备的工艺，包括颜料表面处理步骤，该步骤将至少一个亲水性分散性提供基团直接和/或通过多价基团介质引入到颜料表面上，以及将在表面处理步骤中获得的经表面处理的颜料分散于水介质中的分散步骤。其特征在于，分散步骤包括将经表面处理的颜料与润湿剂和水混合分散，以及在分散步骤期间和/或之后添加提供分散性和/或固定性的树脂。
• Ink composition for electrostatic ink-jet recording and method of ink-jet recording
  申请人：Kasai Seishi

  公开号：US20050070630A1

  公开（公告）日：2005-03-31

  An ink composition for electrostatic ink-jet recording comprises: a dispersion medium; and a charged particle comprising a colorant, wherein the charged particle contains at least one of an onium salt compound and an onium salt group-containing polymer. A method of ink jet recording comprises an ink droplet of the ink composition by using an electrostatic field.

  一种用于静电喷墨记录的墨水组合物包括：分散介质；以及包含着色剂的带电粒子，其中所述带电粒子包含至少一种onium盐化合物和onium盐基聚合物中的一种。一种喷墨记录的方法包括使用静电场将墨水组合物的墨滴喷出。
• Aqueous based fire foam compositions containing hydrocarbyl sulfide terminated oligomer stabilizers
  申请人：CIBA-GEIGY AG

  公开号：EP0083312A1

  公开（公告）日：1983-07-06

  This invention relates to aqueous based fire fighting foams containing a stabilizing amount of an oligomer of the formula wherein R1 is an oleophilic aryl, araliphatic, aliphatic or cyclo-aliphatic group having up to 25 carbon atoms; E is a direct bond, or an organic covalently bonded divalent linking group, n is 0, 1 or 2, [M1] is a hydrophilic acrylamido monomer unit, [M2] is a copolymerizable non-acrylamido hydrophilic monomer unit, [M3] is a copolymerizable hydrophobic monomer unit, the average of the sum of x, y and z is between about 3 and about 500, andis between 1 and about 0.5. These stabilizing oligomer additives in aqueous based fire fighting foams improve foam expansion, foam drainage and fire extinguishing times.

  本发明涉及一种水基灭火泡沫，该泡沫含有稳定量的式中低聚物 其中 R1 是亲油芳基、脂肪族、脂肪族或环脂肪族基团，具有多达 25 个碳原子；E是直接键或有机共价键二价连接基团，n是0、1或2，[M1]是亲水性丙烯酰胺基单体单元，[M2]是可共聚的非丙烯酰胺基亲水性单体单元，[M3]是可共聚的疏水性单体单元，x、y和z之和的平均值在约3和约500之间，且在1和约0之间。5.水基灭火泡沫中的这些稳定低聚物添加剂可改善泡沫膨胀、泡沫排出和灭火时间。
• Graft copolymer and process for producing the same
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0490269A1

  公开（公告）日：1992-06-17

  There is provided a process for producing a styrenic graft copolymer which comprises coplymerizing a styrenic monomer and a styrenic monomer having a hydrocarbon radical with an unsaturated bond in the presence of a catalyst comprising as primary ingredient (A) a transition metal compound and (B) a contact product of an organoaluminum compound and a condensation agent or (C) a compound which produces an ionic complex by reacting with the above-mentioned transition metal compound and subsequently graft polymerizing an ethylenically unsaturated monomer onto the resultant styrenic copolymer. The above-described styrenic graft copolymer is greatly improved in terms of compatibility, adhesivity, coatability and wettability while preserving heat resistance and chemical resistance thereof, and thus effective as a variety of constructional materials and compatibilizing agents. Furthermore, the composition or multi-layer material comprising the above-mentioned styrenic graft copolymer is widely utilized in a variety of application field including film, sheet, especially stampable sheet, container, packaging material, automobile parts, electrical and electronic parts, etc.

  提供了一种生产苯乙烯接枝共聚物的工艺，该工艺包括在催化剂存在下，使苯乙烯单体和具有不饱和键烃基的苯乙烯单体共聚，催化剂的主要成分包括(A)过渡金属化合物和(B)有机铝化合物与缩合剂的接触产物或(C)通过与上述过渡金属化合物反应产生离子络合物的化合物，然后将乙烯基不饱和单体接枝聚合到生成的苯乙烯共聚物上。上述过渡金属化合物反应生成离子络合物的化合物，然后将乙烯不饱和单体接枝聚合到生成的苯乙烯共聚物上。 上述苯乙烯接枝共聚物在保持其耐热性和耐化学性的同时，在相容性、粘合性、涂覆性和润湿性方面得到了极大的改善，因此可以有效地用作各种建筑材料和相容剂。此外，由上述苯乙烯接枝共聚物组成的组合物或多层材料可广泛应用于各种应用领域，包括薄膜、片材，尤其是可冲压片材、容器、包装材料、汽车零件、电子电气零件等。
• Aqueus ink for inkjet printing
  申请人：KAO CORPORATION

  公开号：EP0791610A2

  公开（公告）日：1997-08-27

  An aqueous inkjet printing ink with excellent water resistance, wherein scorching onto a printer head scarcely occurs, the amount of a hydrophobic dye contained in an aqueous dispersion of a vinyl polymer can be increased, and sharp printed letters having deep color can be provided. The aqueous ink product for inkjet printing comprises a dispersion of a vinyl polymer obtained by copolymerizing one or more selected from a silicone macromer, an acrylamide monomer and a methacrylamide monomer (not having a salt-forming group), or a styrene macromer of a styrene homopolymer or a styrene copolymer having a polymerizable functional group at one terminal end, a polymerizable unsaturated monomer having the salt-forming group, and a monomer capable of polymerizing with these monomers in the presence of a radical polymerization initiator, a hydrophobic dye being contained in the dispersion.

  一种水性喷墨打印墨水具有极佳的耐水性，在这种墨水中，打印机头几乎不会发生烧焦现象，乙烯基聚合物水性分散体中所含的疏水性染料的量可以增加，并且可以提供具有深色的清晰打印字。用于喷墨打印的水性墨水产品包括乙烯基聚合物的分散体，该分散体通过共聚硅酮大单体、丙烯酰胺单体和甲基丙烯酰胺单体（不含成盐基团）中的一种或多种单体而获得、或苯乙烯均聚物或苯乙烯共聚物的苯乙烯大单体（其一个末端具有可聚合的官能团）、具有成盐基团的可聚合不饱和单体和在自由基聚合引发剂存在下能与这些单体聚合的单体，分散体中含有疏水性染料。