2-硝基-4-羧基苯基-N,N-联苯基氨基甲酸酯 | 10556-88-4

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-硝基-4-羧基苯基-N,N-联苯基氨基甲酸酯
• 中文别名: 2-硝基-4-羧基苯基-N,N-氨基甲酸二苯酯
• 英文名称: 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate
• 英文别名: 4-(diphenylcarbamoyloxy)-3-nitrobenzoic acid
• CAS: 10556-88-4
• 化学式: C20H14N2O6
• mdl: MFCD00057605
• 分子量: 378.3
• InChiKey: RLNYDAFUTZRAIW-UHFFFAOYSA-N

物化性质

• 沸点：
  561.8±50.0 °C(Predicted)
• 密度：
  1.433±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  遵照规格使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 海关编码：
  2924299090

文献信息

• Cancer diagnostics, therapeutics, and drug discovery associated with macropinocytosis
  申请人：New York University

  公开号：US11209420B2

  公开（公告）日：2021-12-28

  The present invention is directed to methods of inhibiting both proliferation and survival of cancer cells and for treating a subject having cancer. The present invention is further directed to methods of diagnosing cancer in a subject and identifying cancer therapeutics.

  本发明涉及抑制癌细胞增殖和存活以及治疗癌症患者的方法。本发明还涉及诊断受试者癌症和确定癌症疗法的方法。
• Verfahren zum Identifizieren gewebstypischer, unlöslicher Cytoskelettproteine
  申请人：PROGEN Biotechnik GmbH

  公开号：EP0267355B1

  公开（公告）日：1991-09-18
• Protection From And Treatment Of Prion Protein Infection
  申请人：Dowdy F. Steven

  公开号：US20080027025A1

  公开（公告）日：2008-01-31

  The disclosure for the first time provides an understanding of the mechanism of prion protein infection: prion proteins contain a cationic protein transduction domain (PTD) that interacts with the cell surface such that it induces macropinocytosis and enters the cytoplasm.
• CANCER DIAGNOSTICS, THERAPEUTICS, AND DRUG DISCOVERY ASSOCIATED WITH MACROPINOCYTOSIS
  申请人：Bar-Sagi Dafna

  公开号：US20140057905A1

  公开（公告）日：2014-02-27

  The present invention is directed to methods of inhibiting both proliferation and survival of cancer cells and for treating a subject having cancer. The present invention is further directed to methods of diagnosing cancer in a subject and identifying cancer therapeutics.
• COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF HEARING LOSS
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITALEINDHOVEN

  公开号：US20200093923A1

  公开（公告）日：2020-03-26

  Methods and compositions using an inhibitor of EGFR signaling for prevention or an inhibitor of EGFR signaling and a nucleic acid molecule encoding an atonal-associated factor for treatment of hearing loss are described.