2-硝基吡啶-4-甲酸甲酯 | 26218-82-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-硝基吡啶-4-甲酸甲酯
• 英文名称: 2-nitro-isonicotinic acid methyl ester
• 英文别名: 2-Nitro-isonicotinsaeure-methylester；methyl 2-nitroisonicotinate；2-Nitro-isonicotinsaeuremethylester；2-Nitro-4-methoxycarbonylpyridin；Methyl-2-nitro-isonicotinat；6-Nitro-isonicotinat；methyl 2-nitropyridine-4-carboxylate
• CAS: 26218-82-6
• 化学式: C₇H₆N₂O₄
• 分子量: 182.136
• InChiKey: FSBDZOPIXYRGJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2-硝基吡啶-4-甲酸甲酯 在 乙醇 、 一水合肼 作用下， 生成 2-nitropyridine-4-carbohydrazide
  参考文献：
  名称：

  Notes - Preparation of 2-Nitroisonicotinic Acid Hydrazide and 2-Aminoisonicotinic Acid Hydrazide

  摘要：

  DOI：

  10.1021/jo01355a628
• 作为产物：
  描述：

  甲醇 、 2-硝基-4-吡啶甲酸 在 PPA 作用下， 生成 2-硝基吡啶-4-甲酸甲酯
  参考文献：
  名称：

  Notes - Preparation of 2-Nitroisonicotinic Acid Hydrazide and 2-Aminoisonicotinic Acid Hydrazide

  摘要：

  DOI：

  10.1021/jo01355a628

文献信息

• Substituted indolizine-like compounds and methods of use
  申请人：——

  公开号：US20030195221A1

  公开（公告）日：2003-10-16

  Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的类似吲哚啉的化合物对治疗疾病，如TNF-α、IL-1β、IL-6和/或IL-8介导的疾病，以及其他疾病，如癌症、疼痛和糖尿病具有有效性。本发明涵盖了新型化合物、类似物、前药和其药用可接受盐、制药组合物以及治疗涉及炎症、癌症、疼痛、糖尿病等疾病和其他疾患或情况的方法。该发明还涉及制备此类化合物的方法，以及在此类过程中有用的中间体。
• Substituted heterocyclic compounds and methods of use
  申请人：Liu Longbin

  公开号：US20050043301A1

  公开（公告）日：2005-02-24

  The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R 1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R 1 is additionally substituted; and R 2 is a substituted C 1-6 alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

  本发明涉及具有一般式的化合物或其药学上可接受的盐，其中R1是饱和或不饱和的5、6或7成员环，含有0、1、2或3个来自N、O和S的原子，其中环可能与苯环融合，并且被0、1或2个氧代基取代，并且R1还被取代；R2是取代的C1-6烷基。还包括一种预防或治疗炎症、类风湿性关节炎、帕盖特病、骨质疏松症、多发性骨髓瘤、葡萄膜炎、急性或慢性骨髓性白血病、胰岛素β细胞破坏、骨关节炎、类风湿脊柱炎、痛风性关节炎、炎症性肠病、成人呼吸窘迫综合征（ARDS）、牛皮癣、克罗恩病、过敏性鼻炎、溃疡性结肠炎、过敏性休克、接触性皮炎、哮喘、肌肉退化、消瘦症、Reiter综合征、I型糖尿病、II型糖尿病、骨吸收疾病、移植物抗宿主反应、阿尔茨海默病、中风、心肌梗死、缺血再灌注损伤、动脉粥样硬化、脑外伤、多发性硬化症、脑型疟疾、败血症、感染性休克、毒性休克综合征、发热、HIV-1、HIV-2、HIV-3、巨细胞病毒（CMV）、流感、腺病毒、单纯疱疹病毒或带状疱疹感染引起的肌肉疼痛的方法，包括向哺乳动物施用上述化合物的有效量。
• Pyridine derivatives and their use as anticoccidial agents
  申请人：Sankyo Company Limited

  公开号：US04054663A1

  公开（公告）日：1977-10-18

  Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms. They are highly effective in the treatment of coccidiosis.

  吡啶衍生物具有以下公式：其中R.sub.1是具有1至3个碳原子的烷基基团；R.sub.2是氢原子或具有1至3个碳原子的烷基基团；R.sub.3是氢原子，具有1至4个碳原子的烷基基团，具有3或4个碳原子的烯基基团，具有1或2个碳原子并且羟基作为取代基的烷基基团，具有1至18个碳原子的烷酰基团，具有3至11个碳原子的烯酰基团，在芳环中具有6个或10个碳原子的芳基酰基团，并且可选择烷基，烷氧基，乙酰氨基，氰基或卤素作为取代基，杂环酰基，具有1至4个碳原子的烷基基团的烷基氨基甲酰基团，烯基氨基甲酰基团或羟基；n是0到2的整数，包括0和2；当n为2时，R.sub.1'可能相同也可能不同；但是当R.sub.2为具有1至3个碳原子的烷基基团时，R.sub.3为具有1至4个碳原子的烷基基团。它们在球虫病的治疗中非常有效。
• Substituted pyrimidine compounds and methods of use
  申请人：Amgen Inc.

  公开号：US20030069425A1

  公开（公告）日：2003-04-10

  Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选择的新型代替嘧啶类化合物可用于预防和治疗诸如TNF-α、IL-1β、IL-6和/或IL-8介导的疾病，以及其他疾病，如疼痛和糖尿病。该发明涵盖了新型化合物、类似物、前药及其药学上可接受的盐、制药组合物和用于预防和治疗涉及炎症、疼痛、糖尿病等疾病和其他疾病或病况的方法。该发明还涉及制备这种化合物的过程，以及在这些过程中有用的中间体。
• Substituted pyridone compounds and methods of use
  申请人：Amgen Inc.

  公开号：US20030073704A1

  公开（公告）日：2003-04-17

  Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的新型嘧啶酮和吡啶酮化合物对于预防和治疗疾病（如TNF-α、IL-1β、IL-6和/或IL-8介导的疾病）以及其他疾病（如疼痛和糖尿病）是有效的。该发明涵盖了新型化合物、类似物、前药和其药学上可接受的盐、制药组合物以及用于预防和治疗涉及炎症、疼痛、糖尿病等疾病和其他疾患或病况的方法。该发明还涉及制造这些化合物的过程以及在这些过程中有用的中间体。

表征谱图