2-羟基-1,2,3-丙三羧酸三(十八烷基酯) | 7775-50-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-羟基-1,2,3-丙三羧酸三(十八烷基酯)
• 中文别名: 三硬脂醇柠檬酸酯
• 英文名称: Stearyl citrate
• 英文别名: Trioctadecyl 2-hydroxypropane-1,2,3-tricarboxylate
• CAS: 7775-50-0
• 化学式: C₆₀H₁₁₆O₇
• 分子量: 949.577
• InChiKey: UKBHVNMEMHTWQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  25.5
• 重原子数：
  67
• 可旋转键数：
  59
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  99.1
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

代谢

因为任何实验中都没有记录到低钙血症，所以假设硬脂酸柠檬酸盐被快速代谢或排泄，并且以慢速水解。/硬脂酸柠檬酸盐/

BECAUSE NO HYPOCALCEMIA HAS BEEN NOTED IN ANY EXPERIMENT, IT IS ASSUMED THAT STEARYL CITRATE IS RAPIDLY METABOLIZED OR EXCRETED AND HYDROLYZED AT A SLOW RATE. /STEARYL CITRATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在大鼠中，当饲料中添加了含有10-15%三硬脂酸柠檬酸酯的硬脂酸柠檬酸酯混合物，剂量为0.5-10%，持续2年时，没有发生任何效果。同样，喂食了2%和10%剂量的家兔，持续6周，以及喂食了3%剂量的狗，持续12周，也没有出现任何效果。

NO EFFECTS OCCURRED IN RATS WHEN...MIXTURE /OF STEARYL CITRATE CONTAINING 10-15% TRISTEARYL CITRATE/ WAS FED AT 0.5-10% IN THE DIET FOR 2 YR. SIMILARLY, NO EFFECTS OCCURRED WITH RABBITS FED 2 & 10% FOR 6 WK, AND DOGS 3% FOR 12 WK.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  硬脂醇 在 potassium penicillin V 、 柠檬酸 作用下， 生成 2-羟基-1,2,3-丙三羧酸三(十八烷基酯)
  参考文献：
  名称：

  USE OF TWO-TAIL LONG-CHAIN ANIONIC SURFACTANTS IN AQUEOUS POLYURETHANE DISPERSIONS

  摘要：

  The use of two-tail long-chain anionic surfactants as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

  公开号：

  US20210403493A1

文献信息

• [EN] NOVEL ANTIMICROBIAL PEPTIDES AND THEIR APPLICATION<br/>[FR] NOUVEAUX PEPTIDES ANTIMICROBIENS ET LEUR APPLICATION
  申请人：INFINITEC ACTIVOS S L

  公开号：WO2015135896A1

  公开（公告）日：2015-09-17

  The present invention relates to a compound of formula (I) and to compositions comprising said compound, as well as the use of said compound and/or said compositions to prevent fungal and/or bacterial growth.

  本发明涉及式(I)的化合物，以及包含该化合物的组合物，以及使用该化合物和/或所述组合物来防止真菌和/或细菌生长。
• [EN] POLYEHYLENE GLYCOL-PEPTIDE COPPER COMPLEXES AND COMPOSITIONS AND METHODS RELATED THERETO<br/>[FR] COMPLEXES DE POLYETHYLENE GLYCOL-PEPTIDE-CUIVRE ET COMPOSITIONS ET METHODES Y ETANT ASSOCIEES
  申请人：PROCYTE CORP

  公开号：WO2006023465A1

  公开（公告）日：2006-03-02

  This invention relates to compositions comprising polyethylene glycol molecules coupled to peptide copper complexes, and, additionally, to such compositions formulated for use as pharmaceutical and cosmetic products, as well as to medical devices that comprise such compositions.

  这项发明涉及包含聚乙二醇分子偶联到肽铜络合物的组合物，此外，还涉及配制用作药用和化妆品产品的这种组合物，以及包含这种组合物的医疗器械。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• [EN] 2,3,7-TRIMETHYLOCT-6-ENYL ACETATE AND 3,7-DIMETHYL-2-METHYLENE-OCT-6-ENYL ACETATE AND DERIVATIVES THEREOF AND THEIR USE AS AROMA CHEMICALS<br/>[FR] ACÉTATE DE 2,3,7-TRIMÉTHYLOCT-6-ÉNYLE ET DE 3,7-DIMÉTHYL-2-MÉTHYLÈNE-OCT-6-ÉNYLE, LEURS DÉRIVÉS ET LEUR UTILISATION EN TANT QUE PRODUITS CHIMIQUES AROMATIQUES
  申请人：BASF SE

  公开号：WO2018206415A1

  公开（公告）日：2018-11-15

  The present invention relates to 2,3,7-Trimethyloct-6-enyl acetate and 3,7-dimethyl-2-methylene-oct-6-enyl acetate and derivatives thereof and their use as aroma chemicals.

  本发明涉及2,3,7-三甲基辛-6-烯基醋酸酯、3,7-二甲基-2-亚甲基辛-6-烯基醋酸酯及其衍生物，以及它们作为香料化学品的用途。
• [EN] PIM KINASE INHIBITOR COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS D'INHIBITEUR DE KINASE PIM ET UTILISATIONS ASSOCIÉES
  申请人：SNAP BIO INC

  公开号：WO2020223306A1

  公开（公告）日：2020-11-05

  This disclosure relates to compounds and compositions useful as inhibitors of PIM kinases. Also provided are methods of synthesis and methods of use of PIM inhibitors in treating individuals suffering from cancerous malignancies.

  这份披露涉及到作为PIM激酶抑制剂的化合物和组合物，同时提供了合成方法和在治疗患有癌症恶性肿瘤的个体中使用PIM抑制剂的方法。