(2-Carbonochloridoyl-5-fluorophenyl) thiohypochlorite | 1027196-81-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Carbonochloridoyl-5-fluorophenyl) thiohypochlorite
• CAS: 1027196-81-1
• 化学式: C₇H₃Cl₂FOS
• 分子量: 225.071
• InChiKey: XOVVSMINQXARMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-Carbonochloridoyl-5-fluorophenyl) thiohypochlorite 在 氨 作用下， 以 四氯化碳 为溶剂， 反应 2.0h， 生成 6-氟-苯并[d]异噻唑-3-酮
  参考文献：
  名称：

  Antimicrobial activity of fluorinated 1,2-benzisothiazol-3(2H)-ones and 2,2′-dithiobis(benzamides)

  摘要：

  Fluoro and trifluoromethyl derivatives of 1,2-benzisothiazol-3(2H)-ones and the 2,2'-dithiobis(benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram-positive microorganisms and a few derivatives displayed some activity against Gram-negative strains. Structure-activity relationships are proposed.

  DOI：

  10.1016/0223-5234(94)90132-5
• 作为产物：
  描述：

  2,2'-dithiobis[4-fluorobenzoyl chloride] 在 氯 作用下， 以 四氯化碳 为溶剂， 生成 (2-Carbonochloridoyl-5-fluorophenyl) thiohypochlorite
  参考文献：
  名称：

  Antimicrobial activity of fluorinated 1,2-benzisothiazol-3(2H)-ones and 2,2′-dithiobis(benzamides)

  摘要：

  Fluoro and trifluoromethyl derivatives of 1,2-benzisothiazol-3(2H)-ones and the 2,2'-dithiobis(benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram-positive microorganisms and a few derivatives displayed some activity against Gram-negative strains. Structure-activity relationships are proposed.

  DOI：

  10.1016/0223-5234(94)90132-5

文献信息

• Antimicrobial activity of fluorinated 1,2-benzisothiazol-3(2H)-ones and 2,2′-dithiobis(benzamides)
  作者：ML Carmellino、G Pagani、M Pregnolato、M Terreni、F Pastoni

  DOI：10.1016/0223-5234(94)90132-5

  日期：1994.1

  Fluoro and trifluoromethyl derivatives of 1,2-benzisothiazol-3(2H)-ones and the 2,2'-dithiobis(benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram-positive microorganisms and a few derivatives displayed some activity against Gram-negative strains. Structure-activity relationships are proposed.