2-Amino-phenylhydrazin | 22713-39-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-phenylhydrazin
• 英文别名: o-Amino-phenylhydrazin；2-hydrazino-aniline；2-Hydrazino-anilin；2-Hydrazino-1-amino-benzol；2-Aminophenylhydrazine；2-hydrazinylaniline
• CAS: 22713-39-9
• 化学式: C₆H₉N₃
• mdl: MFCD19216530
• 分子量: 123.158
• InChiKey: OZPGBDVJESXYAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Amino-phenylhydrazin 在 盐酸 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.75h， 生成
  参考文献：
  名称：

  A novel series of pyrazolylpiperidine N-type calcium channel blockers

  摘要：

  Selective blockers of the N-type calcium channel have proven to be effective in animal models of chronic pain. However, even though intrathecally delivered synthetic x-conotoxin MVIIA from Conus magnus (ziconotide [Prialt (R)]) has been approved for the treatment of chronic pain in humans, its mode of delivery and narrow therapeutic window have limited its usefulness. Therefore, the identification of orally active, small-molecule N-type calcium channel blockers would represent a significant advancement in the treatment of chronic pain. A novel series of pyrazole-based N-type calcium channel blockers was identified by structural modification of a high-throughput screening hit and further optimized to improve potency and metabolic stability. In vivo efficacy in rat models of inflammatory and neuropathic pain was demonstrated by a representative compound from this series. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.075
• 作为产物：
  描述：

  2-硝基苯肼 在 Cu(OH)x impregnated on Fe₃O₄ 、 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 0.28h， 以89%的产率得到2-Amino-phenylhydrazin
  参考文献：
  名称：

  Magnetically nano core–shell Fe3O4@Cu(OH)x: a highly efficient and reusable catalyst for rapid and green reduction of nitro compounds

  摘要：

  磁性可分离的纳米核壳结构Fe3O4@Cu(OH)x（含铜量为22%）通过向CuCl2·2H2O和纳米Fe3O4的水混合物中加入氢氧化钠制备而成。通过X射线荧光（XRF）、X射线衍射（XRD）、原子吸收光谱（AAS）、扫描电子显微镜（SEM）、磁滞回线（VSM）和Brunner–Emmett–Teller（BET）分析对负载的氢氧化铜进行了表征。这种核壳结构纳米催化剂对各种硝基化合物还原为其相应胺类化合物的反应表现出优异的催化活性（采用NaBH4作为还原剂）。所有反应在55-60°C的水中进行，3-15分钟内即可获得高至优异产率的胺类化合物。核壳结构Cu(OH)x催化剂的重复使用性已测试9次，其催化活性未见显著损失。

  DOI：

  10.1007/s13738-016-0962-3

文献信息

• Magnetically nano core–shell Fe3O4@Cu(OH)x: a highly efficient and reusable catalyst for rapid and green reduction of nitro compounds
  作者：Zahra Shokri、Behzad Zeynizadeh、Seyed Ali Hosseini、Behrooz Azizi

  DOI：10.1007/s13738-016-0962-3

  日期：2017.1

  Magnetically separable nano core–shell Fe3O4@Cu(OH)x with 22 % Cu content was prepared by the addition of sodium hydroxide to a mixture of CuCl2·2H2O and nano Fe3O4 in water. Characterization of the impregnated copper hydroxide was carried out by X-ray fluorescence (XRF), X-ray diffraction (XRD) atomic absorption spectroscopy (AAS), scanning electron microscopy (SEM), value stream mapping (VSM) and Brunauer–Emmett–Teller (BET) analysis. The core–shell nanocatalyst exhibited the excellent catalytic activity toward reduction of various nitro compounds to the corresponding amines with NaBH4. All reactions were carried out in H2O (55–60 °C) within 3–15 min to afford amines in high to excellent yields. Reusability of core–shell Cu(OH)x catalyst was examined 9 times without significant loss of its catalytic activity.

  磁性可分离的纳米核壳结构Fe3O4@Cu(OH)x（含铜量为22%）通过向CuCl2·2H2O和纳米Fe3O4的水混合物中加入氢氧化钠制备而成。通过X射线荧光（XRF）、X射线衍射（XRD）、原子吸收光谱（AAS）、扫描电子显微镜（SEM）、磁滞回线（VSM）和Brunner–Emmett–Teller（BET）分析对负载的氢氧化铜进行了表征。这种核壳结构纳米催化剂对各种硝基化合物还原为其相应胺类化合物的反应表现出优异的催化活性（采用NaBH4作为还原剂）。所有反应在55-60°C的水中进行，3-15分钟内即可获得高至优异产率的胺类化合物。核壳结构Cu(OH)x催化剂的重复使用性已测试9次，其催化活性未见显著损失。
• Encapsulation of Pd(II) into superparamagnetic nanoparticles grafted with EDTA and their catalytic activity towards reduction of nitroarenes and Suzuki-Miyaura coupling
  作者：Kobra Azizi、Ehsan Ghonchepour、Meghdad Karimi、Akbar Heydari

  DOI：10.1002/aoc.3258

  日期：2015.4

  Fe3O4@EDTA–Pd(II) was screened for the Suzuki reaction and reduction of nitro compounds in water. The Pd content of the catalyst was measured to be 0.28 mmol Pd g−1. In addition, the Fe3O4@EDTA–Pd catalyst can be easily separated and recovered with an external permanent magnet. The anchored solid catalyst can be recycled efficiently and reused five times with only a very slight loss of catalytic activity

  通过将Pd（II）固定在乙二胺四乙酸涂层的Fe 3 O 4（Fe 3 O 4 @EDTA）磁性纳米粒子上，合成了一种坚固，安全且可磁回收的钯催化剂。由此获得的Fe 3 O 4磁性纳米粒子负载的Pd（II）-EDTA络合催化剂的特征在于扫描和透射电子显微镜，热重分析，振动样品磁力分析，X射线衍射，电感耦合等离子体原子发射和傅里叶变换红外光谱学。铁3 O 4筛选了@ EDTA-Pd（II）的铃木反应和水中硝基化合物的还原。测得催化剂的Pd含量为0.28mmol Pd g -1。另外，Fe 3 O 4 @ EDTA-Pd催化剂可以很容易地用外部永磁体分离和回收。锚固的固体催化剂可以有效地再循环并重复使用五次，而催化活性只会非常轻微地损失。版权所有©2015 John Wiley＆Sons，Ltd.
• Green and convenient protocols for the efficient reduction of nitriles and nitro compounds to corresponding amines with NaBH4 in water catalyzed by magnetically retrievable CuFe2O4 nanoparticles
  作者：Behzad Zeynizadeh、Farkhondeh Mohammad Aminzadeh、Hossein Mousavi

  DOI：10.1007/s11164-019-03794-4

  日期：2019.6

  er and Barrett–Joyner–Halenda analyses. The prepared magnetically copper ferrite nanocomposite was successfully applied as a simple, cost-effective, practicable, and recoverable catalyst on the green, highly efficient, fast, base-free, and ligand-free reduction of nitriles and also on the affordable and eco-friendly reduction of nitro compounds with the broad substrate scope to the corresponding amines

  摘要 在这项研究中，首先，CuFe 2 O 4通过简单的操作制备纳米颗粒。所述纳米颗粒的结构通过傅里叶变换红外光谱，X射线衍射，扫描电子显微镜，透射电子显微镜，能量色散X射线光谱，电感耦合等离子体发射光谱，振动样品磁力计以及Brunauer – Emmett-Teller和Barrett-Joyner-Halenda分析。制备的磁性铜铁氧体纳米复合材料已成功用于绿色，高效，快速，无碱和无配体的腈还原反应中，以及在价格可承受且生态环保的简单，经济高效，实用且可回收的催化剂。 NaBH 4可以将具有宽泛底物范围的硝基化合物友好还原为相应的胺 在水中回流时，收率高至优异。 图形概要
• [EN] TRAF 6 INHIBITORS<br/>[FR] INHIBITEURS DE TRAF 6
  申请人：HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM GESUNDHEIT & UMWELT GMBH

  公开号：WO2019180207A1

  公开（公告）日：2019-09-26

  The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.

  本发明涉及适用于治疗癌症、免疫疾病、帕金森病、心脏肥大或2型糖尿病的化合物，以及含有这些化合物的药物组合物。该发明还涉及包含这些化合物的配套工具组。
• [EN] FIBRE REACTIVE FORMAZAN DYES, THEIR PREPARATION AND THEIR USE<br/>[FR] COLORANTS FORMAZAN RÉACTIFS AUX FIBRES, LEUR PRÉPARATION ET LEUR UTILISATION
  申请人：HUNTSMAN ADVANCED MAT (SWITZERLAND) GMBH

  公开号：WO2017129297A1

  公开（公告）日：2017-08-03

  A reactive dye of formula (1), wherein Z1 and Z2 are each independently of the other vinyl or a radical -CH2-CH2-Y and Y is a group removable under alkaline conditions, n is the number 1, 2, 3 or 4, m is the number 2, 3 or 4, q is the number 0 or 1, and the substituents -(SO3H)n, -SO2-Z1 and -NH-CO-(CH2)m-SO2-Z2 are bound to the benzene rings A, B and/or C, said benzene rings A, B and/or C are optionally further substituted by at least one substituent selected from the group C1-C4alkyl, C1-C4alkoxy and halogen, is suitable for dyeing and printing cellulosic or amide-group-containing fibre materials.

  一种式（1）的响应性染料，其中Z1和Z2分别独立地为乙烯基或基团-CH2-CH2-Y，Y是在碱性条件下可移除的基团，n为1、2、3或4，m为2、3或4，q为0或1，取代基-(SO3H)n、-SO2-Z1和-NH-CO-(CH2)m-SO2-Z2与苯环A、B和/或C结合，所述苯环A、B和/或C可以进一步被来自C1-C4烷基、C1-C4烷氧基和卤素的至少一种取代基所取代，适用于染色和印刷纤维素或含酰胺基团的纤维材料。