N-(2-cyclohexylpropyl)-4-methoxyaniline | 1263316-78-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(2-cyclohexylpropyl)-4-methoxyaniline
• CAS: 1263316-78-4
• 化学式: C₁₆H₂₅NO
• 分子量: 247.381
• InChiKey: GGPHHXFQJYTIPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙烯基环己烷 、 N-甲基-P-氨基苯甲醚 在 [Nb{(R)-BINOL-SiPh₂Me}(NMe₂)3(HNMe₂)] 作用下， 以 氘代苯 为溶剂， 反应 11.0h， 以87%的产率得到N-(2-cyclohexylpropyl)-4-methoxyaniline
  参考文献：
  名称：

  Group 5 Metal Binaphtholate Complexes for Catalytic Asymmetric Hydroaminoalkylation and Hydroamination/Cyclization

  摘要：

  3,3'-Silylated binaphtholate tantalum and niobium complexes were shown to be efficient catalysts for the asymmetric hydroaminoalkylation of N-methylaniline derivatives and N-benzylmethylamine with simple alkenes in enantioselectivities of up to 80% ee. No hydroaminoalkylation was observed with aminoalkenes; rather, exclusive asymmetric hydroamination/cyclization took place in up to 81% ee.

  DOI：

  10.1021/om1011006

文献信息

• Group 5 Metal Binaphtholate Complexes for Catalytic Asymmetric Hydroaminoalkylation and Hydroamination/Cyclization
  作者：Alexander L. Reznichenko、Thomas J. Emge、Stephan Audörsch、Eric G. Klauber、Kai C. Hultzsch、Bernd Schmidt

  DOI：10.1021/om1011006

  日期：2011.3.14

  3,3'-Silylated binaphtholate tantalum and niobium complexes were shown to be efficient catalysts for the asymmetric hydroaminoalkylation of N-methylaniline derivatives and N-benzylmethylamine with simple alkenes in enantioselectivities of up to 80% ee. No hydroaminoalkylation was observed with aminoalkenes; rather, exclusive asymmetric hydroamination/cyclization took place in up to 81% ee.