2-(4-Biphenylyl)-5-t-butyl-1,3,4-oxadiazol | 33739-74-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Biphenylyl)-5-t-butyl-1,3,4-oxadiazol
• 英文别名: 2-biphenyl-4-yl-5-tert-butyl-[1,3,4]oxadiazole；2-Tert-butyl-5-(4-phenylphenyl)-1,3,4-oxadiazole
• CAS: 33739-74-1
• 化学式: C₁₈H₁₈N₂O
• 分子量: 278.354
• InChiKey: LZAUMPRVUWMDMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-氟苯胺 、 2-(4-Biphenylyl)-5-t-butyl-1,3,4-oxadiazol 在 对甲苯磺酸 作用下， 以 水 为溶剂， 以51%的产率得到3-(biphenyl-4-yl)-5-tert-butyl-4-(2-fluorophenyl)-4H-1,2,4-triazole
  参考文献：
  名称：

  Synthesis and Biological Evaluation of 3-Biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as Novel Glycine Transporter 1 Inhibitors

  摘要：

  We describe the preparation and evaluation of a novel series of glycine transporter 1 (GlyT1) inhibitors derived from a high-throughput screening hit The SAR studies resulted in the discovery of 3-biphenyl-4-yl-4-(2 fluorophenyl)-5-isopropyl-4H-1,2,4-triazole (6p) A pharmacokinetic study was also conducted and revealed that 6p had excellent oral bioavailability and ameliorated learning impairment in passive avoidance tasks in mice

  DOI：

  10.1021/jm101031u
• 作为产物：
  描述：

  5-双苯基-4-基-2H-四唑 、 三甲基乙酰氯 以 吡啶 为溶剂， 生成 2-(4-Biphenylyl)-5-t-butyl-1,3,4-oxadiazol
  参考文献：
  名称：

  Taber,R.L.; Binkley,E.S., Journal of Heterocyclic Chemistry, 1972, vol. 9, p. 199 - 202

  摘要：

  DOI：

文献信息

• Iridium Complex Containing Carbazole-Substituted Pyridine and Phenyl Derivatives as Main Ligand and Organic Light-Emitting Diodes Containing the Same
  申请人：Chung Kwang Choon

  公开号：US20100270540A1

  公开（公告）日：2010-10-28

  The present invention relates to a novel iridium complex into which carbazole-substituted pyridine derivatives and various substituents-substituted phenyl derivatives are introduced as main ligand and a electrophosphorescence diode containing the same as a dopant of a light-emitting layer. When the iridium complex according to the present invention is applied to an organic light-emitting diode, the heat-resistance property and the light-emitting property can be significantly improved as well as the light-emitting efficiency and the like can be significantly improved by doping the iridium complex compound into the light-emitting layer as compared to the conventional organic light-emitting diode.

  本发明涉及一种新型的铱配合物，其中以卡巴唑取代的吡啶衍生物和各种取代苯基衍生物作为主配体，并且作为发光层的掺杂剂。当将本发明的铱配合物应用于有机发光二极管时，与传统的有机发光二极管相比，在将铱配合物化合物掺入发光层时，可以显著提高耐热性和发光性能，同时可以显著提高发光效率等。
• Solution processable red-emitting iridium (III) complex and organic electroluminescence device including the same
  申请人：LG Chem, Ltd.

  公开号：US10141523B2

  公开（公告）日：2018-11-27

  The present invention relates to a novel solution processable red-emitting iridium (III) complex. In the iridium (III) complex, a quinoline-thiophene derivative is introduced as a main ligand and a picolinic acid derivative substituted with a halogen, a substituent having electron transporting properties or a substituent having hole transporting properties is introduced as an ancillary ligand at the para-position relative to the nitrogen atom of picolinic acid. The iridium (III) complex is a red phosphorescent compound that is highly electrically stable, exhibits excellent luminescent properties and high luminance, and has high color purity. In addition, the iridium (III) complex has improved solubility in organic solvents and good resistance to heat, ensuring excellent interfacial properties with electrodes. Therefore, the iridium (III) complex is useful as a light emitting material for an organic electroluminescence device. The present invention also relates to an organic electroluminescence device including the iridium (III) complex.

  本发明涉及一种新型可溶液加工的红色发光铱（III）络合物。在铱 (III) 复合物中，引入了喹啉-噻吩衍生物作为主配体，并在相对于吡啶甲酸氮原子的对位上引入了被卤素、具有电子传输特性的取代基或具有空穴传输特性的取代基取代的吡啶甲酸衍生物作为辅助配体。铱（III）配合物是一种红色磷光化合物，具有高度的电稳定性、优异的发光特性和高亮度，并且颜色纯度高。此外，铱（III）络合物在有机溶剂中的溶解性更好，耐热性也很好，从而确保了与电极的良好界面性能。因此，铱（III）络合物可用作有机电致发光器件的发光材料。本发明还涉及一种包括铱（III）络合物的有机电致发光装置。
• POLYMERE LICHT-EMITTIERENDE DIODE UND VERFAHREN ZU DEREN HERSTELLUNG
  申请人：Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

  公开号：EP2193692B1

  公开（公告）日：2016-11-09
• NOVEL SOLUTION PROCESSABLE RED-EMITTING IRIDIUM (III) COMPLEX AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME
  申请人：PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

  公开号：US20160308148A1

  公开（公告）日：2016-10-20

  The present invention relates to a novel solution processable red-emitting iridium (III) complex. In the iridium (III) complex, a quinoline-thiophene derivative is introduced as a main ligand and a picolinic acid derivative substituted with a halogen, a substituent having electron transporting properties or a substituent having hole transporting properties is introduced as an ancillary ligand at the para-position relative to the nitrogen atom of picolinic acid. The iridium (III) complex is a red phosphorescent compound that is highly electrically stable, exhibits excellent luminescent properties and high luminance, and has high color purity. In addition, the iridium (III) complex has improved solubility in organic solvents and good resistance to heat, ensuring excellent interfacial properties with electrodes. Therefore, the iridium (III) complex is useful as a light emitting material for an organic electroluminescence device. The present invention also relates to an organic electroluminescence device including the iridium (III) complex.
• US8232549B2
  申请人：——

  公开号：US8232549B2

  公开（公告）日：2012-07-31