Custodiol | 674309-46-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Custodiol
• 英文别名: (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid;(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid;2-oxopentanedioic acid
• CAS: 674309-46-7
• 化学式: C22H27N5O9
• 分子量: 505.5
• InChiKey: ZWGNFOFTMJGWBF-VZSHSMSCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.01
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  263
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• [EN] CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS<br/>[FR] COMPOSÉS DE NORBORNÉNONE LIBÉRANT DU MONOXYDE DE CARBONE
  申请人：SAMMUT IVAN ANDREW

  公开号：WO2017095237A1

  公开（公告）日：2017-06-08

  The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

  本发明提供了在生理条件或pH触发下能够释放一氧化碳的有机化合物，以及将这种化合物用于调节细胞、组织或器官，例如，在移植事件中保护免受缺血性损伤的使用方法。
• INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT
  申请人：Kim Soon Ha

  公开号：US20100291533A1

  公开（公告）日：2010-11-18

  The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.

  本发明涉及一种用于保存细胞、组织和器官的组合物，其中包括作为活性成分的式（1）的吲哚和吲唑化合物，或其药用可接受的盐或异构体，对于预防由冷藏、移植手术或移植后再灌注引起的器官、分离的细胞系统或组织的损伤具有有效性；一种保存方法；以及该组合物的制备方法。
• [EN] LIPOPHILIC DOPAMINE DERIVATIVES AND THEIR USE<br/>[FR] DÉRIVÉS DE DOPAMINE LIPOPHILES ET LEUR UTILISATION
  申请人：NOVALIQ GMBH

  公开号：WO2013034457A1

  公开（公告）日：2013-03-14

  The invention provides novel lipophilic dopamine derivatives with improved stability and physiological half-life. The compounds may be used for organ and tissue preservation during storage and transport, or in the pre-treatment of organ and tissue donor or recipients. Moreover, they may be used as therapeutic agents for the prevention or treatment of ischaemia-related pathological conditions.

  本发明提供了一种新型的亲脂性多巴胺衍生物，具有改善稳定性和生理半衰期的特点。这些化合物可用于在储存和运输期间进行器官和组织保护，或用于器官和组织供体或受体的预处理。此外，它们可以用作治疗剂，用于预防或治疗缺血相关的病理状况。
• LIPOPHILIC DOPAMINE DERIVATIVES AND THEIR USE
  申请人：NOVALIQ GMBH

  公开号：US20140221485A1

  公开（公告）日：2014-08-07

  The invention provides novel lipophilic dopamine derivatives with improved stability and physiological half-life. The compounds may be used for organ and tissue preservation during storage and transport, or in the pre-treatment of organ and tissue donor or recipients. Moreover, they may be used as therapeutic agents for the prevention or treatment of ischaemia-related pathological conditions.

  本发明提供了一种新型的亲脂性多巴胺衍生物，其稳定性和生理半衰期得到了改善。这些化合物可用于在储存和运输期间进行器官和组织保护，或在器官和组织供体或受体的预处理中使用。此外，它们可以用作治疗药物，用于预防或治疗缺血相关的病理状况。
• ORGAN FUNCTION MAINTAINING AND AMELIORATING SOLUTION
  申请人：National Universiy Corporation Tokyo Medical and Dental University

  公开号：EP1856973A1

  公开（公告）日：2007-11-21

  It is intended to provide an organ function maintaining or ameliorating solution, which is effective for suppressing the depression of an organ provided for transplantation and an organ preservation method using the organ function maintaining or ameliorating solution. The present invention relates to an organ function maintaining or ameliorating solution for maintaining or ameliorating the functions of an organ provided for organ transplantation, comprising a pharmacologically active substance comprising glycyrrhizic acid, glycyrrhetinic acid or a pharmacologically acceptable salt or derivative thereof in an organ preservation solution. The present invention also relates to a method of preserving an organ for organ transplantation comprising perfusing the organ function maintaining or ameliorating solution to the organ isolated from the donor to cause ischemia and immersing the organ in the organ function maintaining or ameliorating solution during the time until the organ is transplanted into a recipient.

  本发明旨在提供一种器官功能维持或改善溶液，该溶液可有效抑制用于移植的器官的抑郁，并提供一种使用该器官功能维持或改善溶液的器官保存方法。 本发明涉及一种用于维持或改善供器官移植的器官功能的器官功能维持或改善溶液，该溶液包括在器官保存溶液中的一种药理活性物质，该物质包括甘草酸、甘草次酸或其药理上可接受的盐或衍生物。本发明还涉及一种为器官移植保存器官的方法，包括向从供体分离出来的器官灌注器官功能维持或改善溶液以造成缺血，并在器官移植到受体之前的时间内将器官浸泡在器官功能维持或改善溶液中。