DL-Glutamic acid, N-(dicarboxymethyl)- | 112174-44-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-Glutamic acid, N-(dicarboxymethyl)-
• 英文别名: 2-(dicarboxymethylamino)pentanedioic acid
• CAS: 112174-44-4
• 化学式: C₈H₁₁NO₈
• 分子量: 249.17
• InChiKey: DIWZKTYQKVKILN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  161
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Compositions and Methods for Fermentation of Biomass
  申请人：Parekh Sarad

  公开号：US20100268000A1

  公开（公告）日：2010-10-21

  In one aspect, this invention relates to production of useful fermentation end-products from biomass through simultaneous hydrolysis and fermentation by a microorganism, such as Clostridium phytofermentans . The invention also relates to the development of a process for efficient pretreatment and conversion of lignocellulosic biomass to end-products with high conversion efficiency (yield). In another aspect, methods for producing a fermentation end-product by fermenting hexose (C6) and pentose (C5) sugars with a microorganism, such as Clostridium phytofermentans are disclosed herein.

  在一个方面，这项发明涉及通过微生物（如植物发酵槽菌）的同时水解和发酵，从生物质中生产有用的发酵终产物。该发明还涉及开发一种高效预处理和转化木质纤维素生物质为高转化效率（产率）的终产物的过程。在另一个方面，本文介绍了利用微生物（如植物发酵槽菌）发酵己糖（C6）和戊糖（C5）糖产生发酵终产物的方法。
• [EN] SYNTHESIS OF ALPHA-TOCOPHEROLQUINONE DERIVATIVES, AND METHODS OF USING THE SAME<br/>[FR] SYNTHÈSE DE DÉRIVÉS D'ALPHA-TOCOPHÉROLQUINONE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：PENWEST PHARMACEUTICALS CO

  公开号：WO2011112679A1

  公开（公告）日：2011-09-15

  The present invention is directed to a method of synthesizing a compound of Formula I: the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of I (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/aipha-tocopherol is 1.6 to 4.

  本发明涉及一种合成式I化合物的方法：该方法包括将α-生育酚与金属盐氧化剂氧化，形成式I化合物，其中金属盐氧化剂/α-生育酚的化学计量比(mol/mol)为1.6至4。本发明还涉及一种合成式I化合物的方法，该方法包括：(a)在碱的存在下水解α-生育酰乙酸酯；(b)中和(a)的水解，从而形成α-生育酚；(c)将I(b)的α-生育酚与金属盐氧化剂氧化，形成式I化合物，其中金属盐氧化剂/α-生育酚的化学计量比(mol/mol)为1.6至4。
• [EN] QUINONES AND PROCESS OF OBTAINING SAME<br/>[FR] QUINONES ET PROCÉDÉ D'OBTENTION ASSOCIÉ
  申请人：BASF SE

  公开号：WO2019158514A1

  公开（公告）日：2019-08-22

  Disclosed is a process for the oxidation of at least one chroman (C1) in a solvent mixture comprising at least two solvents or in a C-bearing solvent, with a gaseous compound comprising, essentially consisting of, or consisting of oxygen in the presence of a copper catalyst, said copper catalyst exhibiting the oxidation state (+1) or (+2). A further part of the disclosure is a composition comprising at least one chroman (C1) and/or at least one quinone (C30), a solvent mixture comprising at least two solvents or a C-bearing solvent, a copper catalyst, said copper catalyst exhibiting the oxidation state (+1) or (+2) and a gaseous compound comprising, essentially consisting or consisting of oxygen. A quinone preparation and a process of making same is also part of the invention.

  本文揭示了一种在至少两种溶剂组成的溶剂混合物中，或者在含碳溶剂中，利用氧气气态化合物在铜催化剂存在下氧化至少一种色基酚（C1）的过程，所述铜催化剂呈现氧化态（+1）或（+2）。本文的另一部分揭示了一种组合物，包括至少一种色基酚（C1）和/或至少一种醌（C30），至少两种溶剂组成的溶剂混合物或含碳溶剂，铜催化剂，所述铜催化剂呈现氧化态（+1）或（+2），以及包含氧气的气态化合物。醌制备方法及其制备过程也是本发明的一部分。
• SYNTHESIS OF ALPHA-TOCOPHEROLQUINONE DERIVATIVES, AND METHODS OF USING THE SAME
  申请人：PAISLEY Steven D.

  公开号：US20110263720A1

  公开（公告）日：2011-10-27

  The present invention is directed to a method of synthesizing a compound of Formula I: the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4.

  本发明涉及一种合成化合物I的方法：该方法包括使用金属盐氧化剂将α-生育酚氧化成化合物I，其中金属盐氧化剂/α-生育酚的化学计量比（mol/mol）为1.6至4。本发明还涉及一种合成化合物I的方法，该方法包括：（a）在碱的存在下水解α-生育酰醋酸酯；（b）中和步骤（a）的水解反应，从而形成α-生育酚；以及（c）使用金属盐氧化剂将步骤（b）中的α-生育酚氧化成化合物I，其中金属盐氧化剂/α-生育酚的化学计量比（mol/mol）为1.6至4。
• MUCOSAL DELIVERY COMPOSITIONS COMPRISING A PEPTIDE COMPLEXED WITH A CROWN COMPOUND AND/OR A COUNTER ION
  申请人：Botti Paolo

  公开号：US20120302502A1

  公开（公告）日：2012-11-29

  Compositions and methods are provided for mucosal delivery of peptides. The compositions include a stably hydrated peptide active agent complexed with a crown compound and/or a counter ion solubilized in a non-aqueous hydrophobic vehicle at a pH different from the pI of the peptide active agent. The methods include administering to a subject an effective amount of a composition of the disclosure. Other aspects include methods for the manufacture of the compositions of the disclosure. Also provided are compositions and kits that find use in practicing embodiments of the disclosure. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions.

  本发明提供了一种黏膜递送肽的组合物和方法。该组合物包括稳定水合的肽活性剂与皇冠化合物和/或反离子络合在非水性疏水载体中，pH不同于肽活性剂的等电点。该方法包括向受试者施用本公开的组合物的有效剂量。其他方面包括制造本公开组合物的方法。本发明还提供了在实施本公开实施例中使用的组合物和工具包。所述方法和组合物在各种应用中使用，包括治疗各种不同的疾病状况。