N-(4-ethoxy-phenyl)-[1,3,5]triazine-2,4-diamine | 91333-18-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(4-ethoxy-phenyl)-[1,3,5]triazine-2,4-diamine
• 英文别名: N²-(4-ethoxy-phenyl)-[1,3,5]triazine-2,4-diyldiamine；N²-(4-Aethoxy-phenyl)-[1,3,5]triazin-2,4-diyldiamin；6-(4-Aethoxy-anilino)-4-amino-1.3.5-triazin；N-(4-ethoxyphenyl)-1,3,5-triazine-2,4-diamine；2-N-(4-ethoxyphenyl)-1,3,5-triazine-2,4-diamine
• CAS: 91333-18-5
• 化学式: C₁₁H₁₃N₅O
• mdl: MFCD07157546
• 分子量: 231.257
• InChiKey: ZWXHFGCPMUAGGL-UHFFFAOYSA-N

物化性质

• 熔点：
  209-210 °C
• 沸点：
  468.1±47.0 °C(Predicted)
• 密度：
  1.299±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  86
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为产物：
  描述：

  amino-p-phenetidino-[1,3,5]triazine-2-carboxylic acid ethyl ester 在 盐酸 、 氢氧化钾 作用下， 生成 N-(4-ethoxy-phenyl)-[1,3,5]triazine-2,4-diamine
  参考文献：
  名称：

  Age-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status

  摘要：

  Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its. possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats.

  DOI：

  10.1093/gerona/56.10.b426

文献信息

• Papini, Gazzetta Chimica Italiana, 1950, vol. 80, p. 844,848
  作者：Papini

  DOI：——

  日期：——
• Clauder; Bulcsu, Magyar Kemiai Folyoirat, 1951, vol. 57, p. 68,71
  作者：Clauder、Bulcsu

  DOI：——

  日期：——
• Age-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status
  作者：B. S. Baek、J. W. Kim、J. H. Lee、H. J. Kwon、N. D. Kim、H. S. Kang、M. A. Yoo、B. P. Yu、H. Y. Chung

  DOI：10.1093/gerona/56.10.b426

  日期：2001.10.1

  Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its. possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats.