2-羟基-N,N-二甲基-1,1'-联苯-3-甲酰胺 | 46878-66-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基-N,N-二甲基-1,1'-联苯-3-甲酰胺
• 英文名称: N.N-Dimethyl-3-phenyl-salicylamid
• 英文别名: 2-hydroxy-N,N-dimethylbiphenyl-3-carboxamide；2-hydroxy-biphenyl-3-carboxylic acid dimethylamide；2-Hydroxy-biphenyl-3-carbonsaeure-dimethylamid；2-hydroxy-N,N-dimethyl-(1,1'-biphenyl)-3-carboxamide；Salicylamide, N,N-dimethyl-3-phenyl-；2-hydroxy-N,N-dimethyl-3-phenylbenzamide
• CAS: 46878-66-4
• 化学式: C₁₅H₁₅NO₂
• 分子量: 241.29
• InChiKey: FFHMRUWVKUUENH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  3-苯基水杨酸	3-phenylsalicylic acid	304-06-3	C13H10O3	214.221
  ——	3-Phenylsalicylsaeurephenylester	3072-89-7	C19H14O3	290.318

反应信息

• 作为反应物：
  描述：

  2-羟基-N,N-二甲基-1,1'-联苯-3-甲酰胺 、 乙酰氯 生成 2-acetoxy-biphenyl-3-carboxylic acid dimethylamide
  参考文献：
  名称：

  Specific immune response to parietaria judaica plant profilin: a low t cell proliferative response supports high ige and skin prick test

  摘要：

  Background: allergic disease caused by Parietaria judaica (Pj) has been widely documented in Mediterranean area. Profilins have been identified as widely distributed allergenic proteins. The role of Pj profilin in specific immune response in Pj-sensitized patients is unknown. Methods: skin prick test and determination of specific and total IgE levels in serum were performed in all patients (n = 28) and non-allergic controls (n = 18). Peripheral blood mononuclear cells (PBMC) were isolated from both groups and stimulated with crude extract or highly purified Pj profilin. The production of type I and type II cytokines was determined by specific and polyclonal stimuli in patients and controls. T-cell lines specific to Pj profilin were established and cross-reactivity with another highly purified profilin from Phleum pratense (Phl p) was evaluated. Results: Pj profilin-sensitized patients showed a small but significantly increased in T-cell proliferative response to this profilin compared with non-atopic controls. The production of interleukin (IL)-4 and interferon (IFN)-γ in response to the specific stimulus was undetectable. However, the production of IL-4 in response to a polyclonal stimulus [phytohemagglutinin (PHA)] was significantly higher in atopic patients than in controls. The T-cell response did not correlate with the magnitude of response to skin prick tests with Pj profilin or with Pj-specific serum IgE levels. In addition, the production of IL-4 in response to a polyclonal stimulus (PHA) did not correlate with the individual skin prick tests to Pj profilin or with Pj-specific IgE levels in serum. The T-cell lines tested showed no cross-reactivity with Phl p profilin. Conclusions: our results suggest that Pj profilin is partly responsible for the T-cell-mediated response in patients allergic to Pj. The high skin reactivity to Pj profilin is these patients was accompanied by a small increase in the T-cell response to this profilin. The response was highly specific since Pj profilin specific T-cell lines showed no cross-reactivity with a highly homologous profilin from Phl p. The lack of correlation between the proliferative T-cell response and polyclonal IL-4 production with allergen-specific serum IgE and skin reactivity probably indicates that some of the responding T-cells may be involved in immune reactions other than those supporting IgE production.

  DOI：

  10.1016/s0301-0546(02)79092-7
• 作为产物：
  描述：

  3-苯基水杨酸 在 三氯氧磷 作用下， 生成 2-羟基-N,N-二甲基-1,1'-联苯-3-甲酰胺
  参考文献：
  名称：

  Nakajima et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 1211

  摘要：

  DOI：

文献信息

• A Mild Benzannulation through Directed Cycloaddition Reactions
  作者：James D. Kirkham、Roger J. Butlin、Joseph P. A. Harrity

  DOI：10.1002/anie.201200917

  日期：2012.6.25

  Simple as ABC: Alkynyl borane cycloadditions can be substrate‐directed to assemble aromatic difluoroboranes within an extremely mild and efficient reaction manifold compared to that of traditional methods (see scheme). The aromatic boranes are readily transformed into a range of useful products.

  与ABC一样简单：与传统方法相比，炔基硼烷环加成物可在非常温和有效的反应歧管中进行底物导向，以组装芳族二氟硼烷（请参阅方案）。芳香族硼烷很容易转化为一系列有用的产品。
• Nakajima et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 1211
  作者：Nakajima et al.

  DOI：——

  日期：——
• Specific immune response to parietaria judaica plant profilin: a low t cell proliferative response supports high ige and skin prick test
  作者：D. Benítez、P. García-Ortega、C. Picado、J. Milà、J. Vives、J. Martínez、R. Vilella

  DOI：10.1016/s0301-0546(02)79092-7

  日期：2002.1

  Background: allergic disease caused by Parietaria judaica (Pj) has been widely documented in Mediterranean area. Profilins have been identified as widely distributed allergenic proteins. The role of Pj profilin in specific immune response in Pj-sensitized patients is unknown. Methods: skin prick test and determination of specific and total IgE levels in serum were performed in all patients (n = 28) and non-allergic controls (n = 18). Peripheral blood mononuclear cells (PBMC) were isolated from both groups and stimulated with crude extract or highly purified Pj profilin. The production of type I and type II cytokines was determined by specific and polyclonal stimuli in patients and controls. T-cell lines specific to Pj profilin were established and cross-reactivity with another highly purified profilin from Phleum pratense (Phl p) was evaluated. Results: Pj profilin-sensitized patients showed a small but significantly increased in T-cell proliferative response to this profilin compared with non-atopic controls. The production of interleukin (IL)-4 and interferon (IFN)-γ in response to the specific stimulus was undetectable. However, the production of IL-4 in response to a polyclonal stimulus [phytohemagglutinin (PHA)] was significantly higher in atopic patients than in controls. The T-cell response did not correlate with the magnitude of response to skin prick tests with Pj profilin or with Pj-specific serum IgE levels. In addition, the production of IL-4 in response to a polyclonal stimulus (PHA) did not correlate with the individual skin prick tests to Pj profilin or with Pj-specific IgE levels in serum. The T-cell lines tested showed no cross-reactivity with Phl p profilin. Conclusions: our results suggest that Pj profilin is partly responsible for the T-cell-mediated response in patients allergic to Pj. The high skin reactivity to Pj profilin is these patients was accompanied by a small increase in the T-cell response to this profilin. The response was highly specific since Pj profilin specific T-cell lines showed no cross-reactivity with a highly homologous profilin from Phl p. The lack of correlation between the proliferative T-cell response and polyclonal IL-4 production with allergen-specific serum IgE and skin reactivity probably indicates that some of the responding T-cells may be involved in immune reactions other than those supporting IgE production.