Racemoid nor-poon essence A | 679838-31-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: Racemoid nor-poon essence A
• 英文别名: (16R,18S)-18-hydroxy-10,10,16-trimethyl-6-propyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaen-4-one
• CAS: 679838-31-4
• 化学式: C₂₁H₂₄O₅
• 分子量: 356.419
• InChiKey: PKRFUEHGRHZIHD-RISCZKNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以86%的产率得到Racemoid nor-poon essence A
  参考文献：
  名称：

  Chemical resolution of (±)-calanolide A, (±)-cordatolide A and their 11-demethyl analogues

  摘要：

  The chemical resolution of (+/-)-calanolide A and (+/-)-cordatolide A into their corresponding optically active enantiomers is described. Their inhibitory activities against HIV-1 are tested in vitro. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.008

文献信息

• PREPARATION OF A TRANS-CALANOLIDE KETONE INTERMEDIATE AND CHIRAL SEPARATION OF CALANOLIDE ALCOHOLS TO GIVE RACEMIC CALANOLIDE A
  申请人：Dow Global Technologies Inc.

  公开号：EP1597263B1

  公开（公告）日：2008-04-23
• PHARMACEUTICAL COMPOSITIONS FOR CALANOLIDES, THEIR DERIVATIVES AND ANALOGUES, AND PROCESS FOR PRODUCING THE SAME
  申请人：Craun Research Sdn Bhd

  公开号：EP2618815B1

  公开（公告）日：2017-11-15
• Chemical resolution of (±)-calanolide A, (±)-cordatolide A and their 11-demethyl analogues
  作者：Tao Ma、Qi Gao、Zhiwei Chen、Lin Wang、Gang Liu

  DOI：10.1016/j.bmcl.2007.12.008

  日期：2008.2

  The chemical resolution of (+/-)-calanolide A and (+/-)-cordatolide A into their corresponding optically active enantiomers is described. Their inhibitory activities against HIV-1 are tested in vitro. (C) 2007 Elsevier Ltd. All rights reserved.