(1R,4S,5S,6S)-4-[(2-amino-4-methylsulfanylbutanoyl)amino]-2,2-dioxo-2lambda6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1R,4S,5S,6S)-4-[(2-amino-4-methylsulfanylbutanoyl)amino]-2,2-dioxo-2lambda6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
• 英文别名: (1R,4S,5S,6S)-4-[(2-amino-4-methylsulfanylbutanoyl)amino]-2,2-dioxo-2λ6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
• 化学式: C₁₂H₁₈N₂O₇S₂
• 分子量: 366.4
• InChiKey: VOYCNOJFAJAILW-LWDQJBINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  198
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS
  申请人：The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone

  公开号：EP3039126B1

  公开（公告）日：2019-10-09
• COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20220047593A1

  公开（公告）日：2022-02-17

  The present invention relates to combinations comprising a positive allosteric modulator (“PAM”) of metabotropic glutamatergic receptor subtype 2 (“mGluR2”) or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic receptor subtype 2 compound or a pharmaceutically acceptable salt or a solvate thereof, and a synaptic vesicle protein 2A (“SV2A”) ligand.
• METHODS FOR TREATING DISORDERS ASSOCIATED WITH SLEEP SPINDLE DEFICITS
  申请人：The Broad Institute, Inc.

  公开号：US20220211658A1

  公开（公告）日：2022-07-07

  Provided herein are methods for treating a disorder associated with a sleep spindle deficit using a group II metabotropic glutamate receptor modulator.
• US7371872B2
  申请人：——

  公开号：US7371872B2

  公开（公告）日：2008-05-13