2-羟基丙基庚酸酯 | 7249-54-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-羟基丙基庚酸酯
• 英文名称: 2-hydroxypropyl heptanoate
• 英文别名: 1-Hectanoyloxy-2-propanol；1-Heptanoyloxy-2-propanol
• CAS: 7249-54-9
• 化学式: C₁₀H₂₀O₃
• 分子量: 188.267
• InChiKey: DZOOROWXIIPFGA-UHFFFAOYSA-N

物化性质

• LogP：
  2.378 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  光气 、 2-羟基丙基庚酸酯 生成 Bis-<2-heptanoyloxy-1-methylethyl>-peroxydicarbonat
  参考文献：
  名称：

  Fomin,V.A. et al., Journal of Organic Chemistry USSR (English Translation), 1972, vol. 8, p. 2097 - 2100

  摘要：

  DOI：
• 作为产物：
  描述：

  2-己基-4-甲基-1,3-二氧戊环 以85%的产率得到
  参考文献：
  名称：

  KURAMSHIN, EH. M.;GUMEROVA, V. K.;DYACHENKO, V. A.;KULAK, L. G.;MOLYAVKO,+, ZH. OBSHCH. XIMII, 58,(1988) N 5, 1069-1075

  摘要：

  DOI：

文献信息

• UV ABSORBER FORMULATIONS
  申请人：Acker Stephanie

  公开号：US20100111884A1

  公开（公告）日：2010-05-06

  Disclosed is a UV filter composition comprising (a) an organic UV absorber of formula (1), wherein R 1 and R 2 , independently of one another, are C 3 -C 18 alkyl; C 2 -C 18 alkenyl; a radical of the formula —CH 2 —CH(OH)—CH 2 —O-T 1 ; or R 1 and R 2 are a radical of the formula (4a); R 7 is a direct bond; a straight-chain or branched C 1 -C 4 alkylene radical or a radical of the formula (I) or (II); R 8 , R 9 and R 10 , independently of one another, are C 1 -C 18 alkyl; C 1 -C 18 alkoxy or a radical of the formula (III); R 11 is C 1 -C 5 alkyl; m 1 is a number from 1 to 4; p 1 is 0; or a number from 1 to 5; A 1 is a radical of the formula (1b), (1c) or (1d); R 3 is hydrogen; C 1 -C 10 alkyl; —(CH 2 CHR 5 —O)n 1 -T 2 ; or —CH 2 —CH(—OH)—CH 2 —O-T 2 ; R 4 is hydrogen; M; C 1 -C 5 alkyl; or —(CH 2 )m 2 —O-T 3 ; R 5 is hydrogen; or methyl; T 1 , T 2 and T 3 independently from each other are hydrogen; or C 1 -C 18 alkyl; Q 1 is C 1 -C 18 alkyl, M is a metal cation; m 2 is 1 to 4; and n 1 is 1-16, (b) dimethyl capramide, (c) a cosmetically acceptable carrier; and water.

  本发明公开了一种紫外线过滤组合物，包括（a）式（1）的有机紫外线吸收剂，其中R1和R2独立地是C3-C18烷基；C2-C18烯基；式—CH2—CH（OH）—CH2—O-T1的基团；或者R1和R2是式（4a）的基团；R7是直链或支链C1-C4烷基、式（I）或（II）的基团；R8、R9和R10独立地是C1-C18烷基、C1-C18烷氧基或式（III）的基团；R11是C1-C5烷基；m1是1至4的数字；p1是0或1至5的数字；A1是式（1b）、（1c）或（1d）的基团；R3是氢、C1-C10烷基、式—（CH2CHR5—O）n1-T2或式—CH2—CH（—OH）—CH2—O-T2；R4是氢、M、C1-C5烷基或式—（CH2）m2—O-T3；R5是氢或甲基；T1、T2和T3互相独立地是氢或C1-C18烷基；Q1是C1-C18烷基，M是金属阳离子；m2是1至4的数字；n1是1-16，（b）二甲基辛酰胺，（c）化妆品可接受载体；和水。
• [EN] TOPICAL COMPOSITIONS<br/>[FR] COMPOSITIONS TOPIQUES
  申请人：DSM IP ASSETS BV

  公开号：WO2021047905A1

  公开（公告）日：2021-03-18

  The present invention relates cosmetic compositions comprising a mixture of 1,4-di(benzoxazol-2'-yl)benzene and a preservative as well as to the use of said mixture as antimicrobial agent.

  本发明涉及一种化妆品组合物，包括1,4-二(苯并噁唑-2'-基)苯和一种防腐剂的混合物，以及所述混合物作为抗微生物剂的用途。
• TOPICAL COMPOSITIONS WITH PRESERVATION SYSTEM
  申请人：DSM IP Assets B.V.

  公开号：EP3735958A1

  公开（公告）日：2020-11-11

  The present invention relates to topical compositions comprising a mixture of phytantriol and a C4-6alkyl glycerine as well as to the use of said mixture for the reduction and/ or prevention of microbial growth.

  本发明涉及由植物三醇和 C4-6 烷基甘油混合物组成的外用组合物，以及使用所述混合物减少和/或防止微生物生长。
• Cosmetic composition with a volumizing effect
  申请人：L'OREAL

  公开号：US10220223B2

  公开（公告）日：2019-03-05

  A cosmetic composition for caring for and/or making up the skin and/or the lips, containing, in a physiologically acceptable medium, includes at least: one active agent comprising at least one glycol with a C4-C16 hydrocarbon-based chain and/or a hydroxylated ester resulting from the esterification of polyol and/or of C4-C16 carboxylic acid(s), and one additional agent chosen from essential oils, agents for promoting capillary circulation and temperature regulators, and mixtures thereof.

  一种用于护理和/或妆扮皮肤和/或嘴唇的化妆品组合物，在生理上可接受的介质中，至少包括 一种活性剂，包含至少一种具有 C4-C16 碳氢链的乙二醇和/或多元醇和/或 C4-C16 羧酸酯化产生的羟化酯，以及 一种附加剂，选自精油、促进毛细管循环剂和温度调节剂及其混合物。
• Oral composition of celecoxib for treatment of pain
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：US10376527B2

  公开（公告）日：2019-08-13

  The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.

  本发明涉及一种稳定的塞来昔布或其药学上可接受的盐的口服液体药物组合物。本发明所述组合物中的塞来昔布在pH值为2.0、温度为37℃±0.5℃、转速为50转/分钟的空腹模拟胃液（FaSSGF）中至少搅拌60分钟后不会出现任何沉淀。它还涉及上述塞来昔布组合物的制备过程和使用方法。