2-methoxy-propane-1,2,3-tricarboxylic acid | 86406-84-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methoxy-propane-1,2,3-tricarboxylic acid
• 英文别名: 2-Methoxy-propan-1,2,3-tricarbonsaeure；β-Methoxy-tricarballylsaeure；Methylaethercitronensaeure；Methylocitronensaeure；methyl ether of citric acid；2-Methoxypropane-1,2,3-tricarboxylic acid
• CAS: 86406-84-0
• 化学式: C₇H₁₀O₇
• 分子量: 206.152
• InChiKey: PCQLOXBORLRAOT-UHFFFAOYSA-N

物化性质

• 沸点：
  305.1±42.0 °C(Predicted)
• 密度：
  1.534±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  柠檬酸三甲酯 在 盐酸 、 silver(l) oxide 作用下， 生成 2-methoxy-propane-1,2,3-tricarboxylic acid
  参考文献：
  名称：

  Anschuetz, Justus Liebigs Annalen der Chemie, 1903, vol. 327, p. 228

  摘要：

  DOI：

文献信息

• [EN] PANTETHENOYLCYSTEINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PANTÉTHÉNOYLCYSTÉINE ET LEURS UTILISATIONS
  申请人：COMET THERAPEUTICS INC

  公开号：WO2020198573A1

  公开（公告）日：2020-10-01

  The present disclosure relates to compounds of Formula (I) or (II): (Formulae (I), (II)), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

  本公开涉及式(I)或(II)的化合物：(式(I)，(II))，以及其药用可接受的盐或溶剂化合物。本公开还涉及包含这些化合物的药物组合物，以及这些化合物和药物组合物的治疗和诊断用途。
• Amphiphilic Long-chain Citric Acid Ethers
  作者：Daniel Meißner、Peter Jutzi

  DOI：10.1515/znb-2009-0620

  日期：2009.6.1

  The etherification of the hydroxyl group of citric acid with saturated and unsaturated long-chain alkyl groups is described. This is a new approach to polydentate acids which may serve as ligands for metal or metal oxide nanoparticles. For this purpose we developed a synthetic route to long-chain ω-unsaturated alcohols and their triflate derivatives.

  描述了柠檬酸羟基与饱和和不饱和长链烷基基团的醚化反应。这是一种新的制备多齿酸的方法，可以作为金属或金属氧化物纳米颗粒的配体。为此，我们开发了一种合成长链ω-不饱和醇及其三氟甲烷基衍生物的方法。
• [EN] BLOCK COPOLYMERS AND THEIR CONJUGATES OR COMPLEXES WITH OLIGONUCLEOTIDES<br/>[FR] COPOLYMÈRES SÉQUENCÉS ET LEUR CONJUGUÉS OU COMPLEXES AVEC DES OLIGONUCLÉOTIDES
  申请人：PHASERX INC

  公开号：WO2015017519A1

  公开（公告）日：2015-02-05

  Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

  本文描述了嵌段共聚物以及制备和利用这种共聚物的方法。所述的嵌段共聚物破坏细胞膜，包括细胞外膜、细胞内膜、囊泡、细胞器、内体、脂质体或红细胞。在某些情况下，该嵌段共聚物会破坏膜并进入细胞内环境。在具体示例中，该嵌段共聚物具有内体溶解作用，并能够将寡核苷酸（例如mRNA）传递到细胞中。还公开了包含嵌段共聚物和寡核苷酸（例如mRNA）的组合物。
• [EN] HETEROARYL CARBONITRILES FOR THE TREATMENT OF DISEASE<br/>[FR] CARBONITRILES HÉTÉROARYLES POUR LE TRAITEMENT DE MALADIE
  申请人：OPKO HEALTH INC

  公开号：WO2017011445A1

  公开（公告）日：2017-01-19

  The invention relates to pharmaceutical compositions and dosage forms having a piperidine carbonitrile as an active ingredient for the treatment of various diseases and conditions. The preferred compound is a crystalline form of a trifluoromethylphenylalkoxyalkylheteroarylaryl piperidine carbonitrile. Methods of treating diseases and conditions are disclosed as well as processes to make crystalline forms of the above compounds.

  本发明涉及一种含有哌啶基碳腈作为活性成分的制药组合物和剂型，用于治疗各种疾病和病况。首选化合物是三氟甲基苯基烷氧基烷基杂环芳基哌啶碳腈的晶体形式。公开了治疗疾病和病况的方法以及制备上述化合物的晶体形式的方法。
• Enzymic agent for washing, degreasing and water reconditioning
  申请人：TUKOVY PRUMYSL, KONCERN

  公开号：EP0355228A1

  公开（公告）日：1990-02-28

  The detergent is based on an enzyme complex, and particularly on lipases and oxidoreductases. A substantially lower contents of surfactants and chelatizing components positively influences the effects of enzyme constituents on all of the basic dirt types, except for pigments, and promotes the environmental protection. Apart from this, the washing ability of this detergent even if used at low temperatures has its significance in power econonmy.

  这种洗涤剂以复合酶为基础，特别是以脂肪酶和氧化还原酶为基础。表面活性剂和螯合成分的含量大大降低，这对酶成分对除颜料以外的所有基本污垢的作用都有积极影响，并促进了环境保护。此外，即使在低温条件下使用，这种洗涤剂的洗涤能力在节能方面也具有重要意义。