2-羟基二十三烷酸 | 26632-12-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-羟基二十三烷酸
• 英文名称: 2-Hydroxytricosanoic acid
• CAS: 26632-12-2；2718-37-8
• 化学式: C₂₃H₄₆O₃
• 分子量: 370.6
• InChiKey: JZWLIRVAYJRWLN-UHFFFAOYSA-N

物化性质

• 沸点：
  496.6±18.0 °C(Predicted)
• 密度：
  0.924±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿:甲醇(5:1):可溶

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  26
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Lipids That Increase Insulin Sensitivity And Methods Of Using The Same
  申请人：BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

  公开号：US20160221925A1

  公开（公告）日：2016-08-04

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders—including diabetes-related disorders, Metabolic Syndrome, polycystic ovarian syndrome, cancer, and inflammatory disorders—using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  该发明提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的酯脂类分子）以及用于诊断和治疗各种疾病的方法，包括与糖尿病相关的疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病等；以及筛选可用于治疗这些疾病和/或调节FAHFA水平、FAHFA介导信号传导和FAHFA介导生物效应的其他化合物的方法。
• [EN] LIPIDS THAT INCREASE INSULIN SENSITIVITY AND METHODS OF USING THE SAME<br/>[FR] LIPIDES AUGMENTANT LA SENSIBILITÉ À L'INSULINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BETH ISREAL DEACONESS MEDICAL CT INC

  公开号：WO2013166431A1

  公开（公告）日：2013-11-07

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders- including diabetes-related disorders, Metabolic Syndrome, polycyctic ovarian syndrome, cancer, and inflammatory disorders— using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  这项发明提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的酯脂类分子）以及用于治疗各种疾病的诊断和治疗方法，包括与糖尿病相关的疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病，以及使用它们的方法；以及筛选对这些疾病有用或调节FAHFA水平、FAHFA介导的信号传导和FAHFA介导的生物效应的其他化合物的方法。
• COMPOSITIONS COMPRISING POLYMERS PREPARED FROM 2-HYDROXYALKYL ACIDS
  申请人：Moeller Michael

  公开号：US20130131190A1

  公开（公告）日：2013-05-23

  Described herein are compositions comprising polymers prepared by melt polycondensation of 2-hydroxyalkyl acids. Methods of making and using the compositions are also disclosed.

  本文描述了由2-羟基烷基酸熔融缩聚制备的聚合物组成物。还公开了制备和使用该组成物的方法。
• A lipid composition containing liquid crystal phase
  申请人：Takasago International Corporation

  公开号：EP0875232A1

  公开（公告）日：1998-11-04

  The composition comprises a 2-acetaminoalkane-1, 3-diol or its optical isomer having the formula: in which R1 signifies a linear alkyl group having 9 to 17 carbon atoms; a 2-acylaminoalkane-1, 3-diol or its optical isomer having the formula: in which R1 has the same meaning as mentioned above and R2 signifies a linear acyl group having 14 to 24 carbon atoms; as well as cholesterol, and optionally a compound chosen from the group consisting of a cholesterol derivative, a fatty acid and a derivative thereof. This composition forms a lamellar liquid crystal phase which can retain moisture. When the composition is applied to a human skin or scalp, it prevents the skin and scalp from drying-out or deterioration. The composition can thus be used as a cosmetic or pharmaceutical product.

  组合物包括 2-乙酰氨基烷-1，3-二醇或其光学异构体，其式如下 其中 R1 表示具有 9 至 17 个碳原子的直链烷基； 2-乙酰氨基烷-1，3-二醇或其光学异构体，其式如下 其中 R1 与上述含义相同，R2 表示具有 14 至 24 个碳原子的直链酰基； 胆固醇，以及可选的胆固醇衍生物、脂肪酸及其衍生物组成的化合物。这种组合物形成的片状液晶相可以保持水分。将该组合物涂在人的皮肤或头皮上，可防止皮肤和头皮干燥或变质。因此，该组合物可用作化妆品或药品。
• ELECTROCONDUCTIVE ADHESIVE
  申请人：Osaka Soda Co., Ltd.

  公开号：EP3467062A1

  公开（公告）日：2019-04-10

  Provided is an electroconductive adhesive which is less apt to suffer cracking, chipping, etc. upon sintering and gives sintered objects having excellent mechanical strength. The electroconductive adhesive comprises metallic microparticles which include a protective layer comprising one or more amines and have an average particle diameter of 30-300 nm, the amines comprising a C5-7 monoalkylamine and/or an alkoxyamine represented by the following general formula (1). NH2-R2-O-R1 (1) In the protective layer, the ratio of the C5-7 monoalkylamine and/or alkoxyamine represented by the general formula (1) to one or more amines different therefrom is in the range of 100 : 0 to 10 : 90. [In formula (1), R1 represents a C1-4 alkyl group and R2 represents a C1-4 alkylene group.]

  本发明提供了一种导电粘合剂，这种粘合剂在烧结时不易出现开裂、崩裂等现象，而且烧结物具有极佳的机械强度。这种导电粘合剂由金属微粒组成，金属微粒包括由一种或多种胺组成的保护层，其平均粒径为 30-300 纳米，胺包括 C5-7 单烷基胺和/或由以下通式（1）表示的烷氧基胺。NH2-R2-O-R1 (1) 在保护层中，通式(1)代表的 C5-7 单烷基胺和/或烷氧基胺与不同于通式(1)的一种或多种胺的比例范围为 100 : 0 至 10 : 90。式（1）中，R1 代表 C1-4 烷基，R2 代表 C1-4 亚烷基。