4-(1,2-diacetoxyethyl)benzoic acid | 1219706-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1,2-diacetoxyethyl)benzoic acid
• 英文别名: 4-(1,2-Diacetyloxyethyl)benzoic acid
• CAS: 1219706-00-9
• 化学式: C₁₃H₁₄O₆
• 分子量: 266.251
• InChiKey: QAQPCSZQMGCPRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  碘苯二乙酸 、 4-乙烯基苯甲酸 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 、 溶剂黄146 为溶剂， 反应 16.0h， 以70%的产率得到4-(1,2-diacetoxyethyl)benzoic acid
  参考文献：
  名称：

  Copper-Catalyzed Diacetoxylation of Olefins using PhI(OAc)₂ as Oxidant

  摘要：

  Copper(I) or -(II) salts with weakly coordinating anions catalyze the diacetoxylation of olefins efficiently in the presence of PhI(OAc)(2) as the oxidant under mild conditions, The reaction is effective for aryl, aryl alkyl, as well as aliphatic terminal and internal olefins forming the corresponding vicinal diacetoxy compounds in 70-85% yields and dr (syn/anti) of up to 5.2. Under these conditions, homoallylic alcohols formed the corresponding tetrahydrofuran derivatives in high yields.

  DOI：

  10.1021/ol902813m

文献信息

• Copper-Catalyzed Diacetoxylation of Olefins using PhI(OAc)₂ as Oxidant
  作者：Jayasree Seayad、Abdul Majeed Seayad、Christina L. L. Chai

  DOI：10.1021/ol902813m

  日期：2010.4.2

  Copper(I) or -(II) salts with weakly coordinating anions catalyze the diacetoxylation of olefins efficiently in the presence of PhI(OAc)(2) as the oxidant under mild conditions, The reaction is effective for aryl, aryl alkyl, as well as aliphatic terminal and internal olefins forming the corresponding vicinal diacetoxy compounds in 70-85% yields and dr (syn/anti) of up to 5.2. Under these conditions, homoallylic alcohols formed the corresponding tetrahydrofuran derivatives in high yields.