p-Tolyldiazen | 58402-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Tolyldiazen
• 英文别名: Diazene, (4-methylphenyl)-；(4-methylphenyl)diazene
• CAS: 58402-51-0；114693-47-9
• 化学式: C₇H₈N₂
• 分子量: 120.154
• InChiKey: YQFYJSJNLQCKRO-UHFFFAOYSA-N

物化性质

• 沸点：
  165.2±33.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  36.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-methylbenzenediazonium hexafluorophosphate 在 trans,trans-W(H)(CO)2(NO)(PPh3)2 、 四丁基溴化铵 作用下， 生成 p-Tolyldiazen
  参考文献：
  名称：

  Stereoselective synthesis of monosubstituted cis-aryldiazenes, NH:NR

  摘要：

  DOI：

  10.1021/ja00220a072

文献信息

• Pyridazinones for the treatment of cancer
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2955182A1

  公开（公告）日：2015-12-16

  The present invention relates to novel substituted pyrrolo- and pyrazolopyridazinones, as well as pharmaceutical compositions containing at least one of these substituted pyrrolo- and pyrazolo- pyridazinones together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said novel substituted pyrrolo- and pyrazolo- pyridazinones are binding to the prenyl binding pocket of PDEδ and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDEδ to K-Ras and of Ras signaling in cells.

  本发明涉及新型取代吡咯并吡唑吡啶酮，以及含有至少一种这些新型取代吡咯并吡唑吡啶酮的药物组合物，该药物组合物还包括至少一种药用可接受的载体、赋形剂和/或稀释剂。所述新型取代吡咯并吡唑吡啶酮结合到PDEδ的藤黄素结合口袋，因此，通过抑制PDEδ与K-Ras的结合以及细胞中Ras信号传导的结合，对癌症的预防和治疗具有用处。
• [EN] NEW COSMETIC COMPOSITIONS COMPRISING CATIONIC DYES AND PROCESS FOR DIRECT DYEING OF KERATIN FIBERS<br/>[FR] NOUVELLES COMPOSITIONS COSMÉTIQUES COMPRENANT DES COLORANTS CATIONIQUES, ET PROCÉDÉ DE COLORATION DIRECTE DE FIBRES DE KÉRATINE
  申请人：ALFA PARF GROUP S P A

  公开号：WO2014202152A1

  公开（公告）日：2014-12-24

  The present invention relates to new compositions for dyeing keratin fibers comprising, in a medium suitable for dyeing, one or more cationic dye of general formula (I) or (II), or a physiologically tolerated adduct thereof with an acid: (II), as well as to a process for dyeing keratin fibers comprising one or more cationic dye of general formula (I) or (II), or a physiologically tolerated adduct thereof with an acid.

  本发明涉及用于染色角蛋白纤维的新组合物，所述组合物包括适用于染色的介质中的一个或多个阳离子染料，其具有一般式(I)或(II)，或其与酸的生理耐受加合物：(II)，以及一种用于染色角蛋白纤维的方法，包括使用一个或多个具有一般式(I)或(II)的阳离子染料，或其与酸的生理耐受加合物。
• [EN] NEW PROCESS FOR PREPARING ARYLBORANES BY ARYLATION OF ORGANOBORON COMPOUNDS<br/>[FR] NOUVEAU PROCÉDÉ POUR LA PRÉPARATION D'ARYLBORANES PAR ARYLATION DE COMPOSÉS ORGANOBORÉS
  申请人：UNIV BORDEAUX 1

  公开号：WO2014009169A1

  公开（公告）日：2014-01-16

  The present invention relates to a new process for the preparation of an arylborane compound, by arylation of a B-H bond, which comprises a step (1) of contacting an arenediazonium salt or a heteroarenediazonium salt with an organoboron compound containing at least one B-H bond, in a reaction medium containing a solvent, in the absence of base, in the absence or in the presence of an activating agent, for the preparation of an arylborane compound, and a possible step (2) of recovery and purification of said arylborane compound obtained at the step (1), said arylborane being in particular an aminoarylborane, and a possible step (3) of refunctionalisation of said arylborane obtained at step (1) or (2) for the preparation of aryl boronic derivatives or arylborates.

  本发明涉及一种制备芳基硼烷化合物的新工艺，通过芳基硼-氢键的芳基化，包括以下步骤：(1)将芳基重氮盐或杂环芳基重氮盐与至少含有一个硼-氢键的有机硼化合物在反应介质中接触，所述反应介质包含溶剂，在无碱的情况下，在缺乏或存在活化剂的情况下，用于制备芳基硼烷化合物，并可能进行(2)步骤以回收和纯化在步骤(1)中得到的所述芳基硼烷化合物，所述芳基硼烷化合物特别是氨基芳基硼烷，以及可能进行(3)步骤对在步骤(1)或(2)中得到的所述芳基硼烷进行重官能化，用于制备芳基硼酸衍生物或芳基硼酸酯。
• [EN] SUBSTITUTED UREA EIF2α KINASE ACTIVATORS<br/>[FR] ACTIVATEURS SUBSTITUÉS DE L'URÉE-KINASE EIF2&Agr;
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2015038778A1

  公开（公告）日：2015-03-19

  This disclosure relates to substituted urea eIF2α kinase activators including methods of making and using the same. For example, such activators can include cycloalkyl aryl ureas, which activate at least one eIF2α kinase. These compounds may be useful for treatment of diseases such as, for example, cancer, hemolytic anemia not caused by infectious agents, Wolcott-Rallison syndrome, neurodegenerative disease, tuberous sclerosis complex, fragile-X syndrome, autism spectrum disorder, and ribosomal defect disease.

  本公开涉及替代脲eIF2α激酶激活剂，包括其制备和使用方法。例如，这些激活剂可以包括环烷基芳基脲，其激活至少一种eIF2α激酶。这些化合物可能对治疗疾病有用，例如癌症、非感染性溶血性贫血、沃尔科特-拉里森综合征、神经退行性疾病、结节性硬化症、脆性X综合征、自闭症谱系障碍和核糖体缺陷疾病。
• SELECTIVE PLACEMENT OF CARBON NANOTUBES THROUGH FUNCTIONALIZATION
  申请人：Afzali-Ardakani Alina

  公开号：US20100145034A1

  公开（公告）日：2010-06-10

  The present invention provides a method for selectively placing carbon nanotubes on a substrate surface by using functionalized carbon nanotubes having an organic compound that is covalently bonded to such carbon nanotubes. The organic compound comprises at least two functional groups, the first of which is capable of forming covalent bonds with carbon nanotubes, and the second of which is capable of selectively bonding metal oxides. Such functionalized carbon nanotubes are contacted with a substrate surface that has at least one portion containing a metal oxide. The second functional group of the organic compound selectively bonds to the metal oxide, so as to selectively place the functionalized carbon nanotubes on the at least one portion of the substrate surface that comprises the metal oxide.

  本发明提供了一种通过使用具有与碳纳米管共价键合的有机化合物的功能化碳纳米管，从而在基底表面上选择性地放置碳纳米管的方法。该有机化合物包括至少两个功能基团，第一个功能基团能够与碳纳米管形成共价键，第二个功能基团能够选择性地与金属氧化物结合。这种功能化碳纳米管与至少一部分含有金属氧化物的基底表面接触。有机化合物的第二功能基团选择性地与金属氧化物结合，从而将功能化碳纳米管选择性地放置在包含金属氧化物的基底表面的至少一部分上。