Methyl 2-amino-3-chlorobutanoate | 100606-82-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-amino-3-chlorobutanoate
• CAS: 100606-82-4
• 化学式: C₅H₁₀ClNO₂
• 分子量: 151.59
• InChiKey: RLSIAHTWMIICMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Processes for producing B-halogeno-a-amino-carboxylic acids and phenylcysteine derivatives and intermediates thereof
  申请人：——

  公开号：US20020082450A1

  公开（公告）日：2002-06-27

  An industrially advantageous method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids is provided. Methods are also provided of producing optically active N-protected-S-phenylcysteines having high optical purity and of intermediates thereof, respectively, in which the above production method is utilized. A method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids or salts thereof is disclosed which comprises halogenating the hydroxyl group of a &bgr;-hydroxy-&agr;-aminocarboxylic acid (in which the basicity of the amino group in &agr;-position is not masked by the presence of a substituent on said amino group) or a salt thereof with an acid with a halogenating agent. A method of producing optically active N-protected-S-phenylcysteines represented by the general formula (3) or salts thereof is further disclosed which comprises applying the above production method to optically active serine or a salt thereof and then carrying out treatment with an amino-protecting agent and reaction with thiophenol under a basic condition. 1

  提供了一种工业上有利的制备&bgr;-卤代-&agr;-氨基羧酸的方法。还提供了制备高光学纯度N-保护-S-苯基半胱氨酸及其中间体的方法，其中利用上述生产方法。揭示了一种制备&bgr;-卤代-&agr;-氨基羧酸或其盐的方法，其包括使用酸和卤代试剂卤代&bgr;-羟基-&agr;-氨基羧酸（其中&agr;-位置的氨基基性未被氨基上的取代基掩盖）或其盐的羟基。还揭示了一种制备由通式（3）表示的光学活性N-保护-S-苯基半胱氨酸或其盐的方法，其包括将上述生产方法应用于光学活性丝氨酸或其盐，并在碱性条件下进行氨基保护剂的处理和与硫苯酚反应。
• PROCESSES FOR PRODUCING BETA-HALOGENO-ALPHA-AMINO-CARBOXYLIC ACIDS AND PHENYLCYSTEINE DERIVATIVES AND INTERMEDIATES THEREOF
  申请人：KANEKA CORPORATION

  公开号：EP1046634A1

  公开（公告）日：2000-10-25

  An industrially advantageous method of producing β-halogeno-α-aminocarboxylic acids is provided. Methods are also provided of producing optically active N-protected-S-phenylcysteines having high optical purity and of intermediates thereof, respectively, in which the above production method is utilized. A method of producing β-halogeno-α-aminocarboxylic acids or salts thereof is disclosed which comprises halogenating the hydroxyl group of a β-hydroxy-α-aminocarboxylic acid (in which the basicity of the amino group in α-position is not masked by the presence of a substituent on said amino group) or a salt thereof with an acid with a halogenating agent. A method of producing optically active N-protected-S-phenylcysteines represented by the general formula (3) or salts thereof is further disclosed which comprises applying the above production method to optically active serine or a salt thereof and then carrying out treatment with an amino-protecting agent and reaction with thiophenol under a basic condition.

  本发明提供了一种具有工业优势的生产 β-卤代-α-氨基羧酸的方法。此外，还提供了利用上述生产方法分别生产具有高光学纯度的光学活性 N-保护-S-苯基半胱氨酸及其中间体的方法。 本发明公开了一种生产 β-卤代-α-氨基羧酸或其盐的方法，该方法包括将 β-羟基-α-氨基羧酸（其中 α 位氨基的碱性不因所述氨基上取代基的存在而被掩盖）的羟基或其盐与含有卤化剂的酸进行卤化。进一步公开了一种生产通式（3）代表的光学活性 N-保护-S-苯基半胱氨酸或其盐的方法，该方法包括将上述生产方法应用于光学活性丝氨酸或其盐，然后用氨基保护剂进行处理，并在碱性条件下与噻吩酚反应。
• US6372941B1
  申请人：——

  公开号：US6372941B1

  公开（公告）日：2002-04-16