1,1'-(4,6-dihydroxy-1,3-phenylene)dibutan-1-one | 75175-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 1,1'-(4,6-dihydroxy-1,3-phenylene)dibutan-1-one
• 英文别名: 1,3-bis(butanoyloxy)benzene；1,3-bis-butyryloxy-benzene；Di-O-butyryl-resorcin；m-Phenylen-dibutyrat；1,3-Bis-butyryloxy-benzol；1.3-Dibutyryloxy-benzol；(3-Butanoyloxyphenyl) butanoate
• CAS: 75175-06-3
• 化学式: C₁₄H₁₈O₄
• 分子量: 250.295
• InChiKey: CBTMYQCCEPPKSX-UHFFFAOYSA-N

物化性质

• 沸点：
  341.6±15.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,1'-(4,6-dihydroxy-1,3-phenylene)dibutan-1-one 在 zinc(II) chloride 作用下， 生成 2,4-Dihydroxy-5-butyryl-butyrophenon
  参考文献：
  名称：

  Klarmann, Journal of the American Chemical Society, 1926, vol. 48, p. 2366

  摘要：

  DOI：
• 作为产物：
  描述：

  丁酰氯 、 间苯二酚 在 盐酸 、 2-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 1,1'-(4,6-dihydroxy-1,3-phenylene)dibutan-1-one
  参考文献：
  名称：

  DERIVATIVE OF NOVEL POLYHYDROXY AROMATIC COMPOUND AND USE THEREOF

  摘要：

  提供一个具有优异美白效果的皮肤美白组合物，具体为公式I所表示的衍生物或多元醇环化合物或其药理上可接受的盐，其中 所述的芳香族环化合物，C n ，C n+1 和C n+2 是存在于芳香族环化合物中的三个相邻的碳原子，其中n是正整数，R 1 和R 2 分别是具有3至12个碳原子的饱和或不饱和直链或支链烷基或酰基，而R 3 ，R 4 ，R 5 和R 6 各自独立地选自氢、烷基、烷氧基、酰氧基、酰氧甲基、氧代、羟基、乙烯基、腈、羧醛、碳腈和醛中至少一个取代基。

  公开号：

  US20150283051A1

文献信息

• DERIVATIVE OF NOVEL POLYHYDROXY AROMATIC COMPOUND AND USE THEREOF
  申请人：RNS CO.,LTD.

  公开号：US20150283051A1

  公开（公告）日：2015-10-08

  Provided is a skin whitening composition with excellent whitening effects, specifically, a derivative or a polyhydroxy cyclic compound represented by Formula I or a pharmacologically acceptable salt thereof, comprising; wherein is derived from an aromatic cyclic compound, C n , C n+1 and C n+2 are three neighboring carbon atoms present in the aromatic cyclic compound, wherein n is a positive integer, R 1 and R 2 are each a saturated or unsaturated straight or branched alkyl or acyl group having 3 to 12 carbon atoms, and R 3 , R 4 , R 5 and R 6 are each independently at least one substituent selected from hydrogen, alkyl, alkoxy, acyloxy, acyloxymethyl, oxo, hydroxy, vinyl, nitrile, carboxaldehyde, carbonitrile and aldehyde.

  提供一个具有优异美白效果的皮肤美白组合物，具体为公式I所表示的衍生物或多元醇环化合物或其药理上可接受的盐，其中 所述的芳香族环化合物，C n ，C n+1 和C n+2 是存在于芳香族环化合物中的三个相邻的碳原子，其中n是正整数，R 1 和R 2 分别是具有3至12个碳原子的饱和或不饱和直链或支链烷基或酰基，而R 3 ，R 4 ，R 5 和R 6 各自独立地选自氢、烷基、烷氧基、酰氧基、酰氧甲基、氧代、羟基、乙烯基、腈、羧醛、碳腈和醛中至少一个取代基。
• Ytterbium triflate catalysed Friedel–Crafts reaction using carboxylic acids as acylating reagents under solvent-free conditions
  作者：Can Jin、Jie Li、Weike Su

  DOI：10.3184/030823409x12511347683523

  日期：2009.10

  The Friedel–Crafts acylation of 1-naphthol and phenol derivatives with carboxylic acids were investigated by using a catalytic amount of metal-triflate, in particular Yb(OTf)3, under solvent-free conditions. Both aliphatic and aromatic carboxylic acids reacted easily to afford the corresponding hydroxyaryl ketones.

  在无溶剂条件下，通过使用催化量的金属三氟甲磺酸盐，特别是 Yb(OTf)3，研究了 1-萘酚和苯酚衍生物与羧酸的 Friedel-Crafts 酰化反应。脂肪族和芳香族羧酸都容易反应得到相应的羟基芳基酮。
• Desai; Mavani, Proceedings - Indian Academy of Sciences, Section A, 1949, vol. <A> 29, p. 269,270
  作者：Desai、Mavani

  DOI：——

  日期：——
• Zur Kenntnis der Resorzinketone und C-Alkylresorzine
  作者：K. W. Rosenmund、R. Buchwald、Th. Deligiannis

  DOI：10.1002/ardp.19332710606

  日期：——
• CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF
  申请人：Anderson Daniel Griffith

  公开号：US20080145338A1

  公开（公告）日：2008-06-19

  Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.