N-(morpholin-4-ylmethyl)thiourea | 24905-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-(morpholin-4-ylmethyl)thiourea
• 英文别名: [(morpholino)methyl]thiourea；1-morpholinomethyl-thiourea；N-morpholinomethylthiourea；morpholino methyl thiourea；morpholinomethyl thiourea；morpholinomethylthiourea；Thiourea, (4-morpholinylmethyl)-；morpholin-4-ylmethylthiourea
• CAS: 24905-91-7
• 化学式: C₆H₁₃N₃OS
• 分子量: 175.255
• InChiKey: WNVUHGQWKOFCPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  82.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(morpholin-4-ylmethyl)thiourea 、 copper(II) nitrate 以 乙醇 为溶剂， 生成 Cu(NO3)2*morpholino methyl thiourea
  参考文献：
  名称：

  Sabastiyan, A.; Venkappayya, D., Journal of the Indian Chemical Society, 1984, vol. 61, p. 16 - 19

  摘要：

  DOI：
• 作为产物：
  描述：

  硫脲 、 alkaline earth salt of/the/ methylsulfuric acid 在 水 作用下， 生成 N-(morpholin-4-ylmethyl)thiourea
  参考文献：
  名称：

  Morpholinomethyl Derivatives of Urea and Substituted Ureas¹

  摘要：

  DOI：

  10.1021/ja01230a019

文献信息

• Synthesis and characterization of peroxo complexes of uranium(VI) with some Mannich base ligands
  作者：Balgar Singh、Simpy Mahajan、Haq N. Sheikh、Mohita Sharma、Bansi L. Kalsotra

  DOI：10.1007/s00706-011-0587-2

  日期：2012.1

  AbstractUranium(VI) peroxo complexes of composition [UO(O2)L–L(NO3)2], where L–L are the Mannich base ligands morpholinobenzyl urea, piperidinobenzyl urea, morpholinobenzyl thiourea, piperidinobenzyl thiourea, morpholinomethyl thiourea, piperidinomethyl thiourea, or morpholinomethyl urea, are reported. The synthesized complexes were characterized by use of a variety of physicochemical techniques, viz

  摘要组成为[UO（O 2）L–L（NO 3）2 ]的铀（VI）过氧配合物，其中L–L为曼尼希碱配体吗啉代苄基尿素，哌啶子基苄基脲，吗啉代苄基硫脲，哌啶子基苄基硫脲，吗啉代甲基硫脲，哌啶子基甲基硫脲报道了吗啉代甲基脲。通过使用多种物理化学技术来表征合成的复合物。元素分析，摩尔电导率，磁化率测量，红外，电子，质量，1 H NMR和13C NMR光谱和TGA / DTA研究。这些研究表明，该配合物本质上既是非电解的又是抗磁性的。配体通过羰基氧或硫代羰基硫和环氮以二齿模式与金属结合。质谱证实了配合物的分子量。该复合物的抗真菌活性大于相应的游离配体的抗真菌活性。 图形概要
• Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines
  作者：Yu. A. Martinovich、S. M. Ramsh、F. Hamoud、V. S. Fundamenskii、V. V. Gurzhii、V. I. Zakharov、E. S. Khrabrova

  DOI：10.1134/s107042801806009x

  日期：2018.6

  Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N-(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N,N′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea with piperidine and formaldehyde, only symmetrical N,N′-bis(piperidin-1-ylmethyl)thiourea was isolated, regardless

  硫脲与等摩尔量的甲醛和吗啉进行三组分缩合可得到N-（吗啉-4-基甲基）衍生物，而与2当量的甲醛和胺进行类似反应可得到对称的N，N'-双（吗啉-4-基甲基）硫脲。在硫脲与哌啶和甲醛的缩合中，无论反应物的比例如何，仅分离出对称的N，N′-双（哌啶-1-基甲基）硫脲。
• Anand, Sarika, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 2007, vol. 46, # 3, p. 401 - 406
  作者：Anand, Sarika

  DOI：——

  日期：——
• Synthesis and characterization of cyano complexes of oxotungsten(IV) with morpholinomethyl urea and related ligands
  作者：M. S. Pathania、H. N. Sheikh、B. L. Kalsotra

  DOI：10.1134/s0036023606090075

  日期：2006.9

  The synthesis and characterization of complexes, (Ph3P)(2)NH2[WO(CN)(3)L-L] center dot 3H(2)O and Cs[WO(CN)(3)L-L] center dot H2O (where L-L = morpholinomethylurea, morpholinomethylthiourea, piperidinomethylurea, piperidinomethylthiourea, pyrrolidinomethylurea, and pyrrolidinomethythiourea) are presented. The complexes have been prepared by the reaction of K3Na[WO2(CN)(4)] center dot 6H(2)O with morpholinomethylurea and related ligands in aqueous solution around a pH of 7. These have been isolated as bis(triphenylphospine)imminium or cesium salts. The complexes have been characterized by elemental analysis, IR, UV-Vis spectra, magnetic susceptibility and conductivity measurements in addition to TGA/DTA.
• Synthesis and characterization of some oxodiperoxo molybdenum(VI) complexes of Morpholinomethyl urea and related ligands
  作者：H. N. Sheikh、A. Hussain、B. L. Kalsotra

  DOI：10.1134/s003602360605007x

  日期：2006.5

  The oxodiperoxo complexes of Mo(VI) of the type [MoO(O-2)(2)L], where L = Morpholinomethyl urea, morpholinomethyl thiourea, piperidinomethyl urea, piperidinomethyl thiourea, pyrrolidinomethyl urea, and pyrrolidinomethyl thiourea have been synthesized and characterized by elemental analysis, molar conductance, IR, UV-Vis, and TGA/DTA techniques. It is shown that the ligands coordinate to the metal ion in a symmetrical bidentate fashion through heterocyclic nitrogen and carbonyl oxygen or thiocarbonyl sulfur. Thermal studies indicate continuous weight loss until a stable oxide is formed.