2-羟基苯基三氟甲基砜 | 32858-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基苯基三氟甲基砜
• 英文名称: 2-Hydroxyphenyltrifluoromethylsulphone
• 英文别名: 2-((trifluoromethyl)sulfonyl)phenol；o-Hydroxyphenyl-trifluormethylsulfon；2-Trifluoromethanesulfonylphenol；2-(trifluoromethylsulfonyl)phenol
• CAS: 32858-96-1
• 化学式: C₇H₅F₃O₃S
• mdl: MFCD16547647
• 分子量: 226.176
• InChiKey: XQJFFCCRZYJAKT-UHFFFAOYSA-N

物化性质

• 沸点：
  293.9±40.0 °C(Predicted)
• 密度：
  1.548±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-氯-2-碘苯 在 chromium(VI) oxide 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 2-羟基苯基三氟甲基砜
  参考文献：
  名称：

  芳基三氟甲基砜的制备和氟化

  摘要：

  由相应的芳基卤化物合成了一系列的氯苯基和硝基苯基三氟甲基硫化物和砜[1]。已经研究了四正丁基氟化铵和氟化钾对这些化合物的氟化。我们的结果表明，与氟化脱氯相比，它们通常更容易受到氟代脱硝作用的影响。

  DOI：

  10.1016/s0022-1139(00)80343-7

文献信息

• AMIDE COMPOUND AND USE OF SAME FOR NOXIOUS ARTHROPOD CONTROL
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20170295789A1

  公开（公告）日：2017-10-19

  There is provided a noxious arthropod controlling agent containing an amide compound of formula (I): wherein R 1 represents a C1-C8 chain hydrocarbon group optionally having one or more groups selected from Group A, R 2 represents a hydrogen atom or the like, R 3 represents a hydrogen atom or the like, R 5 and R 6 are the same or different, and independently represent a hydrogen atom or the like, Y represents an oxygen atom or the like, m represents 0, 1, 2, 3, 4, 5, 6 or 7, and Q represents a C1-C8 chain hydrocarbon group optionally having one or more atoms or groups selected from Group D.

  提供了一种含有化合物的有害节肢动物控制剂（I）的公式：其中R1代表一个C1-C8链烃基，可选地具有来自A组的一个或多个基团，R2代表氢原子或类似物，R3代表氢原子或类似物，R5和R6相同或不同，独立地代表氢原子或类似物，Y代表氧原子或类似物，m代表0、1、2、3、4、5、6或7，Q代表一个C1-C8链烃基，可选地具有来自D组的一个或多个原子或基团。
• Ortho-lithiation reaction of aryl triflones
  作者：Yuji Sumii、Misaki Taniguchi、Xiu-Hua Xu、Etsuko Tokunaga、Norio Shibata

  DOI：10.1016/j.tet.2018.07.055

  日期：2018.9

  ortho-lithiation of aryl triflones. We found that the trifluoromethyl sulfonyl group is not only an important structural motif in biologically active molecules and specialty materials, but also an excellent DMG moiety for ortho-metalation reactions. The use of a base that causes steric hindrance, LTMP, is the key for successful transformation to furnish a variety of ortho-substituted aryl triflones in good yields

  取代的芳烃的邻位锂化是合成邻位取代的芳烃的有效方法。尽管已经报道了各种各样的定向金属化基团（DMG），但从未使用过三氟甲基砜。我们公开了芳基三氟硅氧烷的邻位锂化的第一个例子。我们发现三氟甲基磺酰基不仅是生物活性分子和特种材料中的重要结构基序，而且是邻位金属化反应的优良DMG部分。使用导致空间位阻的碱LTMP是成功转化以提供各种邻苯二甲酸盐的关键取代的芳基三氟甲磺酸酯收率好。通过金属催化的偶联反应证明了所得的邻位取代的芳基三氟甲磺酸酯的进一步官能化。
• METHOD FOR PRODUCING PHENOLIC COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20170137377A1

  公开（公告）日：2017-05-18

  Provided is a method for producing a compound represented by formula (2-b), which is useful as an intermediate for producing agricultural chemicals. The method includes a step for obtaining a compound represented by formula (2-a) by oxidizing the compound represented by formula (1) with hydrogen peroxide in the presence of sulfuric acid and/or a C 1-6 alkanesulfonic acid that may be halogen-substituted and in the presence of a C 2-12 aliphatic carboxylic acid and/or sulfolane. The method also includes a step for obtaining a compound represented by formula (2-b) by nitrating a compound represented by formula (2-a) in the presence of sulfuric acid and/or a C 1-6 alkanesulfonic acid that may be halogen-substituted.

  提供了一种生产化合物的方法，该化合物由公式（2-b）表示，可用作生产农业化学品的中间体。该方法包括以下步骤：在硫酸和/或C1-6烷基磺酸（可能被卤素取代）和C2-12脂肪族羧酸和/或磺酰乙烷的存在下，通过过氧化氢氧化公式（1）表示的化合物以获得公式（2-a）表示的化合物；并在硫酸和/或C1-6烷基磺酸（可能被卤素取代）的存在下通过硝化公式（2-a）表示的化合物以获得公式（2-b）表示的化合物。
• METHOD FOR CONTROLLING ARTHROPOD PEST
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150344466A1

  公开（公告）日：2015-12-03

  An amide compound represented by formula (I): [wherein A represents a 3- to 7-membered saturated heterocyclic ring which contains, as ring-forming component(s), one or more atoms or groups selected from the group consisting of an oxygen atom and —S(O) t —, t represents 0, etc., R 1 and R 2 are the same or different and represent a hydrogen atom, etc., n represents 0, etc., the following formula (II): represents a 5-membered aromatic ring, in which Z represents a nitrogen atom or a carbon atom and X 1 , X 2 and X 3 are the same or different and represent a nitrogen atom, etc., R 3 and R 4 are the same or different and represent a hydrogen atom, etc., m represents 0 to 2, Q represents one group selected from group A or a C1 to C8 chain hydrocarbon group optionally having one group selected from group A, Y represents an oxygen atom, etc., u represents 0, etc., and v represents 0, etc.] has excellent arthropod pest controlling effects.

  化合物式(I)所代表的酰胺化合物：[其中A代表一个3到7个成员的饱和杂环环，该环包含作为环构成组分之一或多个原子或基团，所选自氧原子和—S（O）t—群，t代表0等；R1和R2相同或不同，代表氢原子等；n代表0等；下列式子(II)代表一个5个成员的芳香环，在该环中Z代表一个氮原子或一个碳原子，X1、X2和X3相同或不同，代表氮原子等，R3和R4相同或不同，代表氢原子等，m代表0到2，Q代表从群A中选择的一个群或一个C1到C8链烃基团，该基团可以选择从群A中选择的一个群，Y代表氧原子等，u代表0等，v代表0等]具有优良的节肢动物害虫控制效果。
• Preparation process of fluorine subsituted aromatic compound
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1013629A1

  公开（公告）日：2000-06-28

  A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylaminodifluoromethane compound, for example, 2,2'-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.

  本发明公开了一种氟取代芳香族化合物的制备工艺，该工艺包括使具有羟基的芳香族化合物的碱金属盐或碱土金属盐与有机氟化剂反应。作为氟化剂的代表，举例说明了一种双二烷基氨基二氟甲烷化合物，例如 2,2'-二氟-1,3-二甲基咪唑烷。 根据该工艺，工业上有用的氟化芳烃化合物，例如氟苯、氟取代的二苯甲酮、氟取代的二元砜，无需特定设备即可轻松制备，经济实惠。