3-(pyridin-4-yl)isoquinolin-1-(2H)-one | 476493-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(pyridin-4-yl)isoquinolin-1-(2H)-one
• 英文别名: 3-(4-pyridyl)-2H-isoquinolin-1-one；3-pyridin-4-yl-2H-isoquinolin-1-one
• CAS: 476493-24-0
• 化学式: C₁₄H₁₀N₂O
• 分子量: 222.246
• InChiKey: SLYMYPWIPMNAAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(pyridin-4-yl)isoquinolin-1-(2H)-one 在 盐酸 、 三氯氧磷 作用下， 以 1,4-二氧六环 、 二甲基亚砜 为溶剂， 反应 99.5h， 生成 N-(3-fluorophenyl)-3-pyridin-4-ylisoquinolin-1-amine
  参考文献：
  名称：

  WO2020142748A5

  摘要：

  公开号：

  WO2020142748A5
• 作为产物：
  描述：

  4-乙酰吡啶 、 2-碘苯甲酰胺 在 potassium tert-butylate 作用下， 以 二甲基亚砜 为溶剂， 反应 3.0h， 以72%的产率得到3-(pyridin-4-yl)isoquinolin-1-(2H)-one
  参考文献：
  名称：

  在 DMSO 中通过 SRN1 反应一锅法合成 3-取代异喹啉-1-(2H)-ones 和融合异喹啉-1-(2H)-ones

  摘要：

  3-取代的异喹啉-1-(2H)-酮和稠合的异喹啉-1-(2H)-酮是通过 2-碘苯甲酰胺与芳香族（苯乙酮，1-（苯并[d]）的烯醇化物的光刺激 SRN1 反应获得的[1,3]dioxol-5-yl)ethanone, 1- and 2-naphthylmethyl ketones, and 2-, 3-, and 4-acetylpyridine), 脂肪族（1-adamantylmethyl ketone）和环酮（1-和 2-茚满酮、α-和β-四氢萘酮以及 1-苯并芴酮）在 DMSO 中。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

  DOI：

  10.1002/ejoc.200600244

文献信息

• FUSED HETEROCYCLIC COMPOUND AND MEDICINAL USE THEREOF
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1396488A1

  公开（公告）日：2004-03-10

  The fused heterocyclic compound of the present invention, which is represented by the formula (I): wherein each symbol is as defined in the specification, an optically active form thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a water adduct thereof show poly(ADP-ribose) synthase inhibitory action and are useful as therapeutic drugs for cerebral infarction.

  本发明的融合杂环化合物，其化学式表示为（I）：其中每个符号如规范中定义，其光学活性形式，其药学上可接受的盐，其水合物和水加合物显示聚(ADP-核糖)合酶抑制作用，并可用作治疗脑梗死的药物。
• [EN] HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HEPATITE C
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2005046712A1

  公开（公告）日：2005-05-26

  Compounds are disclosed having general formula (I), wherein R1, R2, R3, R4, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

  揭示了具有一般式(I)的化合物，其中R1、R2、R3、R4、R'、B、Y和X在描述中有所描述。还揭示了包含这些化合物的组合物以及使用这些化合物来抑制HCV的方法。
• HEPATITIS C VIRUS INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1687018B1

  公开（公告）日：2012-01-25
• [EN] METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS<br/>[FR] PROCÉDÉS ET MATÉRIAUX POUR AUGMENTER LES NIVEAUX DE POLYPEPTIDES EB DE FACTEUR DE TRANSCRIPTION
  申请人：UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION

  公开号：WO2020142748A1

  公开（公告）日：2020-07-09

  This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided.
• One-Pot Synthesis of 3-Substituted Isoquinolin-1-(2H)-ones and Fused Isoquinolin-1-(2H)-ones by SRN1 Reactions in DMSO
  作者：Javier F. Guastavino、Silvia M. Barolo、Roberto A. Rossi

  DOI：10.1002/ejoc.200600244

  日期：2006.9

  3-Substituted isoquinolin-1-(2H)-ones and fused isoquinolin-1-(2H)-ones have been obtained by the photostimulated SRN1 reactions of 2-iodobenzamide with the enolates of aromatic (acetophenone, 1-(benzo[d][1,3]dioxol-5-yl)ethanone, 1- and 2-naphthyl methyl ketones, and 2-, 3-, and 4-acetylpyridine), aliphatic (1-adamantyl methyl ketone), and cyclic ketones (1- and 2-indanone, α- and β-tetralone, and

  3-取代的异喹啉-1-(2H)-酮和稠合的异喹啉-1-(2H)-酮是通过 2-碘苯甲酰胺与芳香族（苯乙酮，1-（苯并[d]）的烯醇化物的光刺激 SRN1 反应获得的[1,3]dioxol-5-yl)ethanone, 1- and 2-naphthylmethyl ketones, and 2-, 3-, and 4-acetylpyridine), 脂肪族（1-adamantylmethyl ketone）和环酮（1-和 2-茚满酮、α-和β-四氢萘酮以及 1-苯并芴酮）在 DMSO 中。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)